N-(3-methoxybenzoyl)leucine | 1379548-55-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(3-methoxybenzoyl)leucine
• 英文别名: 2-[(3-methoxybenzoyl)amino]-4-methylpentanoic acid
• CAS: 1379548-55-6
• 化学式: C₁₄H₁₉NO₄
• mdl: MFCD09047830
• 分子量: 265.309
• InChiKey: MUMMHDPLNMLLKB-UHFFFAOYSA-N

物化性质

• 沸点：
  455.4±30.0 °C(Predicted)
• 密度：
  1.145±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(3-methoxybenzoyl)leucine 、 二乙胺 在 N,N'-二异丙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以35%的产率得到N-(3-methoxybenzoyl)leucine diethylamide
  参考文献：
  名称：

  A Simple Chiral Recognition System to Investigate Substituent Effects on π–π Interactions

  摘要：

  We have used a simple molecular recognition system to study substituent effects in aromatic interactions. A series of substituted benzoylleucine diethyl amides with aromatic rings of varying electronic character were crystallized. All of the substituted dimers organized into homochiral dimers in the solid state but with pronounced differences in regard to the orientation of the aromatic rings with respect to each other. However, no homochiral dimerization was observed in the unsubstituted case.

  DOI：

  10.1021/ol3014057
• 作为产物：
  描述：

  间甲氧基苯甲酰氯 、 DL-亮氨酸 在 methyloxirane 作用下， 以 四氢呋喃 为溶剂， 以81%的产率得到N-(3-methoxybenzoyl)leucine
  参考文献：
  名称：

  A Simple Chiral Recognition System to Investigate Substituent Effects on π–π Interactions

  摘要：

  We have used a simple molecular recognition system to study substituent effects in aromatic interactions. A series of substituted benzoylleucine diethyl amides with aromatic rings of varying electronic character were crystallized. All of the substituted dimers organized into homochiral dimers in the solid state but with pronounced differences in regard to the orientation of the aromatic rings with respect to each other. However, no homochiral dimerization was observed in the unsubstituted case.

  DOI：

  10.1021/ol3014057

文献信息

• A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS.
  申请人：Insusense ApS

  公开号：EP3981394A1

  公开（公告）日：2022-04-13

  The present invention relates to the use of sortilin antagonists, in particular compounds of Formula (I), (II), (III), and (IV), in the treatment or prevention of hearing loss. Also provided are pharmaceutical compositions comprising the sortilin antagonists herein disclosed and methods for the treatment or prevention of hearing loss in a subject in need thereof.

  本发明涉及索西林拮抗剂，特别是式(I)、(II)、(III)和(IV)化合物在治疗或预防听力损失中的用途。本发明还提供了包含本发明公开的索替林拮抗剂的药物组合物，以及治疗或预防有需要的受试者听力损失的方法。