3,3-dimethyl-undecan-4-one | 92169-04-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,3-dimethyl-undecan-4-one
• 英文别名: 3,3-Dimethylundecan-4-one
• CAS: 92169-04-5
• 化学式: C₁₃H₂₆O
• 分子量: 198.349
• InChiKey: GTMJUMJXIYWBOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氯代-2-甲基丁烷 、 辛酸乙酯 生成 3,3-dimethyl-undecan-4-one
  参考文献：
  名称：

  Petrov,A.D. et al., Bulletin de la Societe Chimique de France, 1961, p. 1593 - 1595

  摘要：

  DOI：

文献信息

• Water-Soluble CC-1065 Analogs and Their Conjugates
  申请人：Beusker Patrick Henry

  公开号：US20090318668A1

  公开（公告）日：2009-12-24

  This invention relates to novel analogs of the DNA-binding alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

  这项发明涉及DNA结合烷基化剂CC-1065的新型类似物及其结合物。此外，该发明涉及用于制备上述剂和它们的结合物的中间体。这些结合物设计为在一个或多个激活步骤之后以及/或由结合物控制的速率和时间跨度下释放它们的（多种）荷载，以便选择性地传递和/或可控地释放一个或多个所述的DNA烷基化剂。这些剂、结合物和中间体可用于治疗以不良（细胞）增殖为特征的疾病。例如，这项发明的剂和结合物可用于治疗肿瘤。
• Salt effects on the reactivity and the stability of organomanganese reagents
  作者：Gérard Cahiez、Lynah Razafintsalama、Blandine Laboue、Francois Chau

  DOI：10.1016/s0040-4039(97)10747-x

  日期：1998.2

  The reactivity and the stability of organomanganese reagents prepared from the ate complexes MnX2 . 2LiBr (X = Br,I) and MnCl2 . R4NX (X = Br, Cl) were studied. The preparation and the use for synthetic applications of stable sec-and tert-alkylmanganese bromides in ether as well as the acylation of RMnCl by R'COOCOOEt in THF were successfully achieved for the first time. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Petrov,A.D. et al., Journal of general chemistry of the USSR, 1962, vol. 32, p. 691 - 696
  作者：Petrov,A.D. et al.

  DOI：——

  日期：——
• Petrov,A.D. et al., Bulletin de la Societe Chimique de France, 1961, p. 1593 - 1595
  作者：Petrov,A.D. et al.

  DOI：——

  日期：——