Total syntheses of justicidin B and retrojusticidin B using a tandem Horner–Emmons–Claisen condensation sequence
作者:David C Harrowven、Mark Bradley、J Lois Castro、Stuart R Flanagan
DOI:10.1016/s0040-4039(01)01436-8
日期:2001.9
Short syntheses of justicidin B 1 and retrojusticidin B 4 are reported. The key feature is a new annulation reaction, involving a base induced union of ketoaldehyde 2 and phosphonate 3. that is used to construct the highly substituted naphthalene core. (C) 2001 Elsevier Science Ltd. All rights reserved.