1-(Diphenylphosphino)-2-ethoxy-1-(2-pyridyl)ethane | 159597-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(Diphenylphosphino)-2-ethoxy-1-(2-pyridyl)ethane
• 英文别名: (2-Ethoxy-1-pyridin-2-ylethyl)-diphenylphosphane
• CAS: 159597-31-6
• 化学式: C₂₁H₂₂NOP
• 分子量: 335.386
• InChiKey: HMTBKGGCJFIBDP-UHFFFAOYSA-N

物化性质

• 沸点：
  449.2±40.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tris(triphenylphosphine)ruthenium(II) chloride 、 1-(Diphenylphosphino)-2-ethoxy-1-(2-pyridyl)ethane 以 二氯甲烷 为溶剂， 以73%的产率得到
  参考文献：
  名称：

  含有光学活性半不稳定P，N，O-三叉形配体的钌（II）配合物。丙-2-醇催化苯乙酮不对称转移加氢反应的合成与评价

  摘要：

  三官能配体（R）-1-（二苯基膦基）-2-（（1 R，2 S，5 R）-薄荷醇）-1-（2-吡啶基）乙烷（2R），（S）-1-（二苯基膦基）-2-（（（1 R，2 S，5 R）-薄荷醇）-1-（2-吡啶基）乙烷（2S）和（S）-（苯基（2-茴香基）膦基）（2-吡啶基）合成了甲烷（3）以及相应的RuCl 2（PPh 3）（L）配合物。RuCl 2（PPh 3）（2R）（5）和RuCl 2的络合物（PPh 3）（2S）（6）分别作为两种异构体5a和5b以及6a和6b的混合物分离出来。在每一个这些异构体的，配体2是η 3 -结合（P，N，O）。它们的区别在于三苯基膦的位置，相对于吡啶环的反式位置（5a或6a）或相对于醚官能的反式位置（5b或6b）。可变温度NMR实验表明，配体2的溶液具有半不稳定特性通过异构体a中的吡啶基臂或b中的醚臂。通过X射线衍射表征络合物6b和RuCl 2（PPh 3）（3

  DOI：

  10.1021/om960955j
• 作为产物：
  描述：

  二苯基氯化膦 在 正丁基锂 、 苯基锂 作用下， 以 乙醚 为溶剂， 反应 3.0h， 生成 1-(Diphenylphosphino)-2-ethoxy-1-(2-pyridyl)ethane
  参考文献：
  名称：

  Synthesis and evaluation of the bonding properties of a potentially tridentate ligand: 1-(diphenylphosphino)-2-ethoxy-1-(2-pyridyl)ethane

  摘要：

  The trifunctional ligand 1 (diphenylphosphino)-2-ethoxy-1-(2-pyridyl)ethane (pepye) has been prepared and its bonding properties toward Mo0, Rh(I) and Ru(II) metallic centres evaluated. The complex fac-[Mo(CO)3(pepye)] in which the ligand is P,N,O bonded in solution evolves to cis-[Mo(CO)4-(pepye)] where it is P,N bonded. In the complex [Rh(cod)(pepye)]ClO4 (cod = cycloocta-1,5-diene) the ligand is P,N bonded. The cycloocta-1,5-diene can be displaced by carbon monoxide, and [Rh(CO)2(pepye)]ClO4 and [{Rh(CO)(pepye)}2] [ClO4]2 have been isolated. In the former the ligand is P,N bonded and in the latter the two rhodium atoms are bridged by the phosphine and ether functions of each ligand. The complex all-cis-[RuCl2(pepye)2] has been isolated in two diastereoisomeric forms in a 6:4 ratio. In polar solvents it evolves to [RuCl(pepye)2]+ in which one of the ligands is P,N,O bonded and the two diastereoisomers have been isolated as their tetraphenylborate salts. The bonded ether arm of the ligand can be displaced by carbon monoxide leading to [RuCl(CO)(pepye)2]BPh4. This reaction can be reversed in boiling acetone, more or less easily, depending upon the diastereoisomers.

