2-乙酰氨基-2,6-二脱氧葡萄糖 | 40614-71-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-乙酰氨基-2,6-二脱氧葡萄糖
• 英文名称: N-Acetyl-6-deoxy-D-glucosamin
• 英文别名: 2-Acetamido-2,6-dideoxy-D-glucose；2-acetylamino-2,6-dideoxy-D-glucose；2-Acetylamino-2,6-didesoxy-D-glucose；N-(6-Desoxy-D-glucose-2-yl)-acetamid；2-Acetamido-2,6-dideoxyglucose；N-[(2R,3R,4R,5R)-3,4,5-trihydroxy-1-oxohexan-2-yl]acetamide
• CAS: 40614-71-9
• 化学式: C₈H₁₅NO₅
• 分子量: 205.211
• InChiKey: CZRYIXLKTDHMMY-PXBUCIJWSA-N

物化性质

• 熔点：
  209-211 °C (decomp)
• 沸点：
  551.8±50.0 °C(Predicted)
• 密度：
  1.299±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  2-乙酰氨基-2,6-二脱氧葡萄糖 、 乙酸酐 在 zinc(II) chloride 作用下， 生成 tri-O-acetyl-2-acetylamino-2,6-dideoxy-β-D-glucopyranose 、 2-acetamido-2,6-dideoxy-1,3,4-tri-O-acetyl-α-D-glucose
  参考文献：
  名称：

  Kuhn; Bister; Dafeldecker, Justus Liebigs Annalen der Chemie, 1958, vol. 617, p. 118,125

  摘要：

  DOI：
• 作为产物：
  描述：

  tri-O-acetyl-2-acetylamino-2,6-dideoxy-β-D-glucopyranose 在 氨 作用下， 生成 2-乙酰氨基-2,6-二脱氧葡萄糖
  参考文献：
  名称：

  关于2,6-二脱氧-2-氨基-D-葡萄糖（6-deoxy-D-glucosamine）的表示和性质

  摘要：

  描述了6-脱氧-D-葡糖胺的合成和性质。

  DOI：

  10.1002/hlca.19580410607

文献信息

• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• METHOD AND DEVICE FOR PRODUCING SACCHARIDES AND SACCHARIDE ARRAYS
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3670521A1

  公开（公告）日：2020-06-24

  The present invention relates to a method and a device for producing saccharides and saccharide arrays. Said method is particularly useful for the synthesis of saccharides in parallel and of high-density saccharide arrays, such as microarrays, which are required for high-throughput screenings.

  本发明涉及一种生产糖和糖阵列的方法和装置。该方法特别适用于平行合成糖类和高密度糖类阵列，如高通量筛选所需的微阵列。
• ENZYMATIC METHOD FOR PREPARATION OF GDP-FUCOSE
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3719135A1

  公开（公告）日：2020-10-07

  The present invention relates to an enzyme-catalyzed process for producing GDP-fucose from low-cost substrates guanosine and L-fucose or guanosine and D-Mannose in a single reaction mixture. Said process can be operated (semi)continuously or in batch mode. Further, said process can be adapted to produce fucosylated molecules and biomolecules including glycans, such as human milk oligosaccharides, proteins, peptides, glycoproteins or glycopeptides.

  本发明涉及一种在单一反应混合物中利用低成本底物鸟苷和 L-岩藻糖或鸟苷和 D-甘露糖生产 GDP-岩藻糖的酶催化工艺。所述工艺可（半）连续或分批进行。此外，所述工艺还可用于生产岩藻糖基化分子和生物大分子，包括聚糖，如人乳寡糖、蛋白质、肽、糖蛋白或糖肽。
• QUANTIFICATION OF BIOCONJUGATE GLYCOSYLATION
  申请人：GlaxoSmithKline Biologicals S.A.

  公开号：EP3770269A1

  公开（公告）日：2021-01-27

  The present invention provides analytical tools for the characterisation of bioconjugates, in particular the measurement of glycosylation levels. Methods for absolute quantification of glycosylation sequences are disclosed, as are novel sequences and glycosylation sites for use in such methods.

  本发明为生物共轭物的表征，特别是糖基化水平的测量提供了分析工具。本发明公开了对糖基化序列进行绝对定量的方法，以及用于此类方法的新型序列和糖基化位点。
• ENZYMATIC METHOD FOR PREPARATION OF UDP-GALACTOSE
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3819381A1

  公开（公告）日：2021-05-12

  The present invention relates to an enzyme-catalyzed process for producing UDP-galactose from low-cost substrates uridine monophosphate and D-galactose in a single reaction mixture. Said process can be operated (semi)continuously or in batch mode. Further, said process can be adapted to produce galactosylated molecules and biomolecules including saccharides, proteins, peptides, glycoproteins or glycopeptides, particularly human milk oligosaccharides (HMO) and (monoclonal) antibodies.

  本发明涉及一种酶催化工艺，用于在单一反应混合物中以低成本底物单磷酸尿苷和 D-半乳糖为原料生产 UDP-半乳糖。所述工艺可（半）连续或分批进行。此外，所述工艺还可用于生产半乳糖化分子和生物大分子，包括糖、蛋白质、肽、糖蛋白或糖肽，特别是人乳寡糖（HMO）和（单克隆）抗体。