5-amino-2-methyl-1,2-dihydropyrazol-3-one | 74530-10-2

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 5-amino-2-methyl-1,2-dihydropyrazol-3-one
• 英文别名: 5-Amino-2-methyl-1,2-dihydro-pyrazol-3-on；3-amino-1-methyl-1H-pyrazol-5-ol；5-amino-2-methyl-1H-pyrazol-3-one
• CAS: 74530-10-2
• 化学式: C₄H₇N₃O
• mdl: MFCD18909318
• 分子量: 113.119
• InChiKey: YGVFIVSNVVUSCS-UHFFFAOYSA-N

物化性质

• 沸点：
  185.2±43.0 °C(Predicted)
• 密度：
  1.240±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-amino-2-methyl-1,2-dihydropyrazol-3-one 、 六氟乙酰丙酮 在 溶剂黄146 作用下， 反应 2.0h， 以86%的产率得到2-methyl-4,6-bis(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3(2H)-one
  参考文献：
  名称：

  带有1 H-吡唑并[3,4- b ]吡啶3-3 （2 H）-one核心的Deazapurine类似物：合成和生物活性

  摘要：

  为氟化和非氟化的1的合成的新方法ħ -吡唑并[3,4- b ]吡啶-3-酮被开发。反应是通过将富含电子的3-氨基-1 H-吡唑-5（4 H）-1与1,3-二酮环化而进行的，所获得的产物具有良好的产率和极好的区域选择性。该产品可被视为脱氮嘌呤类似物，已测试了碱性磷酸酶（h- TNAP和h- IAP）和核苷酸焦磷酸酶/磷酸二酯酶（h- NPP1和h‐NPP3）抑制曲线。大多数衍生物对组织非特异性和肠道碱性磷酸酶和核苷酸焦磷酸酶（NPP1和NPP3）酶表现出选择性和有效的抑制作用。通过分子对接分析研究了最有效抑制剂的可能结合方式。

  DOI：

  10.1002/ejoc.201800163
• 作为产物：
  描述：

  氰乙酸乙酯 、 甲基肼 生成 5-amino-1-methyl-1,2-dihydropyrazol-3-one 、 5-amino-2-methyl-1,2-dihydropyrazol-3-one
  参考文献：
  名称：

  Synthesis of 2-Aminonicotinamides by Raney Nickel Cleavage of Pyrazolo[3,4-b]-pyridines¹

  摘要：

  DOI：

  10.1021/ja01519a043

文献信息

• Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
  申请人：——

  公开号：US20020007059A1

  公开（公告）日：2002-01-17

  Compounds of formula I 1 are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

  公式I的化合物在治疗由钾通道开放剂预防或改善的疾病中很有用。还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
• Synthesis of glycosides of 1H-Pyrazolo[3,4-b]pyridin-3(2H)-ones
  作者：Linda Supe、Martin Hein、Viktor O. Iaroshenko、Alexander Villinger、Peter Langer

  DOI：10.1016/j.tet.2020.131522

  日期：2020.10

  A number of new fluorinated and non-fluorinated glycosides of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were synthesized by direct attachment of the carbohydrate moiety to the heterocycle using the silyl Hilbert-Jones glycosylation method. The products were obtained in good to excellent yields and with very good anomeric stereoselectivity. The starting 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were prepared

  通过使用甲硅烷基希尔伯特-琼斯糖基化将碳水化合物部分直接连接到杂环上，合成了许多1 H-吡唑并[3,4- b ]吡啶3（2 H）-的新的氟化和非氟化糖苷方法。获得的产物具有良好的产率至优异的产率以及非常好的异头立体选择性。起始的1 H-吡唑并[3,4- b ]吡啶-3（2 H）-是通过1，3-二羰基化合物与含有烯胺官能团的富电子杂环的区域选择性环化制备的。
• 3-(Dichloroacetyl)chromone; A New Building Block for the Synthesis of Formylated Purine Isosteres: Design and Synthesis of Fused α-(Formyl)pyridines
  作者：Viktor Iaroshenko、Peter Langer、Satenik Mkrtchyan、Gagik Ghazaryan、Ani Hakobyan、Aneela Maalik、Linda Supe、Alexander Villinger、Andrei Tolmachev、Dmytro Ostrovskyi、Vyacheslav Sosnovskikh、Tariel Ghochikyan

  DOI：10.1055/s-0030-1258364

  日期：2011.2

  The first synthesis of 3-(dichloroacetyl)chromone from 3-(dimethylamino)-1-(2-hydroxyphenyl)propen-1-one and dichloroacetyl chloride is described. The reaction of electron-rich aminoheterocycles with 3-(dichloroacetyl)chromone provides a set of diverse fused pyridines bearing the CHCl2-substituent at the α-position of the pyridine core. Subsequent hydrolysis leads to the formation of annulated α-(formyl)pyridines

  描述了由3-（二甲基氨基）-1-（2-羟基苯基）丙烯-1-酮和二氯乙酰氯首次合成3-（二氯乙酰基）色酮。富电子的氨基杂环与3-（二氯乙酰基）色酮的反应提供了一组不同的稠合吡啶，其在吡啶核的α-位带有CHCl 2-取代基。随后的水解导致环状的α-（甲酰基）吡啶的形成。 3-（二氯乙酰基）色酮-4 H -1-苯并吡喃-4-酮-杂环胺-稠合吡啶-环化反应
• 3-Methoxalylchromone—a novel versatile reagent for the regioselective purine isostere synthesis
  作者：Satenik Mkrtchyan、Viktor O. Iaroshenko、Sergii Dudkin、Ashot Gevorgyan、Marcelo Vilches-Herrera、Gagik Ghazaryan、Dmitriy M. Volochnyuk、Dmytro Ostrovskyi、Zeeshan Ahmed、Alexander Villinger、Vyacheslav Ya. Sosnovskikh、Peter Langer

  DOI：10.1039/c0ob00379d

  日期：——

  The first synthesis of 3-methoxalylchromone was described. The reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated pyridines bearing a CO2Me substituent located at the α-position of the pyridine core.

  首次描述了 3-甲氧基苯丙酮的合成。后者与富含电子的氨基杂环反应后，得到了一组杂环吡啶，其吡啶核心的δ位上带有 CO2Me 取代基。
• Structure–activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as KATP channel openers
  作者：Irene Drizin、Robert J. Altenbach、Steven A. Buckner、Kristi L. Whiteaker、Victoria E. Scott、John F. Darbyshire、Venkata Jayanti、Rodger F. Henry、Michael J. Coghlan、Murali Gopalakrishnan、William A. Carroll

  DOI：10.1016/j.bmc.2004.01.038

  日期：2004.4

  In search of a novel chemotype of KATP channel openers a series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones was synthesized. It was found that cyclopentanone in the left hand portion of the molecule was 4-fold more potent than cyclohexanone. Introduction of gem-dimethyl groups as well as incorporation of oxygen in the cyclohexanone ring in the left hand portion of the molecule increased the potency 10-fold. In the right hand portion of the molecule, the NH-group of the pyrazolone can be effectively substituted by oxygen increasing the activity 5-fold. Incorporation of a methyl group adjacent to the dihydropyridine (DHP) nitrogen not only significantly boosted activity, but also provided an additional benefit of increased metabolic stability. In vitro tests on the tissue from pig bladder strips provided further confirmation of K-ATP activity of these compounds. (C) 2004 Elsevier Ltd. All rights reserved.