2-chloro-1-decanol | 121579-91-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 2-chloro-1-decanol
• 英文别名: 2-chlorodecan-1-ol
• CAS: 121579-91-7
• 化学式: C₁₀H₂₁ClO
• 分子量: 192.729
• InChiKey: HYXXMRRYNVDSRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,2-二甲基丁炔酯 生成 2-chloro-1-decanol
  参考文献：
  名称：

  CIACCIO J. A.; ADDESS K. J.; BELL T. W., TETRAHEDRON LETT., 27,(1986) N 32, 3697-3700

  摘要：

  DOI：

文献信息

• Selective Generation of Free Radicals from Epoxides Using a Transition-Metal Radical. A Powerful New Tool for Organic Synthesis
  作者：T. V. RajanBabu、William A. Nugent

  DOI：10.1021/ja00082a021

  日期：1994.2

  halogens provides a route to functionalized cyclopentanes and other useful products. The radical initially formed from an epoxide can also be trapped by H-atom donors such as 1,4- cyclohexadiene or tert-butyl thiol, resulting in an overall reduction of the epoxide. In the absence of a H-atom donor or an olefin, this radical is trapped by Ti(", resulting in a fl-oxido-Ti organometallic species which undergoes

  双（环戊二烯基）氯化钛 (III) 通过初始 C-0 均裂与环氧化物反应。开口的区域化学由自由基的相对稳定性决定。根据反应伙伴的不同，这些自由基会发生分子内（己-5-烯基环化）或分子间加成到烯烃的过程。生成的自由基被第二当量的 Ti(II1) 有效清除，得到相应的 Ti(1V) 衍生物。用亲电试剂（如 H+ 或卤素）处理该中间体提供了获得官能化环戊烷和其他有用产品的途径。最初由环氧化物形成的自由基也可以被 H 原子供体如 1,4- 环己二烯或叔丁基硫醇捕获，导致环氧化物的整体还原。在没有氢原子供体或烯烃的情况下，环氧化物作为有机合成的构件的相当大的效用反映了它们的现成可用性和它们进行具有可预测立体化学的选择性亲核取代反应(eq la)的能力。相比之下，两 环氧化物作为有机合成的构件的相当大的效用反映了它们的现成可用性和它们进行具有可预测立体化学的选择性亲核取代反应(eq la)的能力。相比之下，两
• Metal-assisted reactions—Part 11
  作者：Ian D. Entwistle、Robert A.W. Johnstone、Anna H. Wilby

  DOI：10.1016/0040-4020(82)80184-1

  日期：1982.1

  The rapid reduction of N-nitrosoamines to N,N-disbustituted hydrazines by a low-vanet titanium reagent is described. The reagent is selective in that many other functional groups are unaffected by it. The nature of the low-valent titanium reagent is discussed in terms of experimental results of comparisons of its reactivity and that of other low-valent titanium reducing agents.

  描述了通过低气孔钛试剂将N-亚硝基胺快速还原成N，N-不饱和的肼。该试剂是选择性的，因为许多其他官能团不受其影响。通过比较其反应性与其他低价钛还原剂的反应性的实验结果来讨论低价钛试剂的性质。
• METHOD FOR SYNTHESIS OF HALOPYRIDYL-ACYCLOPENTANE DERIVATIVE AND INTERMEDIATE THEREOF
  申请人：——

  公开号：US20020010339A1

  公开（公告）日：2002-01-24

  The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

  本发明涉及一种合成光学活性卤代吡啶-氮杂环戊烷衍生物及其中间体的方法，包括从光学活性丙酮二羧酸酯衍生物制备光学活性联二烯-1,3-二羧酸酯衍生物，然后通过7-氮杂双环[2.2.1]庚烷衍生物进行反应，以获得目标产物。
• Novel organic selenium compounds
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP0222414A2

