申请人:MANOHARAN Muthiah
公开号:US20100179309A1
公开(公告)日:2010-07-15
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a carbohydrate; or a steroid, e.g., cholesterol, which is optionally substituted with at least one carbohydrate. is directly, or indirectly, tethered. The invention also relates to methods of making and using such modified iRNA agents.
本发明涉及iRNA剂,其中最好包括一个单体,其中核糖基团已被替换为除核糖外的基团。包含这样的单体可以允许调节iRNA剂的某种特性,例如,通过使用非核糖基团作为配体或其他实体(例如,碳水化合物或类固醇,例如胆固醇,可选择地取代至少一个碳水化合物)的点来直接或间接地牵引。本发明还涉及制备和使用这种修改的iRNA剂的方法。