2-十六烷酰胺基-2-脱氧-D-吡喃葡萄糖 | 74058-79-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-十六烷酰胺基-2-脱氧-D-吡喃葡萄糖
• 英文名称: 2-hexadecanoylamido-2-deoxy-D-glucopyranose
• 英文别名: 2-deoxy-2-(hexadecanoylamino)-D-glucose；N-hexadecanoyl-α-D-glucosamine；2-palmitoylamino-2-deoxy-D-glucose；N-palmitoyl-D-glucosamine；N-Palmitoyl-D-glucosamin；N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]hexadecanamide
• CAS: 74058-79-0
• 化学式: C₂₂H₄₃NO₆
• 分子量: 417.587
• InChiKey: MGPASPKEZKCJFU-DYDAQHSGSA-N

物化性质

• 沸点：
  639.4±55.0 °C(Predicted)
• 密度：
  1.11±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  29
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  119
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-十六烷酰胺基-2-脱氧-D-吡喃葡萄糖 在 吡啶 、 羟胺 作用下， 反应 48.0h， 以68%的产率得到
  参考文献：
  名称：

  半乳糖和氨基葡萄糖两亲肟的有效合成

  摘要：

  已合成并表征了半乳糖和葡糖胺的新型两亲肟。肟官能团已被引入非离子表面活性剂的第一和第六位置，该非离子表面活性剂由糖极性头和亲脂性侧链组成。该化合物可溶于吡啶，微溶于其他极性有机溶剂和水。

  DOI：

  10.1016/j.tetlet.2012.02.086
• 作为产物：
  描述：

  棕榈酰氯 以 甲醇 为溶剂， 生成 2-十六烷酰胺基-2-脱氧-D-吡喃葡萄糖
  参考文献：
  名称：

  Notes- N-Acylation of 2-Amino-2-deoxy-D-glucose with Mixed Carboxylic Acid Anhydrides

  摘要：

  DOI：

  10.1021/jo01077a627

文献信息

• One-flask synthesis of triacetalated aldohexoses with 2,2-dialkoxypropane and p-toluenesulfonic acid
  作者：Makoto Kiso、Akihiro Kondo、Yumi Kondo、Akira Hasegawa

  DOI：10.1016/0008-6215(84)85110-1

  日期：1984.4

  - arabino -hexose and some N -protected 2-amino-2-deoxy- d -glucose derivatives were each treated with 2,2-dimethoxy- or 2,2-dibenzyloxy-propane in 1,4-dioxane in the presence of p -toluenesulfonic acid at 60–70°. The major products were acyclic, dimethyl and dibenzyl acetals of 2-deoxy-3,4:5,6-di- O -isopropylidene- aldehydo - d - arabino -hexose or of N -protected 2-amino-2-deoxy-3,4:5,6-di- O -isopropylidene-

  摘要将2-脱氧-d-阿拉伯糖己糖和一些N-保护的2-氨基-2-脱氧-d-葡萄糖衍生物分别在1,4-中用2,2-二甲氧基或2,2-二苄氧基丙烷处理。在对甲苯磺酸存在下于60–70°下形成二恶烷。主要产物是2-脱氧-3,4：5,6-二-O-异亚丙基-醛-d-阿拉伯糖-己糖或N-保护的2-氨基-2-脱氧-3的无环，二甲基和二苄基缩醛，4：5,6-二-O-异亚丙基-醛-d-葡萄糖。一些二苄基乙缩醛以良好的产率转化为相应的3,4：5,6-二-O-异亚丙基-醛-d-己糖。
• N-PALMITOYL-D-GLUCOSAMINE IN A MICRONIZED FORM
  申请人：Innovet Italia S.r.l.

  公开号：EP3546469A1

  公开（公告）日：2019-10-02

  The present invention relates to an N-palmitoyl-D-glucosamine-based composition in a micronized form, optionally in combination with Curcumin. In particular, the present invention relates to N-palmitoyl-D-glucosamine in a micronized or co-micronized form with Curcumin. Such a product can be formulated in human or veterinary pharmaceutical compositions, dietetic products, food supplements, or foods for special medical purposes (FSMP), or in feeds, or nutritional supplements for animals for the treatment of chronic systemic inflammatory diseases, in humans and animals, resulting from dysfunctions of epithelia and synovial membranes.

