(E)-3-benzo[1,3]dioxol-5-yl-1-cyclopropylpropen-1-one | 56105-29-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-benzo[1,3]dioxol-5-yl-1-cyclopropylpropen-1-one
• 英文别名: 2-(3,4-methylenedioxyphenyl)vinyl cyclopropyl ketone；(E)-3-(1,3-benzodioxol-5-yl)-1-cyclopropylprop-2-en-1-one
• CAS: 56105-29-4
• 化学式: C₁₃H₁₂O₃
• 分子量: 216.236
• InChiKey: NWDSUOFLOXFSEW-ORCRQEGFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  胡椒醛 、 环丙甲基酮 生成 (E)-3-benzo[1,3]dioxol-5-yl-1-cyclopropylpropen-1-one
  参考文献：
  名称：

  Aryl substituted diketones

  摘要：

  芳基取代的二酮和酮酯，可作为抗病毒剂和杀虫剂使用，通过将芳基烷基或芳基烯基碘化物与适当的二酮或酮酯的金属盐反应制备而成。

  公开号：

  US04171378A1

文献信息

• Dialkylaminophenylethyl (or vinyl) cyclopropyl carbinols
  申请人：Sterling Drug Inc.

  公开号：US04166074A1

  公开（公告）日：1979-08-28

  Aryl substituted diketones and keto-esters, useful as antiviral agents and insecticides, are prepared by reacting an arylalkyl or arylalkenyl iodide with a metal salt of the appropriate diketone or keto-ester. The intermediate iodides are prepared by condensing a methyl cyclopropyl ketone with an aromatic aldehyde to give an arylvinyl cyclopropyl ketone, reducing the latter to an arylethyl cyclopropyl carbinol or arylvinyl cyclopropyl carbinol, treating the carbinol with phosphorus tribromide and then with zinc bromide to give an arylalkyl or arylalkenyl bromide, and then replacing the bromine atom by iodine. The invention herein claimed relates to intermediate arylethyl cyclopropyl carbinols and arylvinyl cyclopropyl carbinols wherein aryl is phenyl substituted by dialkylamino.

  芳基取代的二酮和酮酯，作为抗病毒剂和杀虫剂有用，通过将芳基烷基或芳基烯基碘化物与适当的二酮或酮酯的金属盐反应制备。中间碘化物通过将甲基环丙酮与芳香醛缩合以得到芳基乙烯基环丙酮，将后者还原为芳基乙基环丙醇或芳基乙烯基环丙醇，将环丙醇与三溴化磷处理，然后与溴化锌处理以得到芳基烷基或芳基烯基溴化物，然后将溴原子替换为碘。本发明涉及中间芳基乙基环丙醇和芳基乙烯基环丙醇，其中芳基是由二烷基氨基取代的苯基。
• Methylenedioxyphenyl substituted aliphatic diketones
  申请人：Sterling Drug, Inc.

  公开号：US04093736A1

  公开（公告）日：1978-06-06

  Aryl substituted diketones and keto-esters, useful as antiviral agents and insecticides, are prepared by reacting an arylalkyl or arylalkenyl iodide with a metal salt of the appropriate diketone or keto-ester.

  芳基取代的二酮和酮酯，可用作抗病毒剂和杀虫剂，通过将芳基烷基或芳基烯基碘化物与适当的二酮或酮酯的金属盐反应制备。
• Aryl substituted ketones
  申请人：Sterling Drug Inc.

  公开号：US04125541A1

  公开（公告）日：1978-11-14

  Aryl substituted tertiary carbinols, useful as antiviral agents and insecticides, are prepared by reacting the Grignard reagent derived from an arylalkyl or arylalkenyl iodide with a dialkyl ketone or an alkyl alkenyl ketone; or by reacting an arylalkyl or arylalkenyl ketone with an alkyl- or alkenylmagnesium halide.

  芳基取代的三级碳醇，可用作抗病毒剂和杀虫剂，通过将从芳基烷基或芳基烯基碘化物衍生的格氏试剂与二烷基酮或烷烯基酮反应来制备；或通过将芳基烷基或芳基烯基酮与烷基或烯基镁卤化物反应来制备。
• COMPOUNDS AND COMPOSITIONS FOR NEMATODE TREATMENT
  申请人：IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

  公开号：US20210298295A1

  公开（公告）日：2021-09-30

  Disclosed herein are compounds and compositions for nematode treatment. In particular, disclosed are compounds of formula (I), a method of treating a plant or a growing media for a nematode with compounds of formula (II), compositions, and methods of use.

  本文披露了用于线虫治疗的化合物和组合物。具体而言，披露了公式（I）的化合物，以及使用公式（II）的化合物治疗植物或生长介质中的线虫的方法、组合物和使用方法。
• An efficient direct-aldol addition of methyl ketones with aldehydes promoted by MgI2 etherate
  作者：Yingshuai Liu、Hangzhou Shen、Xingxian Zhang

  DOI：10.1515/mgmc-2012-0029

  日期：2012.1.1

  Direct aldol addition of ketones with aromatic aldehydes and vinyl aldehyde was carried out efficiently in the presence of MgI2 etherate and Et3N using untreated reagent grade CH2Cl2 under atmospheric conditions in a mild, efficient and highly chemoselective manner. Iodide counterion and non-coordinating reaction media (i.e., CH2Cl2) are among the critical factors for the unique reactivity of this reaction system.