3,6-Bis(2-chlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 183483-78-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,6-Bis(2-chlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
• CAS: 183483-78-5
• 化学式: C₁₅H₈Cl₂N₄S
• 分子量: 347.227
• InChiKey: HOOJYWQZVADEMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  硫代卡巴肼 、 2-氯苯甲酸 在 silica-supported dichlorophosphate 作用下， 以 乙醇 为溶剂， 反应 0.13h， 以80%的产率得到3,6-Bis(2-chlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
  参考文献：
  名称：

  Silica-Supported Dichlorophosphate as a Recoverable Cyclodehydrant: Expeditious Synthesis of [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazoles Under Microwave Irradiation

  摘要：

  An expeditious novel approach to 3,6-disubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles using silica-supported dichlorophosphate as a recoverable cyclodehydrant, carboxylic acids and thiocarbohydrazide as starting materials, and microwave irradiation as thermal source was described. The protocol has advantages of concise synthetic step, short time, good yield, easy workup procedure, and no environmental pollution.

  DOI：

  10.1080/00397910902838912

文献信息

• Silica-Supported Dichlorophosphate as a Recoverable Cyclodehydrant: Expeditious Synthesis of [1,2,4]Triazolo[3,4-<i>b</i>][1,3,4]thiadiazoles Under Microwave Irradiation
  作者：Zheng Li、Yanlong Zhao

  DOI：10.1080/00397910902838912

  日期：2009.10.12

  An expeditious novel approach to 3,6-disubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles using silica-supported dichlorophosphate as a recoverable cyclodehydrant, carboxylic acids and thiocarbohydrazide as starting materials, and microwave irradiation as thermal source was described. The protocol has advantages of concise synthetic step, short time, good yield, easy workup procedure, and no environmental pollution.