2-乙氧基-5-甲基吡嗪 | 67845-34-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-乙氧基-5-甲基吡嗪
• 英文名称: 2-ethoxy-5-methylpyrazine
• CAS: 67845-34-5
• 化学式: C₇H₁₀N₂O
• mdl: MFCD00055036
• 分子量: 138.169
• InChiKey: MGDMTRSONRZXOH-UHFFFAOYSA-N

物化性质

• 沸点：
  189.1±35.0 °C(Predicted)
• 密度：
  1.041±0.06 g/cm3(Predicted)
• LogP：
  1.74
• 保留指数：
  1047;1047

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2-乙氧基-5-甲基吡嗪 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 以32%的产率得到2-(bromomethyl)-5-ethoxypyrazine
  参考文献：
  名称：

  [EN] TRPV4 ANTAGONISTS
  [FR] ANTAGONISTES DE TRPV4

  摘要：

  本发明涉及式（I）中的螺环氨基甲酸酯化合物，其中R1，（R2）Y，R3，R4，X和A具有规范中给定的含义。该发明还提供含有这些化合物或其药用可接受盐的药物组合物，并涉及将这些化合物用作TRPV4拮抗剂以治疗或预防与TRPV4失衡相关的疾病。

  公开号：

  WO2013012500A1

文献信息

• IDO INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160289171A1

  公开（公告）日：2016-10-06

  There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

  已披露的化合物可调节或抑制吲哌酮胺2,3-二氧化酶（IDO）的酶活性，含有该化合物的药物组合物以及利用本发明的化合物治疗增殖性疾病，如癌症、病毒感染和/或炎症性疾病的方法。
• REAGENT FOR ORGANIC SYNTHESIS REACTION CONTAINING ORGANIC TRIOL BORATE SALT
  申请人：Miyaura Norio

  公开号：US20100087646A1

  公开（公告）日：2010-04-08

  [Problem] To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. [Means for Solving Problems] The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

  [问题] 提供一种含有有机硼化合物的试剂，用于有机合成反应，该试剂不会发生脱水三聚体化，无需碱激活，稳定且活性高。 [解决问题的方法] 用于有机合成反应的试剂包含由通式(I)至(III)和通式(XVI)中的任一表示的有机三醇硼酸盐，其中R1代表烷基、烯基等；R2代表可选择取代的烷基、烯基、炔基等，或代表氢；m+代表碱金属离子、磷酰离子或给定的铵离子；M2+代表碱土金属；X代表卤素或烷氧基；Y代表碱金属离子等；A代表可选择取代的亚甲基；n代表整数。
• [EN] 2,3,4,5-TETRAHYDROPYRIDIN-6-AMINE DERIVATIVES<br/>[FR] DÉRIVÉS DE 2,3,4,5-TÉTRAHYDROPYRIDINE-6-AMINE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2017050978A1

  公开（公告）日：2017-03-30

  The present invention relates to 2,3,4,5-tetrahydropyridin-6-amine compound inhibitors of beta-secretase having the structure shown in Formula (I) wherein the radicals are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, or dementia associated with beta-amyloid.

  本发明涉及具有如公式(I)所示结构的β-分泌酶抑制剂2,3,4,5-四氢吡啶-6-胺化合物，其中基团如规范中所定义。该发明还涉及包括这些化合物的药物组合物，用于制备这些化合物和组合物的方法，以及利用这些化合物和组合物预防和治疗涉及β-分泌酶的疾病，如阿尔茨海默病（AD）、轻度认知障碍、老年痴呆、带有Lewy小体的痴呆、唐氏综合征、与中风相关的痴呆、与帕金森病相关的痴呆或与β-淀粉样蛋白相关的痴呆。
• Prevention of Illicit Manufacutre of Methamphetamine from Pseudoephedrine Using Food Flavor Excipients
  申请人：Satara Pharmaceuticals, LLC

  公开号：US20160089439A1

  公开（公告）日：2016-03-31

  The invention relates generally to ephedrine or pseudoephedrine compositions containing biocompatible organoleptic (food flavoring) excipients that would prevent the illicit manufacture of methamphetamine from ephedrine or pseudoephedrine.

  该发明通常涉及含有生物相容性感官（食品调味）赋形剂的麻黄碱或伪麻黄碱组合物，可防止从麻黄碱或伪麻黄碱制备冰毒。
• [EN] PREVENTION OF ILLICIT METHAMPHETAMINE MANUFACTURE FROM PSEUDOEPHEDRINE USING FOOD FLAVOR EXCIPIENTS<br/>[FR] PRÉVENTION DE LA FABRICATION ILLICITE DE MÉTHAMPHÉTAMINE À PARTIR DE PSEUDOÉPHÉDRINE À L'AIDE D'ARÔMES ALIMENTAIRES
  申请人：DAYA DRUG DISCOVERIES INC

  公开号：WO2015048597A1

  公开（公告）日：2015-04-02

  The invention relates generally to ephedrine or pseudoephedrine compositions containing biocompatible organoleptic excipients that would prevent the illicit manufacture of methamphetamine from ephedrine or pseudoephedrine. The organoleptic agents, typically used as food flavorings, are pyrazine based excipients, that when co-formulated with ephedrine or pseudoephedrine, prevent the isolation and converasion of pure methamphetamine.

  该发明通常涉及含有生物相容性感官助剂的麻黄碱或伪麻黄碱组合物，这些感官助剂可以防止从麻黄碱或伪麻黄碱制备冰毒。这些感官助剂通常用作食品香料，是基于吡嗪的助剂，与麻黄碱或伪麻黄碱共同配制时，可以防止纯冰毒的分离和转化。