2-丙醇,1-氯-3-(二乙胺基)- | 15285-59-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 中文名称: 2-丙醇,1-氯-3-(二乙胺基)-
• 英文名称: 1-chloro-3-diethylaminopropan-2-ol
• 英文别名: 1-chloro-3-diethylamino-propan-2-ol；1-chloro-3-diethylamino-2-propanol；1-Chlor-3-diaethylamino-propan-2-ol；β'-Chlor-β-diaethylamino-isopropylalkohol；Diaethyl-(3-chlor-2-hydroxy-propyl)-amin；N,N-diethyl-2-hydroxy-3-chloropropanamine；1-chloro-3-(diethylamino)propan-2-ol
• CAS: 15285-59-3
• 化学式: C₇H₁₆ClNO
• 分子量: 165.663
• InChiKey: INWIZUCMCGANRE-UHFFFAOYSA-N

物化性质

• 熔点：
  1-3 °C
• 沸点：
  83-85 °C(Press: 3 Torr)
• 密度：
  1.0080 g/cm3(Temp: 21 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-丙醇,1-氯-3-(二乙胺基)- 在 sodium hydroxide 、 氨 作用下， 生成 1-(2-amino-4,5-dimethyl-anilino)-3-diethylamino-propan-2-ol
  参考文献：
  名称：

  Heterocyclic Basic Compounds. VII. Basically-substituted Isoalloxazine Derivatives¹

  摘要：

  DOI：

  10.1021/ja01209a055
• 作为产物：
  描述：

  1,1’-diethyl-3-hydroxyazetidinium chloride 生成 2-丙醇,1-氯-3-(二乙胺基)-
  参考文献：
  名称：

  Ring-opening alkylations of 1,5-dialkyl-3-substituted azetidinium cations. Substituent entropy-controlled strained ring-chain equilibria

  摘要：

  DOI：

  10.1021/jo01266a010

文献信息

• The Investigation of the Alkylation Reactions of Hydroxy and En‐Oximes with Some Halohydrins and Epoxides
  作者：Sultan Kurbanlı、Nejdet Şen、Ersin Güler、Ahmet Koçak

  DOI：10.1081/scc-120030754

  日期：2004.12.31

  Abstract Suitable glycol ethers (3a–d, 4a–d) and halohydrine compounds (11a–c) were synthesized in good yield by the alkylation reactions of the oximes, having hydroxy and double bond in its structure, with mono‐ and dihalogenhydrines in the medium of basic and solid–liquid phase transfer catalyst. A series of aminoalcohols were synthesized from these compounds obtained (16a, 17b, 18b).

  摘要 通过结构中具有羟基和双键的肟的烷基化反应，以良好的收率合成了合适的二醇醚（3a-d，4a-d）和卤代醇化合物（11a-c）和单卤代醇和二卤代醇。碱性介质和固液相转移催化剂。由这些获得的化合物合成了一系列氨基醇（16a、17b、18b）。
• Treatment of acute myeloid leukemia with indolinone compounds
  申请人：SUGEN, Inc.

  公开号：US20030130280A1

  公开（公告）日：2003-07-10

  A method of treating acute myeloid leukemia in patient positive for FLT-3-ITD is described. The treatment is accomplished by administration of a compound of Formula I or II as defined herein.

  描述了一种治疗FLT-3-ITD阳性患者急性髓系白血病的方法。该治疗通过给予本文中定义的I或II式化合物来实现。
• Treatment of excessive osteolysis with indolinone compounds
  申请人：SUGEN, INC.

  公开号：US20040209937A1

  公开（公告）日：2004-10-21

  Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.

  本文描述的式I和式II的化合物可用于治疗过度骨溶解，通过抑制M-CSF介导的破骨细胞发育。这些化合物还可用于抑制CSF1R的磷酸化，并用于治疗表达CSF1R的癌症。
• 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as portein kinase inhibitors
  申请人：SUGEN, INC.

  公开号：US20030092917A1

  公开（公告）日：2003-05-15

  The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

  本发明涉及吡咯替代的2-吲哚酮化合物及其药用可接受的盐，这些化合物可以调节蛋白激酶的活性，因此预计在预防和治疗蛋白激酶相关的细胞疾病，如癌症方面具有用处。
• Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
  申请人：——

  公开号：US20020032204A1

  公开（公告）日：2002-03-14

  The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

  本发明涉及调节蛋白激酶（“PKs”）活性的某些3-(吡咯-2-基甲基亚甲基)-2-吲哚酮衍生物的Mannich碱前药。还公开了包含这些化合物的药物组合物、利用包含这些化合物的药物组合物治疗与异常PK活性相关的疾病的方法以及制备它们的方法。