1-methyl-4-hydroxy-1,2,3,4-tetrahydroquinoline | 24206-53-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-methyl-4-hydroxy-1,2,3,4-tetrahydroquinoline
• 英文别名: 1-methyl-1,2,3,4-tetrahydro-quinolin-4-ol；4-Hydroxy-1-methyl-1,2,3,4-tetrahydrochinolin；1,2,3,4-tetrahydro-1-methyl-4-Quinolinol；1-methyl-3,4-dihydro-2H-quinolin-4-ol
• CAS: 24206-53-9
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: PKNUKFLDADDHEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙酸乙烯酯 、 N-methoxymethyl-N-methylaniline 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以69%的产率得到1-methyl-4-hydroxy-1,2,3,4-tetrahydroquinoline
  参考文献：
  名称：

  Electroorganic chemistry. 62. Reaction of iminium ion with nucleophile: a versatile synthesis of tetrahydroquinolines and julolidines

  摘要：

  DOI：

  10.1021/ja00385a033

文献信息

• DERMATITIS TREATING AGENT (AS AMENDED)
  申请人：Naotsuka Atsuko

  公开号：US20100130494A1

  公开（公告）日：2010-05-27

  The present invention is to provide a topical dermatitis treating agent which comprises a pyridine compound represented by the following formula [I]: wherein R 1 and R 2 each represent a lower alkoxy group, ═X— represents a group represented by the formula: or a group represented by the formula: ═N—, Ring A represents a saturated or unsaturated bicyclic nitrogen-containing heterocyclic group having 1 to 4 substituents selected from hydroxyl group, oxo group, a lower alkoxy group, a di-lower alkylaminophenyl group, a pyperidino-lower alkoxy group, a morpholino-lower alkoxy group, a cyclo-lower alkylamino-lower alkylamino group, pyridyl group and morpholino group, and represents a single bond or a double bond, or a pharmaceutically acceptable salt thereof as an active ingredient.

  本发明提供了一种局部治疗皮炎的药剂，其包含下式[I]所表示的吡啶化合物：其中R1和R2各代表低烷氧基，═X—代表由以下式表示的基团：或由以下式表示的基团：═N—，环A代表具有1至4个取代基（所选的是羟基、氧代基、低烷氧基、二低烷基氨基苯基、吡啶基低烷氧基、吗啉基低烷氧基、环状低烷基氨基-低烷基氨基基、吡啶基和吗啉基）的饱和或不饱和双环氮杂环基，且表示单键或双键，或其药学上可接受的盐作为活性成分。
• DERMATITIS REMEDIES
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1941881A1

  公开（公告）日：2008-07-09

  The present invention is to provide a topical dermatitis treating agent which comprises a pyridine compound represented by the following formula [I]: wherein R1 and R2 each represent a lower alkoxy group, =X- represents a group represented by the formula: or a group represented by the formula: =N-, Ring A represents a saturated or unsaturated bicyclic nitrogen-containing heterocyclic group having 1 to 4 substituents selected from hydroxyl group, oxo group, a lower alkoxy group, a di-lower alkylaminophenyl group, a pyperidino-lower alkoxy group, a morpholino-lower alkoxy group, a cyclo-lower alkylamino-lower alkylamino group, pyridyl group and morpholino group, and ---- represents a single bond or a double bond, or a pharmaceutically acceptable salt thereof as an active ingredient.

  本发明旨在提供一种局部皮炎治疗剂，它由下式[I]代表的吡啶化合物组成： 其中R1和R2各自代表低级烷氧基，=X-代表由式[I]代表的基团： 环 A 代表具有 1 至 4 个取代基的饱和或不饱和双环含氮杂环基团，取代基可选 自羟基、氧代基团、低级烷氧基、二低级烷基氨基苯基、吡咯烷基低级烷氧基、吗啉基 低级烷氧基、环低级烷基氨基低级烷基氨基、吡啶基和吗啉基，---- 代表单键或双键、 或其药学上可接受的盐作为活性成分。
• Naphthalene derivatives for the treatment of dermatitis and psoriasis
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP1941881B1

  公开（公告）日：2014-08-13
• USE OF A PYRIDINE COMPOUND FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF SKIN LESIONS
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP1804797B1

  公开（公告）日：2012-04-25
• EP2727594A1
  申请人：——

  公开号：EP2727594A1

  公开（公告）日：2014-05-07