methyl-5 hexadiene-3,5 one (Z) | 92180-71-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl-5 hexadiene-3,5 one (Z)
• 英文别名: (3Z)-5-methylhexa-3,5-dien-2-one
• CAS: 92180-71-7
• 化学式: C₇H₁₀O
• 分子量: 110.156
• InChiKey: XUUGSSQXYWMELT-PLNGDYQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  methyl-5 hexadiene-3,5 one (Z) 生成 dimethyl-3,6 2H-pyranne
  参考文献：
  名称：

  LHOSTE, P.;MOREAU, M.;DREUX, J., TETRAHEDRON, 1984, 40, N 9, 1551-1561

  摘要：

  DOI：
• 作为产物：
  描述：

  5-甲基-3,6-二氢-吡喃-2-酮 、 甲基碘化镁 、 水 生成 methyl-5 hexadiene-3,5 one (Z)
  参考文献：
  名称：

  LHOSTE, P.;MOREAU, M.;DREUX, J., TETRAHEDRON, 1984, 40, N 9, 1551-1561

  摘要：

  DOI：

文献信息

• Action des composes organomagnesiens sur les pyrones-2-VII
  作者：P. Lhoste、M. Moreau、J. Dreux

  DOI：10.1016/s0040-4020(01)91804-6

  日期：1984.1

  In the reaction between organomagnesium compounds and 2-pyrones, the relative stability of the 6-hydroxy 5,6-dihydro 2H-pyrans and their tautomeric forms (ketols) has no influence on the reaction pathway. When ethylenic ketols are obtained, the corresponding tautomeric dihydropyranols are prepared in a selective way by reaction of nucleophilic reagents on the 3,6-dihydro-2-pyrones. In the other hand

  在有机镁化合物与2-吡喃酮之间的反应中，6-羟基5,6-二氢2H-吡喃及其互变异构形式（酮醇）的相对稳定性对反应途径没有影响。当获得烯属酮醇时，通过亲核试剂在3，6-二氢-2-吡喃酮上的反应选择性地制备相应的互变异构二氢吡喃醇。另一方面，在这两个反应过程中，二氢吡喃酚或不饱和酮醇E的排他性形成表明，在实验条件下，这两个实体之间没有平衡。
• Probe array
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1352976B1

  公开（公告）日：2012-09-12
• LUBRICATING OIL COMPOSITION
  申请人：MATSUI Shigeki

  公开号：US20080110799A1

  公开（公告）日：2008-05-15

  The present invention provide a lubricating oil composition suitable for internal combustion engines, which composition is excellent in thermal/oxidation stability and can inhibit the increases of the viscosity and acid number even in the presence of NOx and can be used for a long period of time or provide a lubricating oil composition particularly suitable for diesel or direct injection engines equipped with an exhaust-gas after-treatment device such as DPF or various catalysts, which composition is excellent in high-temperature detergency and base number retention properties and further can achieve the effect of inhibit wear caused by soot contamination in the oil occurring significantly when the content of phosphorus compounds such as ZnDTP is decreased, at a high level and can inhibit the exhaust-gas after-treatment device from being adversely affected. The lubricating oil composition comprises a lubricating base oil containing, a specific amount of a base oil with specific properties, and two or more types of additives selected from specific additives.
• CBI DERIVATIVES SUBJECT TO REDUCTIVE ACTIVATION
  申请人：Boger Dale

  公开号：US20110112163A1

  公开（公告）日：2011-05-12

  A unique class of N-acyl O-amino phenol prodrugs of CBI-TMI and CBI-indole 2 were synthesized and shown to be prodrugs, subject to reductive activation by nucleophilic cleavage of a weak N—O bond, effectively releasing the free drug in functional cellular assays for cytotoxic activity approaching or matching the activity of the free drug, yet remain essentially stable to ex vivo DNA alkylation conditions. Most impressively, assessment of the in vivo antitumor activity of a representative O-(acylamino) prodrug, 8, indicate that they approach the potency and exceed the efficacy of the free drug itself (CBI-indole 2 ), indicating that the inactive prodrugs not only effectively release the free drug in vivo, but that they offer additional advantages related to a controlled or targeted release in vivo.
• US8026199B2
  申请人：——

  公开号：US8026199B2

  公开（公告）日：2011-09-27