4,4-dimethyl-hexan-3-ol | 19550-09-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,4-dimethyl-hexan-3-ol
• 英文别名: 4,4-Dimethyl-3-hexanol；4,4-dimethylhexan-3-ol
• CAS: 19550-09-5
• 化学式: C₈H₁₈O
• 分子量: 130.23
• InChiKey: BARKHVPKOOSMNW-UHFFFAOYSA-N

物化性质

• 沸点：
  160-160.4 °C(Press: 758 Torr)
• 密度：
  0.8341 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4,4-dimethyl-hexan-3-ol 在 platinum on activated charcoal 、 磷酸 作用下， 生成 3,3-二甲基已烷
  参考文献：
  名称：

  Lewina et al., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1951, p. 321,325

  摘要：

  DOI：
• 作为产物：
  描述：

  magnesium,2-methylbutane,chloride 、 丙醛 在 乙醚 作用下， 生成 4,4-dimethyl-hexan-3-ol
  参考文献：
  名称：

  Lewina et al., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1951, p. 321,325

  摘要：

  DOI：

文献信息

• AMINOTHIAZOLE DERIVATIVE
  申请人：Yabuuchi Tetsuya

  公开号：US20120220767A1

  公开（公告）日：2012-08-30

  A compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which has a PI3 kinase γ inhibitory effect and is useful as a prophylactic or therapeutic agent for articular rheumatism, Crohn's disease, irritable colitis, Sjoegren's syndrome, multiple sclerosis, systemic lupus erythematosus, asthma, atopic dermatitis, arteriosclerosis, organ transplant rejection, cancer, retinopathy, psoriasis, arthrosis deformans, age-related macular degeneration, type II diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hyperlipemia, etc.

  由式（1）表示的化合物或其药学上可接受的盐，具有PI3激酶γ抑制作用，可用作关节风湿、克罗恩病、肠易激综合征、干燥综合征、多发性硬化、系统性红斑狼疮、哮喘、特应性皮炎、动脉硬化、器官移植排斥、癌症、视网膜病变、牛皮癣、关节病变、年龄相关性黄斑变性、2型糖尿病、胰岛素抵抗、肥胖、非酒精性脂肪肝病（NAFLD）、非酒精性脂肪性肝炎（NASH）、高脂血症等疾病的预防或治疗剂。
• BETULONIC AND BETULINIC ACID DERIVATIVES
  申请人：LEUNIS JEAN-CLAUDE

  公开号：US20140066416A1

  公开（公告）日：2014-03-06

  The present invention relates to betulonic and betulinic acid derivatives and, in particular, to C-28 and C-3 derivatives. The present invention relates to betulonic acid esters, and dihydro-betulonic acid esters. Betulinic acid and derivatives thereof may be bound to a poly(alkylene glycol) (PAG) such as poly(ethylene glycol). Binding may be via a linker, such as a diamine, an amino acid, a peptide, an ester or a carbonate. The compounds of the present invention may be used for the treatment of cancer or a viral infection. The present invention also provides pharmaceutical compositions comprising the compounds of the present invention.

  本发明涉及白桦酸和桦酸衍生物，特别是C-28和C-3衍生物。本发明涉及白桦酸酯和二氢白桦酸酯。白桦酸及其衍生物可以与聚（烷基醚）（PAG），如聚（乙二醇）结合。结合可以通过连接剂，如二胺，氨基酸，肽，酯或碳酸酯来实现。本发明的化合物可用于治疗癌症或病毒感染。本发明还提供了包含本发明的化合物的制药组合物。
• Process for producing alcohols and ketones
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0531715A1

  公开（公告）日：1993-03-17

  The present invention provides a process for the oxidation of straight-chain, branched-chain or cyclic alkanes of 1-20 carbon atoms and benzene derivatives represented by the following formulas (1) - (2). The alcohols and ketones obtained by the oxidation of the alkanes mentioned above and those by the oxidation of the benzene derivatives mentioned above represented by the following formulas (3) - (6) are important as basic starting materials in producing various chemical products including resins, such as nylon and polyester, pharmaceuticals, agricultural chemicals, perfumes, dyes, etc.

  本发明提供了一种氧化 1-20 个碳原子的直链、支链或环状烷烃以及由下列式子 (1) - (2) 表示的苯衍生物的工艺。由上述烷烃氧化得到的醇和酮以及由下列式子（3）-（6）表示的上述苯衍生物氧化得到的醇和酮是生产各种化学产品的重要基本起始原料，包括树脂（如尼龙和聚酯）、药品、农药、香水、染料等。
• VERFAHREN ZUR HERSTELLUNG VON MENTHONEN AUS ISOPULEGOL IN DER GASPHASE
  申请人：BASF SE

  公开号：EP3114104A1

  公开（公告）日：2017-01-11
• METHOD FOR PRODUCING MENTHONES FROM ISOPULEGOL IN THE GAS PHASE
  申请人：BASF SE

  公开号：US20170066705A1

  公开（公告）日：2017-03-09

  The present invention relates to a process for reacting isopulegol to menthone in the gas phase and to the use of the reaction products thus prepared as additives in foods, cosmetics, pharmaceutical products, tobacco formulations, household products, and laundry care products.

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