5-methyl-7-nitro-1H-indol-2-carboxylic acid methyl ester | 1120345-02-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-methyl-7-nitro-1H-indol-2-carboxylic acid methyl ester
• 英文别名: 5-methyl-7-nitro-1H-indole-2-carboxylic acid methyl ester；methyl 5-methyl-7-nitro-1H-indole-2-carboxylate
• CAS: 1120345-02-9
• 化学式: C₁₁H₁₀N₂O₄
• 分子量: 234.211
• InChiKey: LPVNQMGIHZNRRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  87.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-methyl-7-nitro-1H-indol-2-carboxylic acid methyl ester 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以47%的产率得到7-Nitro-5-methyl-indol-2-carbonsaeurehydrazid
  参考文献：
  名称：

  INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT

  摘要：

  本发明涉及一种用于保存细胞、组织和器官的组合物，其中包括作为活性成分的式（1）的吲哚和吲唑化合物，或其药用可接受的盐或异构体，对于预防由冷藏、移植手术或移植后再灌注引起的器官、分离的细胞系统或组织的损伤具有有效性；一种保存方法；以及该组合物的制备方法。

  公开号：

  US20100291533A1

文献信息

• INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS
  申请人：Kim Soon Ha

  公开号：US20100210647A1

  公开（公告）日：2010-08-19

  The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

  本发明涉及新的吲哚化合物，其药学上可接受的盐或异构体，用于预防或治疗细胞坏死和坏死相关疾病。本发明还涉及一种预防或治疗细胞坏死和坏死相关疾病的方法和组合物，该组合物包括所述吲哚化合物作为活性成分。
• 세포괴사 저해제로서의 인돌아미드 화합물
  申请人：LG CHEM, LTD. 주식회사 엘지화학(120010134563) Corp. No ▼ 110111-2207995BRN ▼107-81-98139

  公开号：KR20150022707A

  公开（公告）日：2015-03-04

  본 발명은 하기 화학식 (1)의 인돌아미드 화합물, 약제학적으로 허용되는 그의 염 또는 이성체, 및 이를 활성 성분으로 함유함을 특징으로 하는 세포괴사 및 관련 질환을 예방 또는 치료하기 위한 조성물 및 조성물의 제조방법에 관한 것이다. [화학식 1] 상기 식에서 R1, R2, R3, R4 및 R5는 명세서에 정의한 바와 같다. [색인어] 인돌아미드 화합물, 세포괴사, 예방 또는 치료제

  本发明涉及以下化学式（1）的吲哚酰胺化合物，其药学上可接受的盐或同分异构体，并含有其作为活性成分的组合物，用于预防或治疗细胞凋亡和相关疾病的组合物及其制备方法。[化学式 1] 公式中的 R1、R2、R3、R4 和 R5 如规范所定义。[索引词] 吲哚酰胺化合物、细胞凋亡、预防或治疗剂
• [EN] INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS<br/>[FR] COMPOSÉS D'INDOLE EN TANT QU'INHIBITEURS DE NÉCROSE CELLULAIRE
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2009025477A1

  公开（公告）日：2009-02-26

  The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

  本发明涉及新的吲哚化合物、药学上可接受的盐或其异构体，用于预防或治疗细胞坏死和坏死相关疾病。本发明还涉及一种预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包括所述吲哚化合物作为活性成分。
• GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT
  申请人：Kim Soon Ha

  公开号：US20100267708A1

  公开（公告）日：2010-10-21

  The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.

  本发明涉及公式（1）的新化合物，表现出对葡萄糖激酶的优异活性，并且包括该化合物作为活性成分的药物组合物。
• Indole compounds as an inhibitor of cellular necrosis
  申请人：LG Life Sciences Ltd.

  公开号：US08222414B2

  公开（公告）日：2012-07-17

  The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

  本发明涉及新的吲哚化合物，其药学上可接受的盐或异构体，用于预防或治疗细胞坏死和坏死相关疾病。本发明还涉及一种用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包括所述的吲哚化合物作为活性成分。