2-(2-aminoethoxy)ethanol hydrochloride | 40321-53-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-aminoethoxy)ethanol hydrochloride
• 英文别名: 2-(2-aminoethoxy)ethanol;hydrochloride
• CAS: 40321-53-7
• 化学式: C₄H₁₁NO₂*ClH
• 分子量: 141.598
• InChiKey: FWEDZEJNGZTGFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.62
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-aminoethoxy)ethanol hydrochloride 、 十八烷酰氯 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 16.0h， 以40%的产率得到octadecanoic acid 2-(2-aminoethoxy)ethyl ester hydrochloride
  参考文献：
  名称：

  Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents

  摘要：

  替代聚羧酸配体分子及其相应的金属配合物，最好是具有顺磁金属配合物，用于在磁共振成像（MRI）领域中产生响应。这些聚羧酸配体的顺磁配合物具有有利的表面活性性质，并且在用于研究血液池的配方中作为MRI对比介质非常有用。

  公开号：

  US06342598B1
• 作为产物：
  描述：

  二甘醇胺 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 0.5h， 生成 2-(2-aminoethoxy)ethanol hydrochloride
  参考文献：
  名称：

  Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents

  摘要：

  替代聚羧酸配体分子及其相应的金属配合物，最好是具有顺磁金属配合物，用于在磁共振成像（MRI）领域中产生响应。这些聚羧酸配体的顺磁配合物具有有利的表面活性性质，并且在用于研究血液池的配方中作为MRI对比介质非常有用。

  公开号：

  US06342598B1

文献信息

• Novel ester isocyanates
  申请人：Rohm and Haas Company

  公开号：US04088674A1

  公开（公告）日：1978-05-09

  This invention concerns novel ester isocyanates derived from acyloxyalkylamine hydrochlorides. The novel compounds may contain a hetero atom in either the acid or alkanolamine moiety and may contain oxalic acid as the acyl moiety.

  这项发明涉及从酰氧基烷胺盐酸盐衍生的新型酯异氰酸酯。这些新型化合物可能在酸或烷基胺部分含有杂原子，并且可能含有草酸作为酰基。
• New antitumor agents containing the anthracene nucleus
  作者：Timothy P. Wunz、Robert T. Dorr、David S. Alberts、Cynthia L. Tunget、Janine Einspahr、Sharlene Milton、William A. Remers

  DOI：10.1021/jm00391a009

  日期：1987.8

  variety of human tumor cell lines, fresh human tumors, and P-388 leukemia. Those most closely related to bisantrene were less active than it was, but a subset of compounds with saturated side chains containing two basic nitrogens showed good activity. Two compounds of this subset, N,N'-bis[2-(dimethylamino)ethyl]-9,10-anthracenebis(methylamine)(6 ), and N,N'-bis(1-ethyl-3-piperidinyl)-9,10-anthracenebis(methylamine)(19

  合成了21种与比索汀有关的新化合物，并通过针对各种人类肿瘤细胞系，新鲜人类肿瘤和P-388白血病的克隆形成测定法进行了体外测试。与bisantrene最密切相关的那些化合物的活性低于其活性，但是具有饱和侧链的含两个碱性氮的化合物子集显示出良好的活性。此子集的两个化合物，N，N'-双[2-（二甲基氨基）乙基] -9,10-蒽双（甲胺）（6）和N，N'-双（1-乙基-3-哌啶基）- 9,10-蒽二（甲胺）（19）在体外对人肿瘤细胞系非常活跃，但对新鲜的人肿瘤或P-388白血病细胞没有活性。它们在小鼠肿瘤模型中仅具有边缘活性。从而，对于体内这些蒽化合物在体内对抗小鼠肿瘤的活性，新鲜的人类肿瘤和体外P-388白血病细胞比已建立的细胞系更好地预测。在作用方式方面，这些化合物似乎与比桑蒽不同。例如，6在细胞毒性药物浓度下不会引起大分子合成的抑制和DNA单链断裂的促进。毒理学研究表明，快速给药引起急性神
• Synthesis and anticonvulsant and sedative-hypnotic activity of 4-(alkylimino)-2,3-dihydro-4H-1-benzopyrans and benzothiopyrans
  作者：Anna Arnoldi、Alberto Bonsignori、Piero Melloni、Lucio Merlini、Maria Luisa Quadri、Alessandro C. Rossi、Mariella Valsecchi

  DOI：10.1021/jm00172a030

  日期：1990.10

  A series of 4-(alkylimino)-5-hydroxy-7-alkyl-2,3-dihydro-4H-1-benzopyrans and -thiopyrans were synthesized and evaluated for anticonvulsant activity. Preliminary screening of these compounds revealed that 2,2-dimethyl-4-[(2-hydroxyalkyl)imino]-5-hydroxy-7-pentyl-2,3- dihydro-4H-1-benzopyrans 19 and 29, the 7-butyl analogue 34, and the corresponding 7-pentyl-4H-1-benzothiopyrans 38 and 39 had the most promising anticonvulsant activity. Synthesis of both enantiomers of 29 and 39 indicated that the R isomers 30 and 40 were the most active and showed very good protection against MES, pentylenetetrazole, and mercaptopropionic acid induced seizures after oral administration in mice. In the Irwin test these compounds showed a generalized depressant activity but at dosages higher than those showing anticonvulsant activity, whereas acute toxicity after oral administration was low (LD50 higher than 400 mg/kg).
• Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor
  作者：Lawrence J. MacPherson、Erol K. Bayburt、Michael P. Capparelli、Regine S. Bohacek、Frank H. Clarke、Rajendra D. Ghai、Yumi Sakane、Carol J. Berry、Jane V. Peppard、Angelo J. Trapani

  DOI：10.1021/jm00076a009

  日期：1993.11

  A potent macrocyclic inhibitor of neutral endopeptidase (NEP) 24.11 was designed using a computer model of the active site of thermolysin. This 10-membered ring lactam represents a general mimic for any hydrophobic dipeptide in which the two amino acid side chains bind to an enzyme in a contiguous orientation. The parent 10-membered ring lactam was synthesized and exhibited excellent potency as an NEP 24.11 inhibitor (IC50 = 3 nM). In order to improve oral bioavailability, various functionality was attached to the macrocycle. These modifications lead to CGS 25155, an orally active NEP 24.11 inhibitor that slows down the degradation of the cardiac hormone atrial natriuretic factor, producing a lowering of blood pressure in the DOCA-salt rat model of hypertension.
• Gaviraghi; Nicola; Pinza, Farmaco, Edizione Scientifica, 1980, vol. 35, # 10, p. 801 - 811
  作者：Gaviraghi、Nicola、Pinza、Pifferi

  DOI：——

  日期：——