2-[羟基(二苯基)甲基]丁酸乙酯 | 7142-75-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[羟基(二苯基)甲基]丁酸乙酯
• 英文名称: Ethyl-α-ethyl-β-hydroxy-β.β-diphenylpropionat
• 英文别名: 2-(α-hydroxy-benzhydryl)-butyric acid ethyl ester；2-(α-Hydroxy-benzhydryl)-buttersaeure-aethylester；Ethyl 2-[hydroxy(diphenyl)methyl]butanoate
• CAS: 7142-75-8
• 化学式: C₁₉H₂₂O₃
• 分子量: 298.382
• InChiKey: FRDBLWGQNYXCOQ-UHFFFAOYSA-N

物化性质

• 熔点：
  107-108 °C
• 沸点：
  150 °C(Press: 4 Torr)
• 密度：
  1.104±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[羟基(二苯基)甲基]丁酸乙酯 在 氢氧化钾 、 硫酸 作用下， 生成 2-ethyl-3-phenyl-1H-inden-1-one
  参考文献：
  名称：

  de Fazi, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1916, vol. <5> 25 I, p. 97

  摘要：

  DOI：
• 作为产物：
  描述：

  二苯甲酮 、 丁酸乙酯 在 bromomagnesium diethylamide 作用下， 生成 2-[羟基(二苯基)甲基]丁酸乙酯
  参考文献：
  名称：

  Aldol Type Condensation of Ketones and Esters in the Presence of Diethylaminomagnesium Bromide and Related Compounds¹

  摘要：

  DOI：

  10.1021/ja01144a029

文献信息

• Some 2,3-Disubstituted Indones
  作者：Robert L. Frank、Henning Eklund、John W. Richter、Clinton R. Vanneman、Arnold N. Wennerberg

  DOI：10.1021/ja01229a001

  日期：1944.1
• Berberianu, Chemisches Zentralblatt, 1915, vol. 86, # II, p. 399
  作者：Berberianu

  DOI：——

  日期：——
• de Fazi, Gazzetta Chimica Italiana, 1915, vol. 45 II, p. 148
  作者：de Fazi

  DOI：——

  日期：——
• The role of anesthesiologists in Canadian undergraduate medical education
  作者：Richard Brull、John W. Bradley

  DOI：10.1007/bf03019727

  日期：2001.2

  Purpose: To examine the current role of anesthesiologists in Canadian undergraduate medical education (UME),Methods: A 93-item questionnaire was mailed to the undergraduate course chairs/coordinators for anesthesia at the 16 medical schools in Canada.Results: Of the faculty anesthesiologists in Canada, 1.7%, 4.9%, and 4.9% teach pre-clerkship lectures, seminars, and PBL tutorials, respectively Annually, anesthesiologists teach an average of 3.3 hr (range: 0 to 15) of pre-clerkship lectures and 12.8 hr (range: 0 to 48) of pre-clerkship seminars at each medical school, The topics most commonly taught by anesthesiologists in pre-clerkship lectures and seminar; are pharmacology and perioperative patient assessment, respectively An anesthesia rotation during clerkship is mandatory at 13 schools, with an average duration of 9.6 dy (range: 5 - 20 dy), Clerkship teaching methods vary: ten schools provide seminars, eight use videos, six use computers, six use an airway skills laboratory, and four use an anesthesia simulator. The most common topics taught in clerkship anesthesia seminars are airway management and fluid therapy.Conclusion: A very small proportion of faculty anesthesiologists participate in Canadian UME at the pre-clerk ship level. Considerable variation exists in the amount and format of teaching by anesthesiologists among the Canadian undergraduate curricula, particularly at the pre-clerkship level. However, our results indicate that anesthesiologists are assuming a more important teaching role during clerkship. Our findings may suggest that Canadian medical schools are overlooking the advantages that anesthesiologists offer to UME at the pre-clerkship level. or that many anesthesiologists are reluctant to assume pre-clerkship teaching responsibilities.
• Aldol Type Condensation of Ketones and Esters in the Presence of Diethylaminomagnesium Bromide and Related Compounds¹
  作者：Keiiti Sisido、Hitosi Nozaki、Osamu Kurihara

  DOI：10.1021/ja01144a029

  日期：1952.12