  本发明涉及一种微粉化形式的 N-棕榈酰-D-葡糖胺组合物，可选择与姜黄素结合使用。 特别是，本发明涉及微粉化或与姜黄素共同微粉化形式的 N-棕榈酰-D-葡糖胺。这种产品可配制成人用或兽用药物组合物、膳食产品、食品补充剂或特殊医学用途食品（FSMP），或配制成饲料或动物营养补充剂，用于治疗人和动物因上皮和滑膜功能障碍而引起的慢性全身性炎症性疾病。
• Monoclonal antibodies targeting glypican-2 (GPC2) and use thereof
  申请人：The U.S.A., as represented by the Secretary, Department of Health and Human Services

  公开号：US11066479B2

  公开（公告）日：2021-07-20

  A panel of human variable heavy (VH) single domain monoclonal antibodies specific for cell-surface glypican-2 (GPC2) are described. Methods for the diagnosis and treatment and GPC2-positive cancer are also described. Recombinant immunotoxins comprised of a GPC2-specific VH domain antibody and a clinically used form of Pseudomonas exotoxin A (PE38) were generated and shown to inhibit GPC2-positive neuroblastoma tumor cell growth and inhibit neuroblastoma xenograft growth in nude mice, without significant toxicity. Chimeric antigen receptors comprising a GPC2-specific VH single domain antibody are also described. T cells expressing the GPC2-specific CARs potently killed GPC2-positive neuroblastoma cells in a dose-dependent manner.

  本文描述了一组特异于细胞表面糖蛋白-2（GPC2）的人类可变重型（VH）单克隆抗体。还介绍了诊断和治疗 GPC2 阳性癌症的方法。由 GPC2 特异性 VH 结构域抗体和临床上常用的假单胞菌外毒素 A（PE38）组成的重组免疫毒素已经产生，并证明可抑制 GPC2 阳性神经母细胞瘤肿瘤细胞的生长和抑制神经母细胞瘤异种移植在裸鼠体内的生长，且无明显毒性。此外，还介绍了由 GPC2 特异性 VH 单结构域抗体组成的嵌合抗原受体。表达 GPC2 特异性 CAR 的 T 细胞能以剂量依赖的方式有效杀死 GPC2 阳性的神经母细胞瘤细胞。
• Human monoclonal antibodies specific for FLT3 and uses thereof
  申请人：The U.S.A., as represented by the Secretary, Department of Health and Human Services

  公开号：US11236171B2

  公开（公告）日：2022-02-01

  Human monoclonal antibodies that specifically bind Fms-like tyrosine kinase 3 (FLT3) are described. Chimeric antigen receptors (CARs) and other antibody conjugates that include the FLT3-specific monoclonal antibodies are also described. Methods for the diagnosis and treatment of FLT3-associated cancer, such as acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML), are further described.

  本文介绍了能特异性结合Fms样酪氨酸激酶3（FLT3）的人类单克隆抗体。此外，还介绍了嵌合抗原受体（CAR）和其他包含 FLT3 特异性单克隆抗体的抗体共轭物。还描述了诊断和治疗 FLT3 相关癌症（如急性淋巴细胞白血病（ALL）或急性髓性白血病（AML））的方法。
• Human monoclonal antibody targeting TNFR2 for cancer immunotherapy
  申请人：The U.S.A., as represented by the Secretary, Department of Health and Human Services

  公开号：US11389480B2

  公开（公告）日：2022-07-19

  A human monoclonal antibody that specifically binds tumor necrosis factor receptor 2 (TNFR2), and a defucosylated form of the antibody, are described. The TNFR2-specific antibody was isolated from a human scFv phage display antibody library. The disclosed antibodies promote antibody-dependent cell-mediated cytotoxicity (ADCC) of human TNFR2+ CD4+ T regulatory cells in a dose- and time-dependent manner. Methods of using the TNFR2 antibodies, such as for tumor immunotherapy, are described.

  本文描述了一种能特异性结合肿瘤坏死因子受体 2（TNFR2）的人类单克隆抗体以及该抗体的一种去核糖形式。TNFR2 特异性抗体是从人类 scFv 噬菌体展示抗体库中分离出来的。所公开的抗体以剂量和时间依赖性的方式促进人 TNFR2+ CD4+ T 调节细胞的抗体依赖性细胞介导的细胞毒性（ADCC）。还描述了使用 TNFR2 抗体的方法，如用于肿瘤免疫疗法。