2-乙氧基-3-丁烯-1-醇 - CAS号 34684-08-7

计算性质

辛醇/水分配系数(LogP)：

0.4
重原子数：

8
可旋转键数：

4
环数：

0.0
sp3杂化的碳原子比例：

0.666
拓扑面积：

29.5
氢给体数：

1
氢受体数：

2

安全信息

海关编码：

2909499000

SDS

SDS：e03e8a39b53bb223e106dce4e844cb49

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Name:	2-Ethoxy-3-Buten-1-ol Material Safety Data Sheet
Synonym:	None
CAS:	34684-08-7

Section 1 - Chemical Product MSDS Name:2-Ethoxy-3-Buten-1-ol Material Safety Data Sheet
Synonym:None

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
34684-08-7	2-Ethoxy-3-Buten-ol	ca 100	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. The toxicological properties of this material have not been fully investigated.
Skin:
May cause skin irritation. The toxicological properties of this material have not been fully investigated.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 34684-08-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Not available.
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H12O2
Molecular Weight: 116.16

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 34684-08-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-Ethoxy-3-Buten-ol - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 34684-08-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 34684-08-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 34684-08-7 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

作为反应物：

描述：

2-乙氧基-3-丁烯-1-醇在甲醇、 2,2-二羟甲基丙酸、三氟化硼乙醚、 potassium carbonate 作用下，以二氯甲烷为溶剂，反应 24.0h，生成 1-O-[4-(hexadecylthio)-2-ethoxybutyl]-β-D-galactopyranosyl-(1–4)-β-D-glucopyranoside

参考文献：

名称：

硫醚官能化的糖脂两亲化合物显示出SK3通道的有效活化剂，具有血管舒张作用

摘要：

通过使用两亲性化合物Ohmline（糖-甘油-醚-脂质），可以有效和选择性地实现SK3离子通道的调节。我们在此报告了一系列欧姆线类似物，其特征在于位于相同位置或接近其初始位置的硫醚官能团取代了一个醚官能团。脂质链长度的变化以及以一个亚砜或一个砜部分为特征的两种类似物的制备完成了该系列。膜片钳测量表明，硫醚官能团（化合物7和17a）的存在会产生SK3通道的强活化剂，而在同一位置引入亚砜或砜官能团会产生两亲物，而对SK3通道没有影响。化合物7和17a是首个具有SK3通道强烈激活（接近200％激活）功能的两亲化合物。从化合物3b的3个不同时间（13分钟，1小时，24小时）的荧光确定的细胞溶质钙浓度表明效果不同，表明该化合物可随时间代谢。该化合物可在短时间内用作强力SK3活化剂。然后将7b激活SK3的能力通过内皮衍生的超极化（EDH）途径诱导血管舒张。我们首次报道两亲化合物可影响内皮依赖性血管舒张。

DOI：

10.1039/d1ob00021g
作为产物：

描述：

环氧丁烯在乙醇、三氟化硼乙醚作用下，生成 2-乙氧基-3-丁烯-1-醇

参考文献：

名称：

Petrow, Zhurnal Obshchei Khimii, 1946, vol. 16, p. 1629

摘要：

DOI：

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文献信息

Macrocyclic kinase inhibitors

申请人：Lin Nan-Horng

公开号：US20050215556A1

公开（公告）日：2005-09-29

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

具有以下化学式的化合物对抑制蛋白激酶很有用。还公开了制备这些化合物的方法、含有这些化合物的组合物，以及使用这些化合物进行治疗的方法。
HYDROFORMYLATION CATALYSTS

申请人：Tolleson Ginette Struck

公开号：US20090299099A1

公开（公告）日：2009-12-03

This invention is directed to a class of compounds that can be both monodentate and bidentate in their association with a transition metal to form a catalyst for reactions such as the hydroformylation of olefins to produce aldehydes. The compounds contain two phosphorus atoms having different steric and/or electronic nature. In hydroformylation catalysts, the compounds advantageously can produce a variable n/iso product mixture of aldehyde products that can be varied by simply changing process variables such as [H 2 ]/[CO] partial pressure gas ratio or temperature/inert gas partial pressure.

这项发明涉及一类化合物，这些化合物在与过渡金属结合形成催化剂时既可以是一齿的，也可以是二齿的，用于反应如烯烃的氢甲酰化，以产生醛类产物。这些化合物包含两个磷原子，具有不同的空间位阻和/或电子性质。在氢甲酰化催化剂中，这些化合物有利地可以产生可变的n/iso醛类产物混合物，可以通过简单改变过程变量，如[H2]/[CO]分压气体比或温度/惰性气体分压来进行调整。
[EN] NEW GLYCOLIPIDS AND USE THEREOF AS SK3 ION CHANNEL MODULATORS<br/>[FR] NOUVEAUX GLYCOLIPIDES ET LEUR UTILISATION EN TANT QUE MODULATEURS DE CANAUX IONIQUES SK3

申请人：UNIV BRETAGNE OCCIDENTALE

公开号：WO2022013430A1

公开（公告）日：2022-01-20

The present invention relates to new glycolipids derivatives of Formula (I) and their use in the treatment of diseases related with a deregulation of the expression and/or activity of SK3 ion channels. The present invention further relates to pharmaceutical compositions comprising compounds of Formula (I) for use in the treatment of diseases related with a deregulation of the expression and/or activity of SK3 ion channels.

本发明涉及公式（I）的新型糖脂衍生物及其在治疗与SK3离子通道的表达和/或活性失调相关的疾病中的应用。本发明还涉及含有公式（I）化合物的药物组合物，用于治疗与SK3离子通道的表达和/或活性失调相关的疾病。
[EN] MACROCYCLIC KINASE INHIBITORS<br/>[FR] INHIBITEURS MACROCYCLIQUES DE KINASES

申请人：ABBOTT LAB

公开号：WO2005047294A1

公开（公告）日：2005-05-26

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds

具有式(I)的化合物对于抑制蛋白激酶具有用途。还公开了制备该化合物的方法，含有该化合物的组合物，以及使用该化合物进行治疗的方法。
Petrow, Doklady Akademii Nauk SSSR, 1945, vol. 50, p. 249

作者：Petrow

DOI：——

日期：——

2-乙氧基-3-丁烯-1-醇 | 34684-08-7

分子结构分类

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安全信息

SDS

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