<(4-Methoxy-2-quinolyl)methyl>formamide | 132833-02-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: <(4-Methoxy-2-quinolyl)methyl>formamide
• 英文别名: 2-formamidomethyl-4-methoxyquinoline；N-[(4-methoxyquinolin-2-yl)methyl]formamide
• CAS: 132833-02-4
• 化学式: C₁₂H₁₂N₂O₂
• 分子量: 216.239
• InChiKey: DEXKSGHKFQNJFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  <(4-Methoxy-2-quinolyl)methyl>formamide 在 TEA 、 三氯氧磷 作用下， 以 二氯甲烷 为溶剂， 反应 0.07h， 以73%的产率得到5-Methoxyimidazo<1,5-a>quinoline
  参考文献：
  名称：

  Langry, Kevin C., Organic Preparations and Procedures International, 1994, vol. 26, # 4, p. 429 - 438

  摘要：

  DOI：
• 作为产物：
  描述：

  甲酸丙酯 、 2-(Aminomethyl)-4-methoxyquinoline dihydrochloride 在 TEA 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以74%的产率得到<(4-Methoxy-2-quinolyl)methyl>formamide
  参考文献：
  名称：

  Langry, Kevin C., Organic Preparations and Procedures International, 1994, vol. 26, # 4, p. 429 - 438

  摘要：

  DOI：

文献信息

• Formation of imidazopyridines by the phase transfer catalyzed reaction of .alpha.-(aminomethyl)pyridines and CHCl3 with alkaline hydroxide
  作者：Kevin C. Langry

  DOI：10.1021/jo00007a028

  日期：1991.3

  The reaction of chloroform with 2-(aminomethyl)pyridine (1) under basic phase-transfer catalysis affords the highly fluorescent imidazo[1,5-alpha]pyridine (2) in 25% isolated yield. Despite the formation of considerable tarry residue, GC-MS indicates that the volatile fraction of the reaction is simple and consists of 2 and two minor residue, GC-MS indicates that the volatile fraction of the reaction is simple and consists of 2 and two minor components identified as N-(2-pyridylmethyl)formamide (6) and (2-pyridylmethyl)isonitrile (7). The basic phase transfer catalyzed reaction of chloroform with a series of alpha-(aminomethyl)azanaphthalenes was found to be general and yield the corresponding annulated imidazo derivaties in comparable yields. Despite product yields in the 25% range, GC of the reaction mixtures indicates that the volatile fractions generally consist of residual starting aminomethyl compound, the imidazo product, and a minor amount of the (alpha-azanaphthylmethyl)formamide. However, 3-(aminomethyl)isoquinoline (18) failed to provide any of the expected imidazo[1,5-b]isoquinoline (19). The failure to detect 19 was investigated.
• LANGRY, KEVIN C., J. ORG. CHEM. , 56,(1991) N, C. 2400-2404
  作者：LANGRY, KEVIN C.

  DOI：——

  日期：——
• Langry Kevin C., Org. Prep. and Proced. Int, 26 (1994) N 4, S 429-438
  作者：Langry Kevin C.

  DOI：——

  日期：——
• Langry, Kevin C., Organic Preparations and Procedures International, 1994, vol. 26, # 4, p. 429 - 438
  作者：Langry, Kevin C.

  DOI：——

  日期：——