3-(2-methoxyphenyl)-5-(p-tolyl)-1,2,4-oxadiazole | 1443017-23-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(2-methoxyphenyl)-5-(p-tolyl)-1,2,4-oxadiazole
• 英文别名: 3-(2-Methoxyphenyl)-5-(4-methylphenyl)-1,2,4-oxadiazole；3-(2-methoxyphenyl)-5-(4-methylphenyl)-1,2,4-oxadiazole
• CAS: 1443017-23-9
• 化学式: C₁₆H₁₄N₂O₂
• 分子量: 266.299
• InChiKey: AUVBNUUJXWFOMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  48.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲基苯甲酰基丁酯 、 N-羟基-2-甲氧基-苯甲酰胺 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以77%的产率得到3-(2-methoxyphenyl)-5-(p-tolyl)-1,2,4-oxadiazole
  参考文献：
  名称：

  Microwave assisted synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from substituted amidoximes and benzoyl cyanides

  摘要：

  We report herein the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from amidoximes and substituted or unsubstituted benzoyl cyanides under microwave irradiation. Substituted or unsubstituted O-carboxyphenyl amidoxime is a key intermediate of this alternative method developed for the synthesis of these heterocycles. These reactions employ simple synthetic protocols devoid of lengthy purification procedures and proceed with good yield. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.101

文献信息

• Microwave assisted synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from substituted amidoximes and benzoyl cyanides
  作者：Shivaji Kandre、Pundlik Rambhau Bhagat、Rajiv Sharma、Amol Gupte

  DOI：10.1016/j.tetlet.2013.04.101

  日期：2013.7

  We report herein the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from amidoximes and substituted or unsubstituted benzoyl cyanides under microwave irradiation. Substituted or unsubstituted O-carboxyphenyl amidoxime is a key intermediate of this alternative method developed for the synthesis of these heterocycles. These reactions employ simple synthetic protocols devoid of lengthy purification procedures and proceed with good yield. (c) 2013 Elsevier Ltd. All rights reserved.