1-hydroxy-1,2,3-triazole | 116932-70-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-hydroxy-1,2,3-triazole
• 英文别名: 1-hydroxytriazole；N-hydroxytriazole；hydroxy-triazole；1-hydroxy-1,2,3 triazole；hydroxy triazole；triazolylalcohol
• CAS: 116932-70-8
• 化学式: C₂H₃N₃O
• 分子量: 85.0653
• InChiKey: FQKFPGMGQXQHLP-UHFFFAOYSA-N

物化性质

• 沸点：
  288.5±23.0 °C(Predicted)
• 密度：
  1.60±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-二乙基氯甲酰胺 、 1-hydroxy-1,2,3-triazole 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以92%的产率得到triazol-1-yl N,N-diethylcarbamate
  参考文献：
  名称：

  Synthesis of 5-Substituted 1-Hydroxy-1,2,3-triazoles through Directed Lithiation of 1-(Benzyloxy)-1,2,3-triazole

  摘要：

  1-(Benzyloxy)-1,2,3-triazole, prepared by selective benzylation of 1-hydroxy-1,2,3-triazole or by oxidative cyclization of 2-hydrazonoglyoxal O-benzyloxime, was metalated exclusively at the 5-position upon treatment with n-butyllithium. The anion formed reacted with a series of electrophiles. In this way carbon, halogen, sulfur, silicon, and tin substituents could be introduced at the 5-position. Subsequent removal of the benzyl group by palladium-catalyzed hydrogenolysis or by treatment with hydrochloric acid afforded the corresponding 5-substituted 1-hydroxy-1,2,3-triazoles.

  DOI：

  10.1021/jo971313o
• 作为产物：
  描述：

  2-benzyl-1,2,3-triazole 1-oxide 在 氢溴酸 作用下， 反应 3.0h， 以97%的产率得到1-hydroxy-1,2,3-triazole
  参考文献：
  名称：

  Preparation of 1-Hydroxypyrazoles and 1-Hydroxy-1,2,3-triazoles by Dealkylation of Pyrazole and Triazole N-Oxides.

  摘要：

  1-Hydroxypyrazoles were obtained from 2-benzylpyrazole I-oxides by debenzylation with iodotrimethylsilane. 1-Hydroxy-1,2,3-triazoles were achieved from 2-benzyltriazole 1-oxides by debenzylation effected with cone. hydrobromic acid or from 2- or 3-p-methoxybenzyltriazole 1-oxides by de-p-methoxybenzylation accomplished by treatment with cone. sulfuric acid. 1-Methoxy-1,2,3-triazole was obtained by de-p-methoxybenzylation of 1-methoxy-3-p-methoxybenzyl-1,2,3-triazolium tetrafluoroborate accomplished by treatment with cone. sulfuric acid. 1-Hydroxypyrazole was selectively N-benzylated in absence of base to give 2-benzylpyrazole 1-oxide which, upon selective substitution at the 3-position and subsequent debenzylation, produced 3-substituted 1-hydroxypyrazole.

  DOI：

  10.3891/acta.chem.scand.50-0549
• 作为试剂：
  描述：

  4-氨基-1,2,4-三氮唑 、 1-[3-[4-[[(2-Cyanopyrimidin-4-yl)-(2,2-dimethylpropyl)amino]methyl]phenyl]prop-2-ynyl]piperidine-4-carboxylic acid 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 1-hydroxy-1,2,3-triazole 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以56%的产率得到1-[3-(4-{[(2-cyano-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-amino]-methyl}-phenyl)-prop-2-ynyl]-piperidine-4-carboxylic acid [1,2,4] triazol-4-ylamide
  参考文献：
  名称：

  [EN] HETEREOARYL NITRILE DERIVATIVES
  [FR] DERIVES D'HETEREOARYLE NITRILE

  摘要：

  该发明提供了式（I）的化合物或其药用可接受的盐或酯，其中符号的含义如定义，这些化合物是卡特普辛K的抑制剂，并在药学上用于治疗卡特普辛K参与的疾病和医疗状况，例如各种疾病，包括炎症、类风湿关节炎、骨关节炎、骨质疏松症和肿瘤。

  公开号：

  WO2004020441A1

文献信息

• Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
  申请人：——

  公开号：US20030166644A1

  公开（公告）日：2003-09-04

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物抑制激素敏感性脂肪酶，包括这些化合物的药物组合物，使用这些化合物和组合物的治疗方法，以及新化合物。目前的化合物是激素敏感性脂肪酶的抑制剂，可能在治疗和/或预防需要降低激素敏感性脂肪酶活性的医学疾病中有用。
• Use of compounds for decreasing activity of hormone-sensitive
  申请人：——

  公开号：US20030166690A1

  公开（公告）日：2003-09-04

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物来抑制激素敏感性脂肪酶，包括这些化合物的制药组合物，使用这些化合物和组合物的治疗方法，以及新颖的化合物。这些化合物是激素敏感性脂肪酶的抑制剂，可用于治疗和/或预防需要降低激素敏感性脂肪酶活性的医学疾病。
• Derivatives of 1-hydroxy-1,2,4-triazole and fungicides and growth
  申请人：BASF Aktiengesellschaft

  公开号：US05081142A1

  公开（公告）日：1992-01-14

  Compounds of the formula I ##STR1## where Ar is unsubstituted or substituted phenyl, pyridyl, thienyl or napthyl, R.sup.1 is hydrogen or CN, R.sup.2 is unsubstituted or substituted aryl, hetaryl, alkyl or cycloalkyl, or is unsubstituted or substituted alkenyl or alkynyl, x is CH.sub.2, O or S and n is 0 or 1, their plant-tolerated acid addition salts and metal complexes, and fungicides and growth regulators containing these compounds.

  化合物的公式为I ##STR1## 其中Ar为未取代或取代的苯基，吡啶基，噻吩基或萘基，R.sup.1为氢或CN，R.sup.2为未取代或取代的芳基，杂环芳基，烷基或环烷基，或未取代或取代的烯基或炔基，x为CH.sub.2，O或S，n为0或1，它们的植物耐受性酸盐和金属配合物，以及含有这些化合物的杀菌剂和生长调节剂。
• BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERIDINE OR PIPERAZINE DERIVATIVES AND PREPARATION METHODS AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Zhou Yan

  公开号：US20160009703A1

  公开（公告）日：2016-01-14

  The present invention relates to the compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R 1 , R 2 , X, Y, A and B are defined in the description. Also disclosed in the present invention are the methods for preparing the compounds of formula (I) or pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising the compounds of formula (I) or pharmaceutically acceptable salts thereof.

  本发明涉及公式（I）的化合物或其药学上可接受的盐：其中R1、R2、X、Y、A和B在说明中有定义。本发明还公开了制备公式（I）的化合物或其药学上可接受的盐的方法，以及包含公式（I）的化合物或其药学上可接受的盐的药物组合物。
• Use of compounds for decreasing activity of hormone-sensitive lipase
  申请人：Nero Nordisk A/S

  公开号：US07067517B2

  公开（公告）日：2006-06-27

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物抑制荷尔蒙敏感性脂肪酶，包括这些化合物的制药组合物，使用这些化合物和组合物的治疗方法，以及新型化合物。这些化合物是荷尔蒙敏感性脂肪酶的抑制剂，可能在需要降低荷尔蒙敏感性脂肪酶活性的医疗障碍的治疗和/或预防中有用。