8-(4-methoxyphenyl)octanoic acid | 24536-02-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 8-(4-methoxyphenyl)octanoic acid
• 英文别名: 8-(p-Methoxyphenyl)octanoic acid；8-p-Anisyloctansaeure
• CAS: 24536-02-5
• 化学式: C₁₅H₂₂O₃
• 分子量: 250.338
• InChiKey: VJYGGMSKWJPHJO-UHFFFAOYSA-N

物化性质

• 熔点：
  50-52 °C
• 沸点：
  408.0±28.0 °C(Predicted)
• 密度：
  1.043±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-(4-methoxyphenyl)octanoic acid 、 氢溴酸 、 溶剂黄146 生成 8-(4-Hydroxyphenyl)octansaeure
  参考文献：
  名称：

  AULTZ D. E.; MCFADDEN A. R., J. MED. CHEM. , 1977, 20, NO 11, 1499-1501

  摘要：

  DOI：
• 作为产物：
  描述：

  8-(p-Methoxyphenyl)-7-octenoic acid 在 Pd barium sulfate petroleum ether 作用下， 以afforded the product (1.20 g, 96%) as white crystals (mp 42-43° C.)的产率得到8-(4-methoxyphenyl)octanoic acid
  参考文献：
  名称：

  Thienyl-containing fatty acid glycosyl phosphatidylinosital analogues

  摘要：

  本发明揭示了一种抑制寄生虫活动的方法，其中可以通过将所述GPI锚中选择的肉豆蔻酸类似物包含其中来影响所述寄生虫的生物合成、结构和/或功能，所述肉豆蔻酸类似物包括含有各种杂原子、取代基和不饱和键的酯类类似物、酮羰基类类似物、含硫类类似物、双键和三键含有类类似物、芳香基含有类类似物、硝基类类似物和卤代类类似物。

  公开号：

  US05998642A1

文献信息

• On the Importance of the Relative Stereochemistry of Substituents in the Formation of Nine-Membered Lactones by Ring-Closing Metathesis
  作者：Stephen Hanessian、Jean-Philippe Cusson、Etienne Chénard

  DOI：10.1055/s-0034-1380130

  日期：——

  The effects of isopropyl substituents and molar concentration of diastereomeric esters toward the formation of nine-membered unsaturated lactones, in the context of the synthesis of the intermediates of the antihypertensive drug aliskiren, have been studied. The effects of isopropyl substituents and molar concentration of diastereomeric esters toward the formation of nine-membered unsaturated lactones

  摘要 在合成降压药阿利吉仑中间体的背景下，研究了异丙基取代基和非对映异构体酯的摩尔浓度对九元不饱和内酯形成的影响。 在合成降压药阿利吉仑中间体的背景下，研究了异丙基取代基和非对映异构体酯的摩尔浓度对九元不饱和内酯形成的影响。
• Method of inhibiting parasitic activity
  申请人：Washington University

  公开号：US06001869A1

  公开（公告）日：1999-12-14

  A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.

  揭示一种抑制寄生活动的方法，其中可以通过将所述GPI锚中选择的肉豆蔻酸类似物包括不同的杂原子、取代基和不饱和键，包括酯类类似物、酮羰基类似物、含硫类似物、双键和三键含有类似物、芳香基团含有类似物、硝基类似物和卤素类似物，来影响所述寄生物的GPI锚的生物合成、结构和/或功能。
• Thienyl-containing fatty acid glycosyl phosphatidylinosital analogues
  申请人：Washington University

  公开号：US05998642A1

  公开（公告）日：1999-12-07

  A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.

  本发明揭示了一种抑制寄生虫活动的方法，其中可以通过将所述GPI锚中选择的肉豆蔻酸类似物包含其中来影响所述寄生虫的生物合成、结构和/或功能，所述肉豆蔻酸类似物包括含有各种杂原子、取代基和不饱和键的酯类类似物、酮羰基类类似物、含硫类类似物、双键和三键含有类类似物、芳香基含有类类似物、硝基类类似物和卤代类类似物。
• EP300/CREBBP INHIBITOR
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20210171520A1

  公开（公告）日：2021-06-10

  The present invention provides a compound having excellent histone acetyl transferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q 1 , ring Q 2 , R 1 , R 2 , R 3 and R 4 respectively have the same meanings as defined in the specification.
• US5747537A
  申请人：——

  公开号：US5747537A

  公开（公告）日：1998-05-05