2-hydroxychalcone | 54519-12-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-hydroxychalcone
• 英文别名: α-hydroxy-chalcone；α-Hydroxy-chalkon；ω-Oxy-ω-benzyliden-acetophenon；1,3-Diphenyl-propan-1,2-dion；Hydroxybenzal-acetophenon；2-hydroxy-1,3-diphenylprop-2-en-1-one
• CAS: 54519-12-9
• 化学式: C₁₅H₁₂O₂
• 分子量: 224.259
• InChiKey: BZLYUDJOVAMKIB-UHFFFAOYSA-N

物化性质

• 熔点：
  89-90 °C
• 沸点：
  398.5±42.0 °C(Predicted)
• 密度：
  1.198±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxychalcone 在 乙醚 、 镍 作用下， 生成 1-羟基-1,3-二苯基丙烷-2-酮
  参考文献：
  名称：

  Effect of phenobarbitone on the low-dose dexamethasone suppression test and the urinary corticoid: creatinine ratio in dogs

  摘要：

  ObjectivesTo investigate potential effects of phenobarbitone on the low‐dose dexamethasone suppression (LDDS) test and urinary corticoid to creatinine ratio in dogs in a controlled prospective study and in a clinical setting.AnimalsTen crossbreed experimental dogs and 10 client‐owned dogs of mixed breeds treated chronically with phenobarbitone to control seizures.ProceduresExperimental dogs were allocated to treatment (6 mg/kg oral phenobarbitone, n = 6) and control (n = 4) groups. LDDS tests (dexamethasone 0.01 mg/kg intravenously, cortisol concentration determined at 0, 2, 4, 6 and 8 h) were conducted repeatedly over a 3‐month period. Urinary corticoid to creatinine ratios were measured before LDDS tests. A single LDDS test was performed on 10 epileptic dogs.ResultsLDDS and urinary corticoid to creatinine ratios in dogs were not affected by treatment with phenobarbitone.ConclusionsPhenobarbitone does not interfere with LDDS testing regardless of dosage or treatment time. Urinary corticoid to creatinine ratios are also unaffected.

  DOI：

  10.1111/j.1751-0813.2000.tb10349.x
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 氢溴酸 作用下， 生成 2-hydroxychalcone
  参考文献：
  名称：

  Dufraisse; Chaux, Bulletin de la Societe Chimique de France, 1926, vol. <4>39, p. 451

  摘要：

  DOI：

文献信息

• Room-Temperature Coupling/Decarboxylation Reaction of α-Oxocarboxylates with α-Bromoketones: Solvent-Controlled Regioselectivity for 1,2- and 1,3-Diketones
  作者：Zhen He、Xiaotian Qi、Zhijie She、Yinsong Zhao、Shiqing Li、Junbin Tang、Ge Gao、Yu Lan、Jingsong You

  DOI：10.1021/acs.joc.6b02575

  日期：2017.2.3

  A transition-metal-free and room-temperature coupling/decarboxylation reaction between α-oxocarboxylates and α-bromoketones is reported herein. It represents the first mild and regioselective synthesis of either 1,2- or 1,3-diketones from the same starting materials. Notably, the regioselectivity is simply controlled by solvents. The preliminary experimental data and DFT calculations suggest sequential

  本文报道了α-氧代羧酸盐和α-溴代酮之间的无过渡金属和室温的偶联/脱羧反应。它代表了从相同原料中首次合成1,2-或1,3-二酮的轻度和区域选择性合成。值得注意的是，区域选择性简单地由溶剂控制。初步的实验数据和DFT计算表明，在一锅中依次进行Darzens型偶联，碱水解，KOH促进的环氧乙烷开口和脱羧反应。该方法对于合成α，β-环氧-γ-丁内酯和姜黄素是有效的。
• Synthetic Methodology, Spectral Elucidation, and Antioxidative Properties of Benzothianes and Their Sulfones
  作者：Vibha Gautam、Meenakshi Sharma、Meenakshi Panwar、Naveen Gautam、Ashok Kumar、I. K. Sharma、D. C. Gautam

  DOI：10.1080/10426500802704225

  日期：2009.10.30

  4-benzothiazines. 4H-1,4-benzothiazines have been prepared by the condensation and oxidative cyclization of substituted 2-aminobenzenethiol with β-diketones/β-ketoesters in dimethyl sulfoxide and with the oxidation of 4H-1,4-benzothiazines by 30% hydrogen peroxide in glacial acetic acid, which results in the formation of 4H-1,4-benzothiazine sulfones. The compounds were evaluated for their antioxidative properties

  本文反映了 4H-1,4-苯并噻嗪的合成策略和光谱研究。4H-1,4-苯并噻嗪是通过取代的 2-氨基苯硫醇与 β-二酮/β-酮酯在二甲亚砜中的缩合和氧化环化，以及在 30% 过氧化氢中氧化 4H-1,4-苯并噻嗪制备的。冰醋酸，导致形成 4H-1,4-苯并噻嗪砜。通过对瑞士白化小鼠的体外和体内研究，评估了这些化合物的抗氧化特性。化合物的结构归属是在光谱数据和元素分析的基础上进行的。
• Dufraisse; Moureu, Bulletin de la Societe Chimique de France, 1927, vol. <4> 41, p. 461,468, 471
  作者：Dufraisse、Moureu

  DOI：——

  日期：——
• 121. αβ-Diphenylpropaldehyde
  作者：Harold Burton、C. W. Shoppee

  DOI：10.1039/jr9370000546

  日期：——
• Dufraisse; Moureu, Bulletin de la Societe Chimique de France, 1927, vol. <4> 41, p. 860
  作者：Dufraisse、Moureu

  DOI：——

  日期：——