3-(3,4-dimethylphenylamino)-1-phenylpropan-1-one | 63352-76-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(3,4-dimethylphenylamino)-1-phenylpropan-1-one
• 英文别名: 3-[(3,4-Dimethylphenyl)amino]-1-phenylpropan-1-one；3-(3,4-dimethylanilino)-1-phenylpropan-1-one
• CAS: 63352-76-1
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: ULHOFTJEICTJFE-UHFFFAOYSA-N

物化性质

• 沸点：
  433.5±33.0 °C(Predicted)
• 密度：
  1.083±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(3,4-dimethylphenylamino)-1-phenylpropan-1-one 以14%的产率得到
  参考文献：
  名称：

  DENIS G. I.; GURYAVICHENE YU. V.; CHEKUOLENE L. V.; STYAPONAVICHYUS YU. Y+, LIETTSR MOKSLU AKAD. DARVAI, TR. AN LITSSR, 1977, B, HO 1 (98), 33-38

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4-二甲基苯胺 、 1-苯基-2-丙烯基-1-酮 在 sodium carbonate 作用下， 以 水 为溶剂， 反应 0.5h， 以94%的产率得到3-(3,4-dimethylphenylamino)-1-phenylpropan-1-one
  参考文献：
  名称：

  Aza-Michael reaction promoted by aqueous sodium carbonate solution

  摘要：

  A general and efficient aza-Michael reaction promoted by aqueous sodium carbonate solution has been developed. The reaction has complete mono-alkylation selectivity and proceeds with complete chirality retention for chiral amino esters. With a broad substrate scope, a well-common catalyst and simple operation, the catalytic approach provides a facile, practicable, economical, and environmentally benign method for the synthesis of beta-amino carbonyl compounds. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.03.043

文献信息

• Aza-Michael reaction promoted by aqueous sodium carbonate solution
  作者：Xiao-Ji Tang、Zhao-Lei Yan、Wen-Liang Chen、Ya-Ru Gao、Shuai Mao、Yan-Lei Zhang、Yong-Qiang Wang

  DOI：10.1016/j.tetlet.2013.03.043

  日期：2013.5

  A general and efficient aza-Michael reaction promoted by aqueous sodium carbonate solution has been developed. The reaction has complete mono-alkylation selectivity and proceeds with complete chirality retention for chiral amino esters. With a broad substrate scope, a well-common catalyst and simple operation, the catalytic approach provides a facile, practicable, economical, and environmentally benign method for the synthesis of beta-amino carbonyl compounds. (c) 2013 Elsevier Ltd. All rights reserved.
• DENIS G. I.; GURYAVICHENE YU. V.; CHEKUOLENE L. V.; STYAPONAVICHYUS YU. Y+, LIETTSR MOKSLU AKAD. DARVAI, TR. AN LITSSR, 1977, B, HO 1 (98), 33-38
  作者：DENIS G. I.、 GURYAVICHENE YU. V.、 CHEKUOLENE L. V.、 STYAPONAVICHYUS YU. Y+

  DOI：——

  日期：——