1-(4-(2-(dimethylamino)benzo[d]oxazol-5-yl)phenyl)ethanone | 1404370-54-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-(2-(dimethylamino)benzo[d]oxazol-5-yl)phenyl)ethanone
• 英文别名: 1-[4-[2-(Dimethylamino)-1,3-benzoxazol-5-yl]phenyl]ethanone；1-[4-[2-(dimethylamino)-1,3-benzoxazol-5-yl]phenyl]ethanone
• CAS: 1404370-54-2
• 化学式: C₁₇H₁₆N₂O₂
• 分子量: 280.326
• InChiKey: GEMLHDLNDINTHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  46.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(4-(benzoxazol-5-yl)phenyl)ethanone 、 二甲胺基磺酰氯 在 potassium dichromate 、 (2,2-联吡啶)二氯钯(II) 、 copper(l) cyanide 、 potassium carbonate 作用下， 以 氯苯 为溶剂， 反应 24.0h， 以48%的产率得到1-(4-(2-(dimethylamino)benzo[d]oxazol-5-yl)phenyl)ethanone
  参考文献：
  名称：

  Palladium–copper-catalyzed desulfitative amination of benzo[d]oxazole C–H bond

  摘要：

  An efficient palladium-copper-catalyzed direct C-H amination of substituted benzoxazoles with various sulfamoyl chlorides as nitrogen group sources has been developed. The system does not need a strong base and tolerates a series of functional groups, such as chloro, methyl, and nitro groups, providing the amination products in moderate to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.044

文献信息

• Palladium–copper-catalyzed desulfitative amination of benzo[d]oxazole C–H bond
  作者：Shuyou Chen、Kui Zheng、Fan Chen

  DOI：10.1016/j.tetlet.2012.09.044

  日期：2012.11

  An efficient palladium-copper-catalyzed direct C-H amination of substituted benzoxazoles with various sulfamoyl chlorides as nitrogen group sources has been developed. The system does not need a strong base and tolerates a series of functional groups, such as chloro, methyl, and nitro groups, providing the amination products in moderate to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.