4-propylsulfanyl-butan-2-one | 22842-75-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-propylsulfanyl-butan-2-one
• 英文别名: 4-(Propylthio)butan-2-one；4-propylsulfanylbutan-2-one
• CAS: 22842-75-7
• 化学式: C₇H₁₄OS
• 分子量: 146.254
• InChiKey: JIQCXLIYMOOSGJ-UHFFFAOYSA-N

物化性质

• 沸点：
  89-90 °C(Press: 8 Torr)
• 密度：
  0.942±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-propylsulfanyl-butan-2-one 、 甘油 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 以79.5%的产率得到[2-Methyl-2-(2-propylsulfanyl-ethyl)-[1,3]dioxolan-4-yl]-methanol
  参考文献：
  名称：

  Sabirov, S. S.; Gnevasheva, L. M.; Ismailov, M. I., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 1239 - 1243

  摘要：

  DOI：
• 作为产物：
  描述：

  丙烷-1-硫醇 、 丁烯酮 在 ammonium cerium(IV) nitrate air 作用下， 反应 0.33h， 以86%的产率得到4-propylsulfanyl-butan-2-one
  参考文献：
  名称：

  硝酸铈铵（CAN）作为绿色高效的助催化剂，用于将硫醇和苯硒酚加成到α，β-不饱和酮上的1,4-

  摘要：

  描述了一种温和而有效的方法，该方法使用催化量的CAN以优异的产品收率将硫醇和苯硒酚的1,4-加成成各种α，β-不饱和酮。这种廉价，无毒且容易获得的催化硝酸铈（IV）铵体系可在无溶剂条件下有效催化硫醇衍生物与各种α，β-不饱和酮之间的共轭加成反应。提出了一种可能的机制，即CAN在自由基链加成反应中作为促进剂以及在共轭加成过程中的催化作用。

  DOI：

  10.1016/j.tet.2006.12.018

文献信息

• Pyrazolopyridines and analogs thereof
  申请人：Hays S. David

  公开号：US20060100229A1

  公开（公告）日：2006-05-11

  Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

  吡唑吡啶-4-胺，吡唑喹啉-4-胺，吡唑萘啉-4-胺和6,7,8,9-四氢吡唑喹啉-4-胺，含有这些化合物的药物组合物，中间体，制备方法以及将这些化合物用作免疫调节剂的方法，用于诱导或抑制动物体内细胞因子生物合成，并用于治疗包括病毒性和肿瘤性疾病在内的疾病。
• ANTIMICROBIAL HYDROGELS, METHODS OF PREPARATION THEREOF, AND ARTICLES THEREFROM
  申请人：Coady Daniel Joseph

  公开号：US20120231060A1

  公开（公告）日：2012-09-13

  A covalently crosslinked hydrogel comprises a) three or more divalent poly(alkylene oxide) chains P′ covalently linked at respective first end units to a branched first core group C′, b) three or more divalent poly(alkylene oxide) chains P″ covalently linked at respective first end units to a branched second core group C″, the chains P″ comprising respective second end units which are covalently linked to between 0% and 100% of respective second end units of chains P′ by divalent linking groups L″, and c) at least one pendant cationic block copolymer chain A′-B′. A′-B′ comprises i) a divalent block A′ comprising a poly(alkylene oxide) backbone chain having an end unit covalently linked to a second end unit of one of the chains P′ by a divalent linking group L′, and ii) a monovalent block B′ comprising a first repeat unit, the first repeat unit comprising a backbone carbonate group and a cationic side chain group.

  一种共价交联的水凝胶包括a) 三个或更多个二价聚(烷氧基烷氧基)链P′，其在各自的第一端单元上共价连接到分支的第一核心基团C′，b) 三个或更多个二价聚(烷氧基烷氧基)链P″，其在各自的第一端单元上与分支的第二核心基团C″共价连接，链P″包括通过二价连接基团L″与链P′的各自第二端单元之间共价连接到0%至100%的各自第二端单元的第二端单元，以及c) 至少一个挂链阳离子嵌段共聚物链A′-B′。A′-B′包括i) 一个二价块A′，包括一个与链P′中的一个链的第二端单元通过二价连接基团L′共价连接的聚(烷氧基烷氧基)骨架链，以及ii) 一个一价块B′，包括第一个重复单元，该第一个重复单元包括一个骨架碳酸酯基团和一个阳离子侧链基团。
• PYRAZOLOPYRIDINES AND ANALOGS THEREOF
  申请人：Hays David S.

  公开号：US20090318435A1

  公开（公告）日：2009-12-24

  Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

  本文介绍了吡唑吡啶-4-胺，吡唑喹啉-4-胺，吡唑萘啉-4-胺和6,7,8,9-四氢吡唑喹啉-4-胺，含有这些化合物的药物组合物，中间体，制备方法以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物细胞因子生物合成，以及用于治疗包括病毒和肿瘤疾病在内的疾病。
• Pyrazolopyridines and Analogs Thereof
  申请人：Hays David S.

  公开号：US20090075980A1

  公开（公告）日：2009-03-19

  Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, and prodrugs thereof, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

  本文披露了吡唑吡啶-4-胺、吡唑喹啉-4-胺、吡唑萘啉-4-胺、6,7,8,9-四氢吡唑喹啉-4-胺及其前药、含有这些化合物的制药组合物、中间体、制备方法以及这些化合物作为免疫调节剂的使用方法，包括在动物中诱导或抑制细胞因子生物合成以及治疗病毒和肿瘤性疾病。
• The iron(III) chloride-mediated 1,4-addition of mercaptans to α,β-unsaturated ketones and esters under solvent free conditions
  作者：Cheng-Ming Chu、Wan-Ju Huang、Chaowei Lu、Pohsi Wu、Ju-Tsung Liu、Ching-Fa Yao

  DOI：10.1016/j.tetlet.2006.07.151

  日期：2006.10

  The 1,4-addition of various thiols to alpha,beta-unsaturated ketones was completed rapidly in the presence of a catalytic amount (2-3 mol %) of anhydrous iron(III) chloride under solvent free conditions and an air atmosphere. Anhydrous iron(III) chloride is more active than that of other ferric salts. With more reactive and/or less steric reagents (1a-c and/or 2a-2c), expeditious conditions (short reaction times at room temperature) could be employed. With less reactive and/or steric reagents (1d-g and/or 2d-e), a slight increase in reaction time was required, but high yields were obtained. The FeCl3 catalyst causes preferential interactions with alpha,beta-unsaturated ketones present in the reaction. (c) 2006 Published by Elsevier Ltd.