pentyl 4-oxopentyl ether | 5894-83-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: pentyl 4-oxopentyl ether
• 英文别名: 5-pentyloxypentan-2-one；5-pentoxypentan-2-one
• CAS: 5894-83-7
• 化学式: C₁₀H₂₀O₂
• 分子量: 172.268
• InChiKey: PIZSYFVWYGGVIF-UHFFFAOYSA-N

物化性质

• 沸点：
  132-134 °C(Press: 12 Torr)
• 密度：
  0.874±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环丙甲基酮 、 戊醇 在 copper(ll) bromide 作用下， 以 水 为溶剂， 反应 10.0h， 以47%的产率得到pentyl 4-oxopentyl ether
  参考文献：
  名称：

  摘要：

  The possibility of the cleavage of the C-C bond in acetylcyclopropane (ACP) under the action of water or alcohols in the presence of copper or palladium salts was demonstrated for the first time. At 175-180 degreesC, the reactions proceeded regioselectively with the cleavage of the C(1)-C(2) bond in the cyclopropane ring. The reaction of ACP with water afforded 5-hydroxypentan-2-one, bis(3-acetylpropyl) ether, and furan compounds, whereas the reactions with alcohols proceeded selectively to form 5-alkoxypentan-2-ones. The yields of the latter depend on the nature and structure of the alcohol, the maximum values (98%) being achieved in the case of primary alcohols.

  DOI：

  10.1023/a:1014010907818

文献信息

• Yoneda, Norihiko; Kiuchi, Takashi; Fukuhara, Tsuyoshi, Chemistry Letters, 1984, p. 1617 - 1618
  作者：Yoneda, Norihiko、Kiuchi, Takashi、Fukuhara, Tsuyoshi、Suzuki, Akira、Olah, George A.

  DOI：——

  日期：——
• YONEDA, NORIHIKO;KIUCHI, TAKASHI;FUKUHARA, TSUYOSHI;SUZUKI, AKIRA;OLAH, G+, CHEM. LETT., 1984, N 9, 1617-1618
  作者：YONEDA, NORIHIKO、KIUCHI, TAKASHI、FUKUHARA, TSUYOSHI、SUZUKI, AKIRA、OLAH, G+

  DOI：——

  日期：——
• [EN] CEREBLON PROTEIN DEGRADATION INDUCING COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER, CONTAINING SAME AS ACTIVE INGREDIENT<br/>[FR] COMPOSÉ INDUISANT LA DÉGRADATION DE LA PROTÉINE CÉRÉBLON, PROCÉDÉ DE PRÉPARATION ASSOCIÉ, ET COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DU CANCER LE CONTENANT EN TANT QUE PRINCIPE ACTIF<br/>[KO] 세레브론 단백질의 분해 유도 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
  申请人：KOREA RES INST CHEMICAL TECH

  公开号：WO2019078522A1

  公开（公告）日：2019-04-25

  본 발명은 세레브론 단백질의 분해 유도 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 A-Linker-A 또는 A-Linker-B로 표시되는 신규 화합물은 세레브론을 우수하게 저해하거나 분해시킬 수 있는 바, 이를 유효성분으로 함유하여 세레브론 관련 질환, 바람직하게 세레브론을 저해 또는 분해하는 것으로부터 치료, 예방 또는 개선과 같은 효과가 달성될 수 있는 질환, 예를 들어, 암, 자가면역질환, 또는 대사질환의 예방 또는 치료용 약학적 조성물로서 유용한 효과가 있다.
• ——
  作者：U. M. Dzhemilev、R. I. Khusnutdinov、A. M. Atnabaeva、Z. S. Muslimov、R. I. Parfenova、Yu. V. Tomilov

  DOI：10.1023/a:1014010907818

  日期：——

  The possibility of the cleavage of the C-C bond in acetylcyclopropane (ACP) under the action of water or alcohols in the presence of copper or palladium salts was demonstrated for the first time. At 175-180 degreesC, the reactions proceeded regioselectively with the cleavage of the C(1)-C(2) bond in the cyclopropane ring. The reaction of ACP with water afforded 5-hydroxypentan-2-one, bis(3-acetylpropyl) ether, and furan compounds, whereas the reactions with alcohols proceeded selectively to form 5-alkoxypentan-2-ones. The yields of the latter depend on the nature and structure of the alcohol, the maximum values (98%) being achieved in the case of primary alcohols.