ethyl 2-oxo-3,3-diphenylpropanoate | 6362-64-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-oxo-3,3-diphenylpropanoate
• 英文别名: diphenyl-pyruvic acid ethyl ester；Diphenyl-brenztraubensaeure-aethylester；Ethyl 2-oxo-3,3-diphenyl-propanoate
• CAS: 6362-64-7
• 化学式: C₁₇H₁₆O₃
• 分子量: 268.312
• InChiKey: XVQKLEJDXHHYMZ-UHFFFAOYSA-N

物化性质

• 沸点：
  202 °C(Press: 13 Torr)
• 密度：
  1.1344 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 2-oxo-3,3-diphenylpropanoate 在 palladium on activated charcoal 作用下， 生成 2-羟基-3,3-二苯基丙酸
  参考文献：
  名称：

  Antispasmodics. XVI. β-Diethylaminoethyl Esters of Substituted Lactic and Acrylic Acids

  摘要：

  DOI：

  10.1021/ja01641a013
• 作为产物：
  描述：

  3,3-二苯基环氧乙烷-2-羧酸乙酯 在 盐酸 作用下， 生成 ethyl 2-oxo-3,3-diphenylpropanoate
  参考文献：
  名称：

  Antispasmodics. XVI. β-Diethylaminoethyl Esters of Substituted Lactic and Acrylic Acids

  摘要：

  DOI：

  10.1021/ja01641a013

文献信息

• Pyruvate Enolate Arylation and Alkylation: OBO Ester Protected Pyruvates as Useful Reagents in Organic Synthesis
  作者：C. Henrique Alves Esteves、Christopher J. J. Hall、Peter D. Smith、Timothy J. Donohoe

  DOI：10.1021/acs.orglett.7b02524

  日期：2017.10.6

  A protected pyruvate equivalent is described that allows arylation and arylation/alkylation reactions to be performed at the methyl group. Utilization of the OBO derivative of the pyruvate ester allowed the application of palladium catalyzed arylation reactions together with subsequent alkylation, under basic conditions. Moreover, the OBO protecting group could be easily removed in one step to provide

  描述了一种保护的丙酮酸酯当量，其允许在甲基上进行芳基化和芳基化/烷基化反应。丙酮酸酯的OBO衍生物的使用允许在碱性条件下进行钯催化的芳基化反应以及随后的烷基化。而且，可以很容易地在一个步骤中除去OBO保护基，以提供对广泛范围内取代的丙酮酸酯衍生物的接触。
• Os isotope systematics of komatiitic basalts from the Vetreny belt, Baltic Shield: evidence for a chondritic source of the 2.45 Ga plume
  作者：I. Puchtel、G. Brügmann、A. Hofmann、V. Kulikov、V. Kulikova

  DOI：10.1007/s004100000203

  日期：2001.2

  The Vetreny belt in the southeast Baltic Shield is a large volcano-sedimentary basin containing a 4- to 8-km-thick sequence of basaltic to komatiitic lavas, which were erupted similar to2.45 Ga ago in a continental rift setting during the interaction of a mantle plume and the Archean continental crust of the Karelian granite-greenstone terrane. Re-Os isotope data for olivine cumulate samples and chromite separates from Victoria's lava lake and Golets flow 3 define isochrons with ages of 2387 +/- 57 and 2432 +/- 34 Ma, respectively. These ages are in good agreement with the previously reported, and new, Nd-Pb and U-Pb zircon ages. These data, coupled with the evidence for immobile behavior of the Re and Os, indicate that the Re-Os system remained closed since the lava eruption. The weighted average initial gamma (187)Os values range between -0.43 +/- 0.10 for Golets flow 3 and -0.07 +/- 0.13 for the lava lake. A single chromite separate from Golets flow 1 has a gamma (187)Os(T) of -0.06 +/- 0.15. Nd-Pb isotope and lithophile trace element data for the Vetreny belt komatiitic basalts were used to monitor the effect of crustal contamination on the Os isotope system and to estimate the initial Os isotope composition of the Vetreny plume source to be approximately chondritic with a gamma (187)Os(T) of -0.9. This implies that the mantle source evolved with a long-term nearly chondritic Re/Os ratio. The data provide further evidence that, by the end of the late Archean, the Earth's upper mantle was well homogenized with respect to the highly siderophile elements, added during the accretion of a late veneer, on a time scale of similar to1 Ga.
• Ecary, Annales de Chimie (Cachan, France), 1948, vol. <12> 3, p. 445,462
  作者：Ecary

  DOI：——

  日期：——
• Troell, Chemische Berichte, 1928, vol. 61, p. 2501
  作者：Troell

  DOI：——

  日期：——
• THE ACTION OF ORGANIC MAGNESIUM COMPOUNDS ON ALPHA OXIDO KETONES AND ESTERS
  作者：E. P. Kohler、N. K. Richtmyer、W. F. Hester

  DOI：10.1021/ja01352a028

  日期：1931.1.1