  公开（公告）日：1987-05-20

  This invention relates to the novel selenium compounds which are useful as an antineoplastic agent. The compounds are represented by the general formula (1): wherein R, X, A and Y represent the groups specified below, a represents a number of 0 or 1, b represents a number of 0, 1 or 2, and (1) when a is 0 and b is also 0, c is 4, n is 1 or 2 and m is 0, (2) when a is 1 and b is 0, c is 2, n is 1 or 2 and m is 0 or 1, and (3) when b is 1 or 2, c, n and m are all 0; (i) when b is 2, R represents (1) a C4-10 alkoxy group substituted with a halogen atom, (2) a lower alkoxyl group substituted with a halogen atom and a phenyl group, or (3) a cycloalkyloxy group substituted with a halogen atom, and (ii) when b is 1, R represents a group represented by the formula (wherein Ro is a C2-6 alkyl group); X represents a halogen atom; A represents caffeine, theophylline, N-benzyltheophylline, N-benzyltheobromine, 2,2'-biquinoline, 1,6-naphthylidine, 1,10-phenanthroline, or a compound represented by the formula or (wherein R, and R2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkyl group, a halogen atom, a phenyl group, a cyano group, a lower alkoxycarbonyl group, a phenoxycarbonyl group, an amino group (to which a lower alkyl, lower alkylaminocarbonyl, lower halogenoalkylaminocarbonyl or lower alkoxycarbonyl group may be bonded), a benzoyl group, a loweralkoxyl group, a carbamyl group or an allyloxycarbonyl group; R3 represents a C1-10 alkyl group or a benzyl group; R. and R5 represent independently a hydrogen atom, a halogen atom or an alkyl group, or R4 and R5 may represent in combination; R6 represents a lower alkoxyl group, a phenyl group or a phenoxy group; R7 represents a hydrogen atom, a lower alkyl group or a group represented by the formula (wherein R9 represents an amino group or a lower alkoxyl group); R10 represent a hydrogen atom or a nitro group; and one of B and D represents nitrogen and the other represents ≥C-H or ≥C-OH); and Y represents H2O or an alcohol represented by the formula R8-OH [wherein R8 represents a benzyl (which may be substituted with a lower alkoxy group) or alkyl group]; wherein when X is chlorine atom and m is 0, R1 and R10 represent an atom or a group other than hydrogen atom.

  本发明涉及可用作抗肿瘤剂的新型硒化合物。这些化合物由通式（1）表示： 其中 R、X、A 和 Y 代表下面规定的基团，a 代表 0 或 1，b 代表 0、1 或 2，(1) 当 a 为 0 且 b 也为 0 时，c 为 4，n 为 1 或 2，m 为 0，(2) 当 a 为 1 且 b 为 0 时，c 为 2，n 为 1 或 2，m 为 0 或 1，(3) 当 b 为 1 或 2 时，c、n 和 m 均为 0； (i) 当 b 为 2 时，R 代表 (1) 被卤素原子取代的 C4-10 烷氧基，(2) 被卤素原子和苯基取代的低级烷氧基，或 (3) 被卤素原子取代的环烷氧基，和 (ii) 当 b 为 1 时，R 代表由式 1 所代表的基团。 (其中 Ro 为 C2-6 烷基）； X 代表卤原子； A 代表咖啡因、茶碱、N-苄基茶碱、N-苄基溴茶碱、2,2'-联喹啉、1,6-萘啶、1,10-菲罗啉或由式表示的化合物 或 (其中 R 和 R2 可以相同或不同，并代表氢原子、羟基、低级烷基、卤素原子、苯基、氰基、低级烷氧基羰基、苯氧基羰基、氨基（可键合低级烷基、低级烷基氨基羰基、低级卤代烷基氨基羰基或低级烷氧基羰基）、苯甲酰基、低级烷氧基基、氨基甲酰基或烯丙氧基羰基；R3 代表 C1-10 烷基或苄基； R.和 R5 独立地代表氢原子、卤素原子或烷基，或 R4 和 R5 可结合代表 R6代表低级烷氧基、苯基或苯氧基； R7代表氢原子、低级烷基或由以下式子表示的基团 (其中 R9 代表氨基或低级烷氧基）； R10 代表氢原子或硝基；B 和 D 中的一个代表氮，另一个代表 ≥C-H 或 ≥C-OH）；以及 Y 代表 H2O 或由式 R8-OH 所代表的醇[其中 R8 代表苄基（可被低级烷氧基取代）或烷基]； 其中，当 X 为氯原子且 m 为 0 时，R1 和 R10 代表氢原子以外的原子或基团。
• Regio- and Stereoselective Synthesis of β-Halohydrins from 1,2-Epoxides with Ammonium Halides in the Presence of Metal Salts
  作者：Marco Chini、Paolo Crotti、Cristina Gardelli、Franco Macchia

  DOI：10.1016/s0040-4020(01)92271-9

  日期：1992.1

  A simple efficient, stereoselective, and regioselective method for the synthesis of beta-chlorohydrins, beta-bromohydrins, and beta-iodohydrins by the direct opening of 1,2-epoxides with the corresponding ammonium halide in acetonitrile, in the presence of metal salts. is described. This new method appears to be of general use and competitive with the other methods previously reported.