phenethyl 2-phenyl-4-quinolone-6-carboxylate | 90033-88-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: phenethyl 2-phenyl-4-quinolone-6-carboxylate
• 英文别名: 2-phenylethyl 4-oxo-2-phenyl-1H-quinoline-6-carboxylate
• CAS: 90033-88-8
• 化学式: C₂₄H₁₉NO₃
• 分子量: 369.42
• InChiKey: UBOIFRIHRJTFJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氧代-2-苯基-1H-喹啉-6-羧酸 生成 phenethyl 2-phenyl-4-quinolone-6-carboxylate
  参考文献：
  名称：

  ENOMOTO, HIROSHI;NOMURA, TADATOSHI;AOYAGI, YOSHIAKI;CHOKAI, SHOICHI;FUJIT+

  摘要：

  DOI：

文献信息

• 4-quinolone derivatives having anti-inflammatory, anti-allergic,
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：US04711898A1

  公开（公告）日：1987-12-08

  4-Quinolone derivatives of the present invention are useful for their anti-inflammatory, anti-allergenic, antitussive, expectorant and antithrombotic activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.

  本发明的4-喹诺酮衍生物具有抗炎、抗过敏、止咳、祛痰和抗血栓活性。本文描述了含有这些化合物和其药学上可接受的盐的药物组合物以及治疗人类和动物的方法。
• 4-Quinolone derivatives
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0104959A1

  公开（公告）日：1984-04-04

  The present invention relates to 4-quinolone derivatives represented by the following general formula (I) and salts thereof, as well as their use as pharmaceuticals and methods for manufacturing them. In the formula, R' and R2 are same or different and they are hydrogen, lower aklyl of one to eight carbon chain length or lower alkenyl of one to four carbon chain length; R3 stands for hydrogen, lower alkyl of one to eight carbon chain length, lower alkyl of one to eight carbon chain length with one or two hydroxyl group(s), lower alkyl or three to ten carbon chain length with one or two ether bond(s), or-(CH2)nA where n is an integer of 1 to 3 and A is acetyl, acetyloxy, cyano orphenoxy; Z stands for phenyl with or without substituent(s) selected from a group consisting of hydrogen, halogen, lower alkyl of one to eight carbon chain length, lower haloalkyl of one to three carbon chain length, lower alkoxy of one to four carbon chain length and COOR4 (in which R4 is hydrogen or lower alkyl of one to four carbon chain length) or Z stands for unsaturated hetero ring radical with five or six members having nitrogen, oxygen or sulfur as hetero atom.

  本发明涉及以下通式(I)代表的4-喹啉酮衍生物及其盐，以及它们作为药物的用途和制造方法。 式中，R'和 R2 可相同或不同，它们分别为氢、1 至 8 个碳链长度的低级烷基或 1 至 4 个碳链长度的低级烯基；R3 代表氢、1 至 8 个碳链长度的低级烷基、1 至 8 个碳链长度的低级烷基且带有 1 或 2 个羟基、3 至 10 个碳链长度的低级烷基且带有 1 或 2 个醚键，或-(CH2)nA，其中 n 为 1 至 3 的整数，A 为乙酰基、乙酰氧基、氰基或苯氧基；Z 代表苯基，带有或不带有选自氢、卤素、1 至 8 个碳链长度的低级烷基、1 至 3 个碳链长度的低级卤代烷基、1 至 4 个碳链长度的低级烷氧基和 COOR4（其中 R4 为氢或 1 至 4 个碳链长度的低级烷基）的取代基，或 Z 代表不饱和杂环基，其五个或六个成员的杂原子为氮、氧或硫。
• ENOMOTO, HIROSHI;NOMURA, TADATOSHI;AOYAGI, YOSHIAKI;CHOKAI, SHOICHI;FUJIT+
  作者：ENOMOTO, HIROSHI、NOMURA, TADATOSHI、AOYAGI, YOSHIAKI、CHOKAI, SHOICHI、FUJIT+

  DOI：——

  日期：——
• US4711898A
  申请人：——

  公开号：US4711898A

  公开（公告）日：1987-12-08