N-vinyl-2-methoxyacetamide | 862658-21-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-vinyl-2-methoxyacetamide
• 英文别名: N-ethenyl-2-methoxyacetamide
• CAS: 862658-21-7
• 化学式: C₅H₉NO₂
• mdl: MFCD19220616
• 分子量: 115.132
• InChiKey: XTCQONKMXWPSDZ-UHFFFAOYSA-N

物化性质

• 沸点：
  239.5±32.0 °C(Predicted)
• 密度：
  0.971±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-vinyl-2-methoxyacetamide 在 1,1'-双(二苯基膦)二茂铁 、 Wilkinson's catalyst 、 tris(dibenzylideneacetone)dipalladium (0) 氢气 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 1.5h， 生成 N-(1-naphthalen-2-ylethyl)-2-methoxyacetamide
  参考文献：
  名称：

  Fast and Regioselective Heck Couplings with N-Acyl-N-vinylamine Derivatives

  摘要：

  Highly regioselective Heck couplings of aryl triflates with N-acyl-N-vinylamines lacking an N-alkyl substituent were achieved with reaction times of approximately 1 h in yields ranging from 62 to 98% using 1.5 mol % of Pd-2(dba)(3), 3 mol % of DPPF, and diethylisopropylamine in dioxane. The efficiency of these cross-couplings were studied with several N-vinylamides and an example each of an N-vinylcarbamate and an N-vinylurea. The Heck coupling products easily underwent acidic hydrolysis to the corresponding aryl methyl ketone or in situ hydrogenation in the presence of (Ph3P)(3)RhCl under a hydrogen atmosphere to provide the N-acyl derivatives of pharmaceutically relevant benzylic amines. The coupling of a vinyl triflate and more interestingly a vinyl tosylate to N-vinyl acetamide was also studied affording a 2-acylamino-1,3-butadiene with the same high regioselectivity in preference for the alpha-isomer. This result suggests that Heck couplings of electron-rich alkenes with vinyl tosylates also follow a cationic pathway.

  DOI：

  10.1021/jo050669u
• 作为产物：
  描述：

  碘化乙烯 、 2-甲氧基-乙酰胺 在 copper(l) iodide 、 caesium carbonate 、 N,N'-二甲基乙二胺 作用下， 以 四氢呋喃 为溶剂， 反应 17.0h， 以56%的产率得到N-vinyl-2-methoxyacetamide
  参考文献：
  名称：

  Fast and Regioselective Heck Couplings with N-Acyl-N-vinylamine Derivatives

  摘要：

  Highly regioselective Heck couplings of aryl triflates with N-acyl-N-vinylamines lacking an N-alkyl substituent were achieved with reaction times of approximately 1 h in yields ranging from 62 to 98% using 1.5 mol % of Pd-2(dba)(3), 3 mol % of DPPF, and diethylisopropylamine in dioxane. The efficiency of these cross-couplings were studied with several N-vinylamides and an example each of an N-vinylcarbamate and an N-vinylurea. The Heck coupling products easily underwent acidic hydrolysis to the corresponding aryl methyl ketone or in situ hydrogenation in the presence of (Ph3P)(3)RhCl under a hydrogen atmosphere to provide the N-acyl derivatives of pharmaceutically relevant benzylic amines. The coupling of a vinyl triflate and more interestingly a vinyl tosylate to N-vinyl acetamide was also studied affording a 2-acylamino-1,3-butadiene with the same high regioselectivity in preference for the alpha-isomer. This result suggests that Heck couplings of electron-rich alkenes with vinyl tosylates also follow a cationic pathway.

  DOI：

  10.1021/jo050669u

文献信息

• Regioselective Heck Couplings of α,<i>β</i>-Unsaturated Tosylates and Mesylates with Electron-Rich Olefins
  作者：Anders Lindhardt Hansen、Troels Skrydstrup

  DOI：10.1021/ol052136d

  日期：2005.12.1

  [chemical reaction: see text]. Highly regioselective Heck couplings of alpha,beta-unsaturated tosylate and mesylate derivatives with N-acyl N-vinylamines and vinyl ethers were achieved. Several 2-alkoxy-1,3-dienes and 2-acylamino-1,3-butadienes were synthesized in good yields using 1.5 mol % of Pd2(dba)3, 3 mol % of DPPF, and diisopropylethylamine in dioxane. When working with alpha,beta-unsaturated

  [化学反应：见正文]。实现了α，β-不饱和甲苯磺酸酯和甲磺酸酯衍生物与N-酰基N-乙烯基胺和乙烯基醚的高度区域选择性Heck偶联。使用1.5 mol％的Pd2（dba）3、3 mol％的DPPF和二异丙基乙胺的二恶烷溶液，可以高收率合成数种2-烷氧基-1,3-二烯和2-酰基氨基-1,3-丁二烯。当使用α，β-不饱和酮和酯时，该方法为使用三氟甲磺酸亲电子试剂的类似偶联提供了一种成本更低的替代方法。