3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-hydroxy-1-methyl-ethyl)-methoxy-amide | 1245827-93-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-hydroxy-1-methyl-ethyl)-methoxy-amide
• 英文别名: 3-(difluoromethyl)-N-(1-hydroxypropan-2-yl)-N-methoxy-1-methylpyrazole-4-carboxamide
• CAS: 1245827-93-3
• 化学式: C₁₀H₁₅F₂N₃O₃
• 分子量: 263.244
• InChiKey: LWUIAWOQGVUXEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  67.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,4,6-三甲酚 、 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-hydroxy-1-methyl-ethyl)-methoxy-amide 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以27%的产率得到3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-2-(2,4,6-trimethyl-phenoxy)-ethyl]-amide
  参考文献：
  名称：

  [EN] N-HYDROXY-L-METHYL-LH-PYRAZOLE-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES
  [FR] DÉRIVÉS DE N-HYDROXY-L-MÉTHYL-LH-PYRAZOLE-4-CARBOXAMIDE ET LEUR UTILISATION COMME MICROBIOCIDES

  摘要：

  式(I)中的衍生物，其中取代基如权利要求1所定义的那样，适用于用作微生物杀灭剂。

  公开号：

  WO2010106071A1
• 作为产物：
  描述：

  3-(二氟甲基)-1-甲基-1H-吡唑-4-羰酰氯 、 2-(methoxyamino)propan-1-ol 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以4%的产率得到3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-hydroxy-1-methyl-ethyl)-methoxy-amide
  参考文献：
  名称：

  [EN] N-HYDROXY-L-METHYL-LH-PYRAZOLE-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES
  [FR] DÉRIVÉS DE N-HYDROXY-L-MÉTHYL-LH-PYRAZOLE-4-CARBOXAMIDE ET LEUR UTILISATION COMME MICROBIOCIDES

  摘要：

  式(I)中的衍生物，其中取代基如权利要求1所定义的那样，适用于用作微生物杀灭剂。

  公开号：

  WO2010106071A1

文献信息

• Fungicidal compositions
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：US10932466B2

  公开（公告）日：2021-03-02

  The present invention relates to novel fungicidal compositions for the treatment of phytopathogenic diseases of useful plants, especially phytopathogenic fungi, and to a method of controlling such phytopathogenic diseases on useful plants. In particular compositions suitable for control of diseases caused by phytopathogens comprise a mixture of a compound of formula (I) with a compound of formula (II) and a method of controlling diseases on useful plants using such compositions.

  本发明涉及用于治疗有用植物的植物病原性疾病，特别是植物病原真菌的新型杀菌组合物，以及控制有用植物上此类植物病原性疾病的方法。特别是适用于控制由植物病原菌引起的病害的组合物包括式（I）化合物的混合物 与式（II）化合物的混合物 以及使用此类组合物控制有用植物上病害的方法。
• FUNGICIDAL COMPOSITIONS
  申请人：Syngenta Participations AG

  公开号：EP2621277B1

  公开（公告）日：2017-12-06
• FUNGICIDAL COMPOSITIONS COMPRISING A CARBOXAMIDE
  申请人：Syngenta Participations AG

  公开号：US20190230925A1

  公开（公告）日：2019-08-01

  A method of controlling phytopathogenic diseases on useful plants or on propagation material thereof, which comprises applying to the useful plants, the locus thereof or propagation material thereof a combination of components (A) and (B) in a synergistically effective amount, wherein component (A) is a compound of formula I compound of formula I wherein R is hydrogen or methoxy; Q is R 1 is hydrogen, halogen or C 1 -C 6 alkyl; R 2 is hydrogen, halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 alkinyl, C 3 -C 6 cycloalkyl-C 3 -C 6 alkinyl, halophenoxy, halophenyl-C 3 -C 6 alkinyl, C(C 1 -C 4 alkyl)═NO—C 1 -C 4 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, C 2 -C 6 haloalkenyl, or C 2 -C 6 haloalkenyloxy; R 3 is hydrogen, halogen, C 1 -C 6 alkyl; R 4 , R 5 and R 6 , independently from each other, are hydrogen, halogen or —≡—R 7 ; with the proviso that at least one of R 4 , R 5 and R 6 is different from hydrogen; R 7 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 1 -C 4 alkoxyalkyl; and R 8 is hydrogen or methoxy; and agrochemically acceptable salts/isomers/structural isomers/stereoisomers/diastereoisomers/enantiomers/tautomers and N-oxides of those compounds; and component (B) is a compound selected from compounds known for their fungicidal and/or insecticidal activity, is particularly effective in controlling or preventing fungal diseases of useful plants.
• [EN] FUNGICIDAL COMPOSITIONS<br/>[FR] COMPOSITIONS FONGICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017207444A1

  公开（公告）日：2017-12-07

  The present invention relates to novel fungicidal compositions for the treatment of phytopathogenic diseases of useful plants, especially phytopathogenic fungi, and to a method of controlling such phytopathogenic diseases on useful plants. In particular compositions suitable for control of diseases caused by phytopathogens comprise a mixture of a compound of formula (I) with a compound of formula (II) and a method of controlling diseases on useful plants using such compositions.
• [EN] N-HYDROXY-L-METHYL-LH-PYRAZOLE-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES<br/>[FR] DÉRIVÉS DE N-HYDROXY-L-MÉTHYL-LH-PYRAZOLE-4-CARBOXAMIDE ET LEUR UTILISATION COMME MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2010106071A1

  公开（公告）日：2010-09-23

  Compounds of formula (I) in which the substituents are as defined in claim 1, are suitable for use as microbiocides.

  式(I)中的衍生物，其中取代基如权利要求1所定义的那样，适用于用作微生物杀灭剂。