2-乙氧基乙硫醇 | 17362-04-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-乙氧基乙硫醇
• 英文名称: 2-mercaptoethyl ether
• 英文别名: 2-ethoxy-ethanethiol；2-Ethoxyethanethiol
• CAS: 17362-04-8
• 化学式: C₄H₁₀OS
• mdl: MFCD00039657
• 分子量: 106.189
• InChiKey: ZKHZEAOYIJBZBM-UHFFFAOYSA-N

物化性质

• 沸点：
  37-40 °C(Press: 15 Torr)
• 密度：
  0.9412 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  6
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  10.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  2-乙氧基乙硫醇 在 乙醇 、 碘 作用下， 生成 2-ethoxyethyl disulfide
  参考文献：
  名称：

  Swallen; Boord, Journal of the American Chemical Society, 1930, vol. 52, p. 655

  摘要：

  DOI：
• 作为产物：
  描述：

  2-乙氧基氯乙烷 在 甲醇 、 potassium hydrosulfide 作用下， 生成 2-乙氧基乙硫醇
  参考文献：
  名称：

  Swallen; Boord, Journal of the American Chemical Society, 1930, vol. 52, p. 655

  摘要：

  DOI：

文献信息

• Preparation of penem derivatives and azetidinone intermediates
  申请人：Pfizer Inc.

  公开号：US04595539A1

  公开（公告）日：1986-06-17

  Certain 2-substituted-2-penem-3-carboxylic acid compounds and pharmaceutically-acceptable salts thereof can be prepared from the appropriate xanthate or trithiocarbonate by desulfurization and addition of an electrophilic sulfur compound followed by halogenation and ring closure. The corresponding desulfurized and halogenated olefinic intermediates are disclosed.

  某些2-取代-2-氧杂-3-羧酸化合物及其药用可接受的盐可以通过适当的硫代硫酸盐或三硫代碳酸酯经过脱硫、加入亲电子硫化合物，随后进行卤素化和环合反应来制备。相应的脱硫和卤素化的烯丙基中间体也被披露。
• [EN] COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE MODULATION DE L'ACTIVITÉ DE LA DÉSHYDROGÉNASE À CHAÎNE COURTE
  申请人：UNIV CASE WESTERN RESERVE

  公开号：WO2018218251A1

  公开（公告）日：2018-11-29

  Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

  化合物的15-PGDH活性调节方法、组织前列腺素水平调节、疾病治疗、疾病紊乱或希望调节15-PGDH活性和/或前列腺素水平的状况包括本文描述的15-PGDH抑制剂。
• 2-(Alkylthio)penem-3-carboxylic acids I. Synthesis of 6-unsubstituted penems.
  作者：SADAO OIDA、AKIRA YOSHIDA、TERUO HAYASHI、NORIKO TAKEDA、EIJI OHKI

  DOI：10.1248/cpb.28.3232

  日期：——

  Treatment of 4-acetoxy-2-azetidinone (9) with various sodium alkyl trithiocarbonates gave 4-[(alkylthio) thiocarbonyl] thioazetidinones 10, which were converted into the phosphoranes 8. Intramolecular Wittig reactions of 8 followed by deblocking yielded penem-3-carboxylic acids 5.

  用各种烷基三硫代碳酸钠处理4-乙酰氧基-2-氮杂环丁酮（9）得到了4-[(烷硫基)硫代羰基]硫代氮杂环丁酮10，这些化合物被转化为磷叶立德8。8的分子内Wittig反应随后进行脱保护反应生成了青霉烯-3-羧酸5。
• 2-(Alkylthio)penem-3-carboxylic acids. V. Synthesis and antibacterial activities of "1-thiathienamycin" and related compounds.
  作者：TERUO HAYASHI、AKIRA YOSHIDA、NORIKO TAKEDA、SADAO OIDA、SHINICHI SUGAWARA、EIJI OHKI

  DOI：10.1248/cpb.29.3158

  日期：——

  The synthesis of optically active "1-thiathienamycin"13a and other (hydroxyethyl)-penemcarboxylic acids from the 8R and 8S azetidinones 3 and 4 via an intramolecular Wittig reaction of the trithiocarbonatephosphoranes 7 is described. Trans and cis penem esters 8 and 9 were found to form an equilibrium mixture on heating. The antibacterial activities of these penemcarboxylic acids are discussed.

  描述了从8R和8S氮杂环丁酮3和4通过三硫代碳酸盐磷烯7的分子内维提格反应合成光学活性的“1-噻噢噻喃霉素”13a及其他（羟乙基）-青霉酰酸。发现反式和顺式青霉酯8和9在加热时形成平衡混合物。讨论了这些青霉酰酸的抗菌活性。
• [EN] 3-PYRIDYL HETEROBICYCLIC COMPOUND FOR CONTROLLING INVERTEBRATE PESTS<br/>[FR] COMPOSÉ HÉTÉROBICYCLIQUE DE 3-PYRIDYLE UTILISÉ POUR LUTTER CONTRE LES INVERTÉBRÉS NUISIBLES
  申请人：BASF SE

  公开号：WO2016071499A1

  公开（公告）日：2016-05-12

  The present invention relates to the use of substituted 3-pyridyl heterobicyclic compounds of formula I as agrochemical pesticides. Furthermore, the present invention relates to novel substituted 3-pyridylheterobicyclic compounds of formula I* as well as to processes and intermediates for preparing them, and also to active compound combinations comprising them, to compositions comprising them, and to their use for protecting growing plants from attack or infestation by invertebrate pests. Furthermore, the invention relates to methods of applying the compounds of I, or I*. The present invention also relates to seed comprising such compounds.

  本发明涉及将式I的取代3-吡啶基杂双环化合物用作农药杀虫剂。此外，本发明涉及新的取代的式I*的3-吡啶基杂双环化合物，以及用于制备它们的过程和中间体，以及包含它们的活性化合物组合物，包含它们的组合物，以及它们用于保护植物免受无脊椎动物害虫攻击或侵袭的用途。此外，本发明涉及应用式I或I*的化合物的方法。本发明还涉及包含这种化合物的种子。