Dimethyl 4-(3-aminonaphthalen-2-yl)oxybenzene-1,2-dicarboxylate | 640295-90-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Dimethyl 4-(3-aminonaphthalen-2-yl)oxybenzene-1,2-dicarboxylate
• 英文别名: dimethyl 4-(3-aminonaphthalen-2-yl)oxybenzene-1,2-dicarboxylate
• CAS: 640295-90-5
• 化学式: C₂₀H₁₇NO₅
• 分子量: 351.359
• InChiKey: JTSBZMVOCFJPIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  87.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Dimethyl 4-(3-aminonaphthalen-2-yl)oxybenzene-1,2-dicarboxylate 在 三甲基苯基硅烷 、 碘 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 4-{3-[(4-Chloro-pyridine-2-carbonyl)-amino]-naphthalen-2-yloxy}-phthalic acid
  参考文献：
  名称：

  A new class of glycogen phosphorylase inhibitors

  摘要：

  A new class of diacid analogues that binds at the AMP site not only are very potent but have similar to 10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay. The synthesis, structure, and in vitro and in vivo biological evaluation of these liver selective glycogen phosphorylase inhibitors are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.08.046
• 作为产物：
  描述：

  4-硝基邻苯二甲酸二甲酯 、 3-氨基-2-萘酚 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 Dimethyl 4-(3-aminonaphthalen-2-yl)oxybenzene-1,2-dicarboxylate
  参考文献：
  名称：

  A new class of glycogen phosphorylase inhibitors

  摘要：

  A new class of diacid analogues that binds at the AMP site not only are very potent but have similar to 10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay. The synthesis, structure, and in vitro and in vivo biological evaluation of these liver selective glycogen phosphorylase inhibitors are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.08.046

文献信息

• A new class of glycogen phosphorylase inhibitors
  作者：Zhijian Lu、Joann Bohn、Raynald Bergeron、Qiaolin Deng、Kenneth P. Ellsworth、Wayne M. Geissler、Georgianna Harris、Peggy E. McCann、Brian McKeever、Robert W. Myers、Richard Saperstein、Christopher A. Willoughby、Jun Yao、Kevin Chapman

  DOI：10.1016/j.bmcl.2003.08.046

  日期：2003.11

  A new class of diacid analogues that binds at the AMP site not only are very potent but have similar to 10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay. The synthesis, structure, and in vitro and in vivo biological evaluation of these liver selective glycogen phosphorylase inhibitors are discussed. (C) 2003 Elsevier Ltd. All rights reserved.