(2,3-dimethylbutyl)phenylsulfone | 134511-53-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,3-dimethylbutyl)phenylsulfone
• 英文别名: 2,3-dimethylbutylsulfonylbenzene
• CAS: 134511-53-8
• 化学式: C₁₂H₁₈O₂S
• 分子量: 226.34
• InChiKey: ZCIMZXUGGAKDFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2,3-dimethylbutyl)phenylsulfone 在 正丁基锂 、 sodium amalgam 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 乙酸乙酯 为溶剂， 反应 32.5h， 生成 3α,5-cyclo-24-methyl-5α-cholest-22-en-6-one
  参考文献：
  名称：

  Khripach, V. A.; Zhabinskii, V. N.; Ol'khovik, V. K., Journal of Organic Chemistry USSR (English Translation), 1990, vol. 26, # 9.2, p. 1699 - 1706

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-二甲基-1-丁烯 在 吡啶 、 硼烷四氢呋喃络合物 、 双氧水 、 sodium methylate 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 72.67h， 生成 (2,3-dimethylbutyl)phenylsulfone
  参考文献：
  名称：

  Synthesis of secasterol and 24-episecasterol and their toxicity for MCF-7 cells

  摘要：

  The convergent synthesis of biosynthetic precursors of brassinosteroids with a Delta(2)-bond in cycle A-secasterol and 24-episecasterol-was performed. The key stages in the construction of the side chain in these compounds were the Julia olefination of the steroid 22-aldehyde followed by the Sharpless asymmetric dihydroxylation of the intermediate Delta(22)-olefin. The cytotoxicity of the synthesized compounds for breast carcinoma MCF-7 cells was assessed.

  DOI：

  10.1134/s1068162010060117

文献信息

• PYRIDINE-3-CARBOXYAMIDE DERIVATIVE
  申请人：Kitamura Takahiro

  公开号：US20110237590A1

  公开（公告）日：2011-09-29

  To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.

  提供一种新型JAK3抑制剂，可用作器官移植中的预防和/或治疗剂，以及风湿性关节炎、多发性硬化、系统性红斑狼疮、干燥综合征、贝赫切特病、I型糖尿病、自身免疫性甲状腺炎、特发性血小板减少性紫癜、溃疡性结肠炎、克罗恩病、哮喘、过敏性鼻炎、特应性皮炎、接触性皮炎、荨麻疹、湿疹、牛皮癣、过敏性结膜炎、葡萄膜炎、白血病等疾病的预防和治疗。通式（1）所代表的吡啶-3-羧酰胺衍生物： 或其盐或溶剂化合物。
• Synthesis and Growth-Stimulating Activity of 15β-substituted Brassinosteroids
  作者：A. V. Baranovskii、M. P. Popova、V. A. Khripach

  DOI：10.1007/s10600-015-1263-2

  日期：2015.3

  15β-Hydroxybutylcastasterone and its 24-epimer were synthesized from (20S)-15β-(4-benzoyloxybutyl)-20-hydroxymethyl-2α,3α-isopropylidenedioxy-6,6-ethylenedioxy-5α-pregn-16-ene using a sequence of transformations including hydrogenation of the double bond by H2 over Adams’ catalyst, oxidation by Dess–Martin reagent, Julia olefination, Sharpless catalytic dihydroxylation, and hydrolysis of protecting groups. The compounds exhibited activity in growth-stimulating tests that was comparable with those of castasterone and 24-epicastasterone.

  15β-Hydroxybutylcastasterone 及其 24-epimer 由 (20S)-15β-(4-benzoyloxybutyl)-20-hydroxymethyl-2α,3α-isopropylidenedioxy-6 合成、通过一系列转化过程，包括在亚当斯催化剂上用 H2 对双键进行氢化、用 Dess-Martin 试剂进行氧化、Julia 烯化、Sharpless 催化二羟基化以及水解保护基团，生产出了 20-羟甲基-2α,3α-异丙基亚乙二氧基-6,6-亚乙二氧基-5α-孕甾-16-烯。这些化合物在刺激生长试验中表现出的活性与蓖麻甾酮和 24-表蓖麻甾酮相当。
• Intermediates for the synthesis of 19-nor vitamin D compounds
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：EP0516411A1

  公开（公告）日：1992-12-02

  New intermediate compounds that can be used effectively for the synthesis of a broad range of 1α-hydroxy-19-nor-vitamin D compounds. These novel intermediates are characterized by a group selected from hydroxy methyl (-CH₂OH), carboxaldehyde (-CHO), and carboxy ester (-COOAlkyl) at the carbon 22 position of the side chain of a 19-nor-vitamin D nucleus. Intermediates of this type are useful for the introduction of side chain units and thus represent important synthons for the preparation of many different 19-nor-vitamin D compounds.

  可有效用于合成多种 1α-hydroxy-19-nor-vitamin D 化合物的新型中间体化合物。这些新型中间体的特点是在 19-去甲维生素 D 核侧链的碳 22 位置上有一个选自羟基甲基（-CH₂OH）、羧基（-CHO）和羧基酯（-COOAlkyl）的基团。这类中间体可用于引入侧链单元，因此是制备多种不同 19-去甲维生素 D 化合物的重要合成物。
• XRIPACH, V. A.;ZHABINSKIJ, V. N.;OLXOVIK, V. K.;LAXVICH, F. A., ZH. ORGAN. XIMII, 26,(1990) N, S. 1966-1976
  作者：XRIPACH, V. A.、ZHABINSKIJ, V. N.、OLXOVIK, V. K.、LAXVICH, F. A.

  DOI：——

  日期：——
• METHODS FOR PRODUCING PARICALCITOL
  申请人：Azad Pharmaceutical Ingredients AG

  公开号：EP2334640B1

  公开（公告）日：2015-12-23