2-benzylimidazo[1,5-a]quinolinium chloride | 1034449-17-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-benzylimidazo[1,5-a]quinolinium chloride
• 英文别名: 2-benzylimidazo[1,5-a]quinolin-2-ium;chloride
• CAS: 1034449-17-6
• 化学式: C₁₈H₁₅N₂*Cl
• 分子量: 294.783
• InChiKey: IMLMRTJDPGTOBG-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.43
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  8.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  silver(l) oxide 、 2-benzylimidazo[1,5-a]quinolinium chloride 以 not given 为溶剂， 以96%的产率得到
  参考文献：
  名称：

  Imidazo[1,5-a]pyridine:  A Versatile Architecture for Stable N-Heterocyclic Carbenes

  摘要：

  The imidazo[1,5-a]pyridine skeleton provides a versatile platform for the generation of new types of stable N-heterocyclic carbenes. Rh(I) mono- (6) and biscarbenes (7) from imidazo[1,5-a]pyridin-3-ylidenes (ImPy) and derivatives such as 13 from a mesoionic carbene were synthesized and characterized.

  DOI：

  10.1021/ja0423769
• 作为产物：
  描述：

  N-苄基-N-(2-喹啉基甲基)甲酰胺 在 三氯氧磷 作用下， 以 甲苯 为溶剂， 以59%的产率得到2-benzylimidazo[1,5-a]quinolinium chloride
  参考文献：
  名称：

  Imidazo[1,5-a]pyridine:  A Versatile Architecture for Stable N-Heterocyclic Carbenes

  摘要：

  The imidazo[1,5-a]pyridine skeleton provides a versatile platform for the generation of new types of stable N-heterocyclic carbenes. Rh(I) mono- (6) and biscarbenes (7) from imidazo[1,5-a]pyridin-3-ylidenes (ImPy) and derivatives such as 13 from a mesoionic carbene were synthesized and characterized.

  DOI：

  10.1021/ja0423769

文献信息

• Method for treating neurological disorders with imidazolium and imidazolinium compounds
  申请人：Agency for Science, Technology and Research

  公开号：EP2803356A1

  公开（公告）日：2014-11-19

  There is presently provided methods for delivering a neuroprotective agent to a neural cell. The methods comprise contacting a neural cell with an imidazolium or imidazolinium compound as described herein, including an imidazolium or imidazolinium salt.

  目前提供了向神经细胞递送神经保护剂的方法。这些方法包括将神经细胞与本文所述的咪唑或咪唑啉化合物（包括咪唑盐或咪唑啉盐）接触。
• Ru/O₂-Catalyzed Oxidative C–H Activation/Alkyne Annulation Using Quinoline-Functionalized NHC as a Directing and Functionalizable Group
  作者：Monuranjan Konwar、Nitumoni Hazarika、Animesh Das

  DOI：10.1021/acs.orglett.4c00542

  日期：2024.4.19

  The ruthenium/O2-catalyzed oxidative annulation reaction of imidazo[1,5-a]quinolin-2-ium salts with alkynes via N-heterocyclic carbene-directed C–H activation to obtain π-conjugated fused imidazo[1,5-a]quinolin-2-ium derivatives is reported. Molecular oxygen has been explored as an economic and clean oxidant and an alternative to metal oxidants. The current protocol exhibits a wide range of substrate

  钌/O 2催化咪唑并[1,5- a ]喹啉-2-鎓盐与炔烃通过N-杂环卡宾引导的C-H活化发生氧化成环反应，得到π-共轭稠合咪唑[1,5-报道了a ]喹啉-2-鎓衍生物。分子氧已被探索作为一种经济且清洁的氧化剂以及金属氧化剂的替代品。当前的协议展示了广泛的底物范围，包括生物活性 (±)-α-生育酚衍生物。此外，大多数环状产品表现出很强的荧光特性，表明它们具有制造新型发光材料的潜力。
• METHOD FOR TREATING NEUROLOGICAL DISORDERS WITH IMIDAZOLIUM AND IMIDAZOLINIUM COMPOUNDS
  申请人：Zhuo Lang

  公开号：US20110028513A1

  公开（公告）日：2011-02-03

  There is presently provided methods for delivering a neuroprotective agent to a neural cell. The methods comprise contacting a neural cell with an imidazolium or imidazolinium compound as described herein, including an imidazolium or imidazolinium salt.
• METHOD FOR TREATING FIBROSIS AND CANCER WITH IMIDAZOLIUM AND IMIDAZOLINIUM COMPOUNDS
  申请人：Zhuo Lang

  公开号：US20110178040A1

  公开（公告）日：2011-07-21

  There is presently provided methods for delivering an anti-fibrotic or anti-cancer agent to a cell. The methods comprise contacting a cell with an effective amount of imidazolium and imidazolinium compounds as described herein, including imidazolium and imidazolinium salts.
• US9072729B2
  申请人：——

  公开号：US9072729B2

  公开（公告）日：2015-07-07