N-<(benzoyloxy)carbonyl>nortropane | 95799-01-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-<(benzoyloxy)carbonyl>nortropane
• 英文别名: N-(benzyloxycarbonyl)nortropane；Benzyl8-azabicyclo[3.2.1]octane-8-carboxylate；benzyl 8-azabicyclo[3.2.1]octane-8-carboxylate
• CAS: 95799-01-2
• 化学式: C₁₅H₁₉NO₂
• 分子量: 245.321
• InChiKey: VCWRLJUEGMEYTE-UHFFFAOYSA-N

物化性质

• 沸点：
  368.1±21.0 °C(Predicted)
• 密度：
  1.155±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-<(benzoyloxy)carbonyl>nortropane 在 盐酸 、 氢溴酸 作用下， 生成 8-氮杂双环[3.2.1]辛烷盐酸盐
  参考文献：
  名称：

  Synthetic approaches to nortropanes and nortrop-6-enes; intramolecular displacement by nitrogen in 7-membered rings

  摘要：

  The synthesis of simple nortropane and nortrop-6-ene derivatives from cyclohepta-1,3-diene is described. The key intermediates are trans-1-amino-4-chloro-cycloheptanes and -cyclohept-2-enes which are derived efficiently from the corresponding cis-amino-alcohols and undergo intramolecular cyclisation. Corresponding derivatisation of cyclohexa- and cycloocta-1,3-dienes is explored and attempts to achieve Pd-catalysed cyclisation of 1-amino-4-acetoxy-derivatives is described. Nitrogen inversion data for selected nortropane derivatives are included.

  DOI：

  10.1016/s0040-4020(01)80313-6
• 作为产物：
  描述：

  1-氯-1-亚硝基环己烷 在 palladium on activated charcoal 氯化亚砜 、 potassium tert-butylate 、 氢气 、 sodium carbonate 作用下， 以 甲醇 、 四氯化碳 、 六甲基磷酰三胺 、 乙醇 、 氯仿 、 水 、 苯 为溶剂， -10.0~25.0 ℃ 、101.33 kPa 条件下， 反应 107.5h， 生成 N-<(benzoyloxy)carbonyl>nortropane
  参考文献：
  名称：

  A new synthetic route to tropane alkaloids based on [4 + 2] nitroso cycloaddition to 1,3-cycloheptadienes

  摘要：

  DOI：

  10.1021/jo00211a006

文献信息

• [EN] HYDROXY SUBSTITUTED ISOQUINOLINONE DERIVATIVES<br/>[FR] DÉRIVÉS D'ISOQUINOLINONE SUBSTITUÉS PAR UN HYDROXY
  申请人：NOVARTIS AG

  公开号：WO2012175520A1

  公开（公告）日：2012-12-27

  The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

  这项发明涉及以下公式（I）的化合物：如申请中所定义。这些化合物适用于治疗由MDM2和/或MDM4的活性或其变体介导的疾病或疾病。
• HYDROXY SUBSTITUTED ISOQUINOLINONE DERIVATIVES
  申请人：Novartis AG

  公开号：EP2721008A1

  公开（公告）日：2014-04-23
• A new synthetic route to tropane alkaloids based on [4 + 2] nitroso cycloaddition to 1,3-cycloheptadienes
  作者：Hideo Iida、Yohya Watanabe、Chihiro Kibayashi

  DOI：10.1021/jo00211a006

  日期：1985.5
• Synthetic approaches to nortropanes and nortrop-6-enes; intramolecular displacement by nitrogen in 7-membered rings
  作者：Antoinette Naylor (nee Bathgate)、Nicola Howarth、John R. Malpass

  DOI：10.1016/s0040-4020(01)80313-6

  日期：1993.1

  The synthesis of simple nortropane and nortrop-6-ene derivatives from cyclohepta-1,3-diene is described. The key intermediates are trans-1-amino-4-chloro-cycloheptanes and -cyclohept-2-enes which are derived efficiently from the corresponding cis-amino-alcohols and undergo intramolecular cyclisation. Corresponding derivatisation of cyclohexa- and cycloocta-1,3-dienes is explored and attempts to achieve Pd-catalysed cyclisation of 1-amino-4-acetoxy-derivatives is described. Nitrogen inversion data for selected nortropane derivatives are included.