  DOI：

  10.1039/dt9940002755

文献信息

• IMPROVED PROCESS FOR REDUCTIVE HYDROLYSIS OF NITRILES
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0807098B1

  公开（公告）日：1998-09-09
• US5741955A
  申请人：——

  公开号：US5741955A

  公开（公告）日：1998-04-21
• [EN] IMPROVED PROCESS FOR REDUCTIVE HYDROLYSIS OF NITRILES<br/>[FR] PROCEDE AMELIORE D'HYDROLYSE DE NITRILES PAR REDUCTION
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：WO1996023753A1

  公开（公告）日：1996-08-08

  (EN) This invention concerns processes for the reductive hydrolysis of nitriles to alcohols utilizing as a catalyst a transition metal complex of the formula MHZ(CO)Ln(PR3)2 wherein: M is a transition metal selected from the group consisting of: Fe, Ru and Os; Z is an anionic ligand; L is a neutral ligand; n is 0 or 1; and PR3 is a phosphine ligand.(FR) La présente invention concerne des procédés d'hydrolyse de nitriles par réduction, donnant des alcools, avec comme catalyseur un complexe métallique de transition ayant pour formule MHZ(CO)Ln(PR3)2, M étant un métal de transition choisi dans le groupe constitué par le fer, le ruthénium et l'osmium, Z étant un coordinat anionique, L étant un coordinat neutre, n étant égal à 0 ou 1, et PR3 étant un coordinat de phosphine.
• Synthesis and evaluation of the bonding properties of a potentially tridentate ligand: 1-(diphenylphosphino)-2-ethoxy-1-(2-pyridyl)ethane
  作者：Marie Alvarez、No�l Lugan、Ren� Mathieu

  DOI：10.1039/dt9940002755

  日期：——

  The trifunctional ligand 1 (diphenylphosphino)-2-ethoxy-1-(2-pyridyl)ethane (pepye) has been prepared and its bonding properties toward Mo0, Rh(I) and Ru(II) metallic centres evaluated. The complex fac-[Mo(CO)3(pepye)] in which the ligand is P,N,O bonded in solution evolves to cis-[Mo(CO)4-(pepye)] where it is P,N bonded. In the complex [Rh(cod)(pepye)]ClO4 (cod = cycloocta-1,5-diene) the ligand is P,N bonded. The cycloocta-1,5-diene can be displaced by carbon monoxide, and [Rh(CO)2(pepye)]ClO4 and [Rh(CO)(pepye)}2] [ClO4]2 have been isolated. In the former the ligand is P,N bonded and in the latter the two rhodium atoms are bridged by the phosphine and ether functions of each ligand. The complex all-cis-[RuCl2(pepye)2] has been isolated in two diastereoisomeric forms in a 6:4 ratio. In polar solvents it evolves to [RuCl(pepye)2]+ in which one of the ligands is P,N,O bonded and the two diastereoisomers have been isolated as their tetraphenylborate salts. The bonded ether arm of the ligand can be displaced by carbon monoxide leading to [RuCl(CO)(pepye)2]BPh4. This reaction can be reversed in boiling acetone, more or less easily, depending upon the diastereoisomers.
• Ruthenium(II) Complexes Containing Optically Active Hemilabile P,N,O-Tridentate Ligands. Synthesis and Evaluation in Catalytic Asymmetric Transfer Hydrogenation of Acetophenone by Propan-2-ol
  作者：Hong Yang、Marie Alvarez-Gressier、Noël Lugan、René Mathieu

  DOI：10.1021/om960955j

  日期：1997.4.1

  respectively. In each of these isomers, the ligands 2 are η3-(P,N,O) bound. They differ by the position of the triphenylphosphine, which is either in a trans position relative to the pyridyl ring (5a or 6a) or in a trans position relative to the ether function (5b or 6b). Variable temperature NMR experiments have shown that the hemilabile character in solution of the ligands 2 is through their pyridyl arm in

  三官能配体（R）-1-（二苯基膦基）-2-（（1 R，2 S，5 R）-薄荷醇）-1-（2-吡啶基）乙烷（2R），（S）-1-（二苯基膦基）-2-（（（1 R，2 S，5 R）-薄荷醇）-1-（2-吡啶基）乙烷（2S）和（S）-（苯基（2-茴香基）膦基）（2-吡啶基）合成了甲烷（3）以及相应的RuCl 2（PPh 3）（L）配合物。RuCl 2（PPh 3）（2R）（5）和RuCl 2的络合物（PPh 3）（2S）（6）分别作为两种异构体5a和5b以及6a和6b的混合物分离出来。在每一个这些异构体的，配体2是η 3 -结合（P，N，O）。它们的区别在于三苯基膦的位置，相对于吡啶环的反式位置（5a或6a）或相对于醚官能的反式位置（5b或6b）。可变温度NMR实验表明，配体2的溶液具有半不稳定特性通过异构体a中的吡啶基臂或b中的醚臂。通过X射线衍射表征络合物6b和RuCl 2（PPh 3）（3