2-allyl-2-(methoxycarbonyl)pent-4-enoic acid | 526224-08-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-allyl-2-(methoxycarbonyl)pent-4-enoic acid
• 英文别名: 2-Methoxycarbonyl-2-prop-2-enylpent-4-enoic acid；2-methoxycarbonyl-2-prop-2-enylpent-4-enoic acid
• CAS: 526224-08-8
• 化学式: C₁₀H₁₄O₄
• 分子量: 198.219
• InChiKey: BPRRAAKTZJOYFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-allyl-2-(methoxycarbonyl)pent-4-enoic acid 在 Hoveyda-Grubbs catalyst second generation 、 N,N-二异丙基乙胺 作用下， 以 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.5h， 生成
  参考文献：
  名称：

  串联闭环复分解/转移加氢：烯烃的实际化学选择性加氢

  摘要：

  提出了使用钌复分解催化剂的烯烃的操作简单的化学选择性转移氢化。实用性很强，可以将转移氢化试剂直接添加到复分解反应中，并在室温下在一个罐中对产物烯烃进行氢化，而无需密封容器以防止氢气逸出。还原适用于各种烯烃，并且可以在芳基卤化物和苄基存在下进行，这是钯催化氢化的显着缺点。介绍了范围和机械方面的考虑。

  DOI：

  10.1021/ol5019739
• 作为产物：
  描述：

  二烯丙基丙二酸二甲酯 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以48%的产率得到2-allyl-2-(methoxycarbonyl)pent-4-enoic acid
  参考文献：
  名称：

  Sulfur-mediated radical cyclisation reactions on solid support

  摘要：

  Two methods for effecting radical cyclisation reactions of solid-supported 1,6-dienes are described. Additions of thiophenol and p-tolyl benzeneselenosulfonate have each been achieved with a concomitant 5-exo-trig radical cyclisation leading to the formation of highly functionalised cyclopentanes. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02594-7

文献信息

• N-Heterocyclic carbene–gold(I)-catalyzed carboheterofunctionalization of alkenes with arylboronic acids
  作者：Shifa Zhu、Lijuan Ye、Wanqing Wu、Huanfeng Jiang

  DOI：10.1016/j.tet.2013.09.097

  日期：2013.12

  A new approach to the synthesis of pyrrolidine, tetrahydrofuran, and imidazolidin-2-one via N-heterocyclic carbene–gold(I)-catalyzed intramolecular amino- or oxyarylation reactions from a wide variety of alkene substrates such as N-allyl amides, alcohols, carboxylic acids, and ureas in the presence of Selectfluor under mild conditions has been developed.

  通过一种新方法吡咯烷，四氢呋喃，和咪唑烷-2-酮的合成Ñ -杂环卡宾-金（I）催化的分子内的氨基或oxyarylation从各种各样的烯烃底物如反应的ñ -烯丙基酰胺，醇已经开发出在温和条件下在Selectfluor的存在下制备羧酸，羧酸和脲的方法。
• [EN] AZETIDINONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A METHOD FOR PRODUCING 1- beta -ALKYL AZETIDINONE USING THE SAME<br/>[FR] DERIVES AZETODINONE, PROCEDE DE PREPARATION DE CEUX-CI ET PROCEDE DE PRODUCTION DE 1- beta -ALKYLE AZETODINONE AU MOYEN DESDITS DERIVES
  申请人：DAE WOONG PHARMA

  公开号：WO2001072704A1

  公开（公告）日：2001-10-04

  The present invention relates to new azetidinone derivatives represented formula 2, synthetic process of that, and synthetic process of 1-β-alkyl azetidinone using that. According to the present invention, 1-β-alkyl azetidinone is synthesized only with a general base and reactant in high yield using new azetidinone derivatives without any additional protecting group.
• Tandem Ring-Closing Metathesis/Transfer Hydrogenation: Practical Chemoselective Hydrogenation of Alkenes
  作者：Timothy Connolly、Zhongyu Wang、Michael A. Walker、Ivar M. McDonald、Kevin M. Peese

  DOI：10.1021/ol5019739

  日期：2014.9.5

  chemoselective transfer hydrogenation of alkenes using ruthenium metathesis catalysts is presented. Of great practicality, the transfer hydrogenation reagents can be added directly to a metathesis reaction and effect hydrogenation of the product alkene in a single pot at ambient temperature without the need to seal the vessel to prevent hydrogen gas escape. The reduction is applicable to a range of alkenes and

  提出了使用钌复分解催化剂的烯烃的操作简单的化学选择性转移氢化。实用性很强，可以将转移氢化试剂直接添加到复分解反应中，并在室温下在一个罐中对产物烯烃进行氢化，而无需密封容器以防止氢气逸出。还原适用于各种烯烃，并且可以在芳基卤化物和苄基存在下进行，这是钯催化氢化的显着缺点。介绍了范围和机械方面的考虑。
• Sulfur-mediated radical cyclisation reactions on solid support
  作者：David C Harrowven、Peter J May、Mark Bradley

  DOI：10.1016/s0040-4039(02)02594-7

  日期：2003.1

  Two methods for effecting radical cyclisation reactions of solid-supported 1,6-dienes are described. Additions of thiophenol and p-tolyl benzeneselenosulfonate have each been achieved with a concomitant 5-exo-trig radical cyclisation leading to the formation of highly functionalised cyclopentanes. (C) 2002 Elsevier Science Ltd. All rights reserved.