N-acetylphenylalanine 2-(phenylseleno)ethyl ester | 147092-00-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetylphenylalanine 2-(phenylseleno)ethyl ester
• 英文别名: 2-phenylselanylethyl (2S)-2-acetamido-3-phenylpropanoate
• CAS: 147092-00-0
• 化学式: C₁₉H₂₁NO₃Se
• 分子量: 390.341
• InChiKey: YUDUGNLUTXWLKQ-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.72
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-acetylphenylalanine 2-(phenylseleno)ethyl ester 在 双氧水 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 24.5h， 生成 N-acetyl-L-phenylalanine vinyl ester
  参考文献：
  名称：

  A New Methodology for the Preparation of Vinyl Esters

  摘要：

  新方法已研发成功，用于制备未取代的烯醇酯。通过获得乙烯基芳香α-氨基酸酯，展示了其应用。简要调查制备其他疏水性乙烯酯也取得成功。由于采用温和反应条件，相信这一途径可通向其他烯醇酯。

  DOI：

  10.1055/s-1993-25802
• 作为产物：
  描述：

  2-(phenylselenyl)ethanol 、 N-乙酰-L-苯丙氨酸 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以92%的产率得到N-acetylphenylalanine 2-(phenylseleno)ethyl ester
  参考文献：
  名称：

  A New Methodology for the Preparation of Vinyl Esters

  摘要：

  新方法已研发成功，用于制备未取代的烯醇酯。通过获得乙烯基芳香α-氨基酸酯，展示了其应用。简要调查制备其他疏水性乙烯酯也取得成功。由于采用温和反应条件，相信这一途径可通向其他烯醇酯。

  DOI：

  10.1055/s-1993-25802

文献信息

• Composition that can be cured by polymerisation for the production of biodegradable, biocompatible, cross-linkable polymers on the basis of polyvinyl alcohol
  申请人：Liska Robert

  公开号：US08999323B2

  公开（公告）日：2015-04-07

  The present invention relates to a polymerization-curable composition for the preparation of biodegradable, biocompatible, cross-linked polymers on the basis of polyvinyl alcohol comprising: 5 to 100% by weight of (a) vinyl ester monomer(s) of one of the general formulas (I) to (III): wherein X is oxygen, sulfur, nitrogen, or phosphorus; n is 1 to 1000, at least 20% of the n being ≧2; the R1 are selected from hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups having 1 to 30 carbon atoms, which optionally have heteroatoms and are optionally substituted with one or more substituents selected from —OH, —COON, —CN, —CHO, and ═O, and n-valent radicals of biodegradable, biocompatible oligomers and polymers; m is an integer from 1 to 5; the R2 are selected from hydrogen, —OH, ═O, and the options listed for R1; and the R3 are selected from hydrogen, —OH, and the options listed for R1; 0 to 50% by weight of ethylenically unsaturated co-monomers; 0 to 10% by weight of (a) polymerization initiator(s); and 0 to 95% by weight of solvent(s).

  本发明涉及一种基于聚乙烯醇的聚合固化组合物，用于制备可生物降解、生物相容性、交联聚合物，包括以下成分：5至100重量％的（a）乙烯酸酯单体，其中单体的一般式（I）至（III）之一：其中X为氧、硫、氮或磷；n为1至1000，至少20％的n≧2；R1选自氢；具有1至30个碳原子的直链、支链或环状、饱和或不饱和、n价碳氢基团，其可选地具有杂原子并且可选地被一个或多个取代基所取代，所述取代基选自—OH、—COON、—CN、—CHO和═O，以及可生物降解、生物相容性寡聚物和聚合物的n价基团；m为1至5的整数；R2选自氢、—OH、═O和R1所列出的选项；以及R3选自氢、—OH和R1所列出的选项；0至50重量％的乙烯基不饱和共聚单体；0至10重量％的（a）聚合引发剂；以及0至95重量％的溶剂。
• COMPOSITION THAT CAN BE CURED BY POLYMERISATION FOR THE PRODUCTION OF BIODEGRADABLE, BIOCOMPATIBLE, CROSS-LINKABLE POLYMERS ON THE BASIS OF POLYVINYL ALCOHOL
  申请人：Liska Robert

  公开号：US20100303804A1

  公开（公告）日：2010-12-02

  The present invention relates to a polymerization-curable composition for the preparation of biodegradable, biocompatible, cross-linked polymers on the basis of polyvinyl alcohol comprising: 5 to 100% by weight of (a) vinyl ester monomer(s) of one of the general formulas (I) to (III): wherein X is oxygen, sulfur, nitrogen, or phosphorus; n is 1 to 1000, at least 20% of the n being ≧2; the R 1 are selected from hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups having 1 to 30 carbon atoms, which optionally have heteroatoms and are optionally substituted with one or more substituents selected from —OH, —COON, —CN, —CHO, and ═O, and n-valent radicals of biodegradable, biocompatible oligomers and polymers; m is an integer from 1 to 5; the R 2 are selected from hydrogen, —OH, ═O, and the options listed for R 1 ; and the R 3 are selected from hydrogen, —OH, and the options listed for R 1 ; 0 to 50% by weight of ethylenically unsaturated co-monomers; 0 to 10% by weight of (a) polymerization initiator(s); and 0 to 95% by weight of solvent(s).

  本发明涉及一种聚合固化组合物，用于基于聚乙烯醇制备可生物降解、生物相容的交联聚合物，包括以下成分：5至100重量％的（a）通式（I）至（III）之一的乙烯基酯单体：其中X为氧、硫、氮或磷；n为1至1000，其中至少20％的n≧2；R1为氢；直链、支链或环状、饱和或不饱和、具有1至30个碳原子的n价碳氢基团，可选地具有杂原子，并且可选地被一个或多个取代基所取代，所述取代基选择自—OH、—COON、—CN、—CHO和═O，以及可生物降解、生物相容的寡聚物和聚合物的n价基团；m为1至5的整数；R2为氢、—OH、═O和R1中列出的选项；以及R3为氢、—OH和R1中列出的选项；0至50重量％的乙烯基不饱和共聚单体；0至10重量％的（a）聚合引发剂；以及0至95重量％的溶剂。
• A New Methodology for the Preparation of Vinyl Esters
  作者：Michael I. Weinhouse、Kim D. Janda

  DOI：10.1055/s-1993-25802

  日期：——

  A new methodology has been developed for the preparation of unsubstituted enol esters. Its application is demonstrated by the obtainment of vinyl aromatic α-amino esters. A brief investigation of the preparation of other hydrophobic vinyl esters proved successful. Because of the mild reaction conditions employed, it is believed this route should provide access to other enol esters.

  新方法已研发成功，用于制备未取代的烯醇酯。通过获得乙烯基芳香α-氨基酸酯，展示了其应用。简要调查制备其他疏水性乙烯酯也取得成功。由于采用温和反应条件，相信这一途径可通向其他烯醇酯。