8-(2-pyridylmethoxy)quinoline | 622828-38-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-(2-pyridylmethoxy)quinoline
• 英文别名: 8-(pyridin-2-ylmethoxy)quinoline
• CAS: 622828-38-0
• 化学式: C₁₅H₁₂N₂O
• 分子量: 236.273
• InChiKey: YAHCEAHJGSZTLP-UHFFFAOYSA-N

物化性质

• 沸点：
  408.9±25.0 °C(Predicted)
• 密度：
  1.213±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.066
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-(2-pyridylmethoxy)quinoline 、 palladium dichloride 以 甲醇 、 乙腈 为溶剂， 以66%的产率得到[Pd(II)Cl2(8-(2-pyridylmethoxy)quinoline)]
  参考文献：
  名称：

  Muna, R. A.; Al-Mandhary; Steel, Peter J., Inorganica Chimica Acta, 2003, vol. 351, p. 7 - 11

  摘要：

  DOI：

文献信息

• SUBSTITUTED PYRIMIDINYL OXIME KINASE INHIBITORS
  申请人：Xu Guozhang

  公开号：US20070270425A1

  公开（公告）日：2007-11-22

  The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.

  本发明涉及公式（I）的取代嘧啶化合物及其形式，它们的合成和用于治疗、预防或改善慢性或急性蛋白激酶介导的疾病、疾病或病况。
• Substituted Pyrimidinyl Oxime Kinase Inhibitors
  申请人：Battista Kathleen A.

  公开号：US20120157412A1

  公开（公告）日：2012-06-21

  The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.

  本发明涉及式(I)的取代嘧啶化合物及其形式，它们的合成和用于治疗、预防或改善慢性或急性蛋白激酶介导的疾病、紊乱或状况的用途。
• Synthesis and structural investigation of mononuclear penta- and hexa-coordinated Co complexes of 8-hydroxyquinoline derived ligands
  作者：Tanuja Kumari、Ramhari Meena、Lopamudra Giri、Bipul Sarma、Priyanka R. Angarkhe、Jesni M. Jacob、Jagnyaseni Tripathy、Jyoti Joshi、Mahesh Kumar Ravva、Rakesh K. Behera、Swagat K. Mohapatra

  DOI：10.1016/j.molstruc.2022.134253

  日期：2023.2

  This article describes the synthesis and structural property investigation of two new mononuclear Co(II) complexes of 8-hydroxyquinoline derived flexible tridentate N,O,N'- (LI) and tetradentate N,O,O',N'-ligands (LII). The reactions were carried out between CoCl2.6H2O and the respective ligands in methanol to obtain the complexes CoLICl2 and CoLIICl2 in good yields. The complexes are characterized

  本文介绍了 8-羟基喹啉衍生的柔性三齿 N,O,N'- (L I ) 和四齿 N,O,O',N'-配体 ( Ⅱ ）。CoCl 2 .6H 2 O 与相应的配体在甲醇中进行反应，以良好的收率得到络合物 CoL I Cl 2和 CoL II Cl 2。配合物通过元素分析、质谱、红外光谱和单晶 X 射线衍射进行表征。CoL I Cl 2的分子结构显示扭曲的三角双锥配位几何，结构指数参数τ =  0.83。顶端位置被喹啉O-和一个末端Cl-原子占据，而赤道位置被两个N-原子和第二个Cl-原子占据。相比之下，CoL II Cl 2具有略微扭曲的八面体结构，螯合配体 L II的所有供体原子保持赤道位置，两端的 Cl 原子位于顶端位置。电子结构计算用于评估这些配合物的几何、电子和磁性。用于模拟分子的非周期性计算表明强 d π -p πCo与配体之间的键合。两种固态结构的晶体堆积通过喹啉环和 C-H ..
• Preparation, characterization, and catalytic properties of (triphenylphosphine)ruthenium complexes bearing N,O,N′-tridentate ligands
  作者：Hui-Jun Xu、Xiang-Yong Lu、Yi-Zhi Li、Xue-Tai Chen、Zi-Ling Xue

  DOI：10.1016/j.ica.2009.06.055

  日期：2009.10

  Preparation and characterization of (triphenylphosphine)ruthenium complexes bearing N,O,N'-tridentate ligands, [(L-1)RuCl(PPh3)(2)](BF4) (L-1 = 2-[(2-pyridylmethoxy)methyl] pyridine), 1), [(L-2)RuCl(PPh3)(2)](BF4) (L-2 = 8-(2-pyridylmethoxy)quinoline, 2) and [(L-3)RuCl2(PPh3)] (L-3 = 2-[(2-pyridylmethoxy)methyl] quinoline, 3) are described. Complexes 1-3 have been characterized by NMR and elemental analyses. Molecular structures of 2 and 3 have been determined by X-ray crystallography. Both compounds exhibit the octahedral geometry. L-2 adopts the facial configuration in 2 while L-3 is in a mer-arrangement in 3. Complexes 1-3 have proven to be able to catalyze the transfer hydrogenation of several ketones to alcohols in the presence of KOH and 2-propanol at refluxing, among which complex 3 was found to be the most active. (C) 2009 Elsevier B. V. All rights reserved.
• Synthesis, structures and ethylene polymerization activity of chromium(III) complexes with N,O,N′-tridentate ligands
  作者：Fei Chen、Xiang-Yong Lu、Xue-Tai Chen、Hua-Yi Li、You-Liang Hu

  DOI：10.1016/j.ica.2012.02.037

  日期：2012.5

  This paper reports the synthesis and characterization of four neutral chromium(III) complexes bearing N,O,N'-tridentate ligands, [LCrCl3], (L = 2-[(2-pyridylmethoxy)methyl]pyridine, 1; L = 8-(2-pyridylmethoxy) quinoline, 2; L = 8-[(2-pyridylmethoxy)methyl]quinoline, 3; L = 8-(quinolin-8-ylmethoxy)quinoline,4). Molecular structures of 1-3 have been determined by X-ray crystallography, which show that L-1 and L-3 exhibit facial configuration in 1 and 3 while L-2 adopts meridional arrangement in 2. The ethylene polymerization experiments show that complexes 1-4 are moderately active precatalysts for ethylene polymerization with activation with MAO. (C) 2012 Elsevier B.V. All rights reserved.