1-(3-fluorophenyl)-2,2-bis(1-methyl-1H-indol-3-yl)ethanone | 1447946-94-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3-fluorophenyl)-2,2-bis(1-methyl-1H-indol-3-yl)ethanone
• 英文别名: 1-(3-Fluorophenyl)-2,2-bis(1-methylindol-3-yl)ethanone；1-(3-fluorophenyl)-2,2-bis(1-methylindol-3-yl)ethanone
• CAS: 1447946-94-2
• 化学式: C₂₆H₂₁FN₂O
• 分子量: 396.464
• InChiKey: TXMITAFODBJOMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-甲基吲哚 、 3-氟苯乙烯 在 碘 、 二甲基亚砜 、 2-碘酰基苯甲酸 作用下， 以 二甲基亚砜 为溶剂， 反应 7.0h， 以63%的产率得到1-(3-fluorophenyl)-2,2-bis(1-methyl-1H-indol-3-yl)ethanone
  参考文献：
  名称：

  I2-promoted direct one-pot synthesis of 2,2-bisindolyl-1-arylethanones from multiform substrates arylethenes, 2-hydroxy-aromatic ketones, and carbinols

  摘要：

  An I-2-promoted domino protocol was developed to construct 2,2-bisindolyl-1-arylethanones from multiform substrates arylethenes, 2-hydroxy-aromatic ketones, and carbinols via three distinct pathways. Through a logical coupled oxidation/Friedel-Crafts alkylation domino process, a variety of 2,2-bisindolyl-1-arylethanones were synthesized in one-pot. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.06.054

文献信息

• I2-promoted direct one-pot synthesis of 2,2-bisindolyl-1-arylethanones from multiform substrates arylethenes, 2-hydroxy-aromatic ketones, and carbinols
  作者：Feng-Cheng Jia、Yan-Ping Zhu、Mei-Cai Liu、Mi Lian、Qing-He Gao、Qun Cai、An-Xin Wu

  DOI：10.1016/j.tet.2013.06.054

  日期：2013.8

  An I-2-promoted domino protocol was developed to construct 2,2-bisindolyl-1-arylethanones from multiform substrates arylethenes, 2-hydroxy-aromatic ketones, and carbinols via three distinct pathways. Through a logical coupled oxidation/Friedel-Crafts alkylation domino process, a variety of 2,2-bisindolyl-1-arylethanones were synthesized in one-pot. (C) 2013 Elsevier Ltd. All rights reserved.