4.6-Dimethyl-heptin-(1)-ol-(4) | 19135-03-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4.6-Dimethyl-heptin-(1)-ol-(4)
• 英文别名: 4,6-Dimethylhept-1-yn-4-ol
• CAS: 19135-03-6
• 化学式: C₉H₁₆O
• 分子量: 140.225
• InChiKey: QAUZCLFAAJZNCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4.6-Dimethyl-heptin-(1)-ol-(4) 在 ion-exchange resin + form> 、 水 作用下， 生成 4-hydroxy-4,6-dimethyl-heptan-2-one
  参考文献：
  名称：

  Plouin,D.; Glenat,R., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1967, vol. 265, p. 595 - 598

  摘要：

  DOI：
• 作为产物：
  描述：

  3-溴丙炔 在 四氢呋喃 、 aluminium amalgam 作用下， 生成 4.6-Dimethyl-heptin-(1)-ol-(4)
  参考文献：
  名称：

  The Prevalence of Daytime Napping and Its Relationship to Nighttime Sleep

  摘要：

  Many healthy adults report daytime napping. Surprisingly few studies, however have examined spontaneous napping behavior especially very short naps, in healthy adults. The authors examined the prevalence of power naps (lasting less than 20 minutes) and longer naps (20 minutes or more) and their effects on nighttime sleep in a group of healthy young and middle-aged adults. The young and middle-aged adults reported very similar sleep and napping patterns, with approximately 74% of the participants in both groups reporting they had napped during a 7-day sleep-log period. Almost half of the participants reported that the average nap lasted less than 20 minutes. A multivariant analysis of variance (MANOVA) found no significant differences between the no-nap and the power-nap or long-nap groups in sleep quantity or quality for either age group. The current data suggested that power napping occurs frequently in healthy adults and that spontaneous napping does not negatively affect nighttime sleep.

  DOI：

  10.1080/08964280109595773

文献信息

• Ready Access to Benzannulated [5,5]-Oxaspirolactones Using Au(III)-Catalyzed Cascade Cyclizations
  作者：Yash Mankad、Sagar S. Thorat、Pronay Das、Gamidi Rama Krishna、Ravindar Kontham、D. Srinivasa Reddy

  DOI：10.1021/acs.joc.1c02843

  日期：2022.3.4

  showcases an unprecedented Au(III)-catalyzed cascade cyclization of 2-(4-hydroxyalkynyl)benzoates to access benzannulated [5,5]-oxaspirolactones related to biologically active natural products. This reaction proceeds through an initial 5-endo-dig mode of hydroalkoxylation of the alkynol segment to give the oxocarbenium species (via cyclic enol-ether) followed by the addition of carboxylate onto the oxocarbenium

  这项工作展示了史无前例的 Au(III) 催化的 2-(4-羟基炔基)苯甲酸酯的级联环化，以获得与生物活性天然产物相关的苯环 [5,5]-氧杂螺内酯。该反应通过炔醇链段的氢化烷氧基化的初始 5 - endo -dig 模式进行，以产生氧代碳鎓物质（通过环烯醇-醚），然后将羧酸盐添加到氧代碳鎓上，从而递送氧螺内酯支架。在测试该方法的范围时，我们发现羟基的空间位阻和电子环境可以改变通过羧酸盐对束缚炔烃的竞争性 6- endo -dig 攻击模式传递异色烯酮的反应途径。
• The Prevalence of Daytime Napping and Its Relationship to Nighttime Sleep
  作者：June J. Pilcher、Kristin R. Michalowski、Renee D. Carrigan

  DOI：10.1080/08964280109595773

  日期：2001.1

  Many healthy adults report daytime napping. Surprisingly few studies, however have examined spontaneous napping behavior especially very short naps, in healthy adults. The authors examined the prevalence of power naps (lasting less than 20 minutes) and longer naps (20 minutes or more) and their effects on nighttime sleep in a group of healthy young and middle-aged adults. The young and middle-aged adults reported very similar sleep and napping patterns, with approximately 74% of the participants in both groups reporting they had napped during a 7-day sleep-log period. Almost half of the participants reported that the average nap lasted less than 20 minutes. A multivariant analysis of variance (MANOVA) found no significant differences between the no-nap and the power-nap or long-nap groups in sleep quantity or quality for either age group. The current data suggested that power napping occurs frequently in healthy adults and that spontaneous napping does not negatively affect nighttime sleep.
• Plouin,D.; Glenat,R., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1967, vol. 265, p. 595 - 598
  作者：Plouin,D.、Glenat,R.

  DOI：——

  日期：——