5-bromo-2-(5-bromo-2-propoxyphenyl)-6-isopropylpyrimidin-4(3H)-one | 1449771-77-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-bromo-2-(5-bromo-2-propoxyphenyl)-6-isopropylpyrimidin-4(3H)-one
• 英文别名: 5-bromo-2-(5-bromo-2-propoxyphenyl)-4-propan-2-yl-1H-pyrimidin-6-one
• CAS: 1449771-77-0
• 化学式: C₁₆H₁₈Br₂N₂O₂
• 分子量: 430.139
• InChiKey: LXLXHXXDEPBKOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-bromo-2-(5-bromo-2-propoxyphenyl)-6-isopropylpyrimidin-4(3H)-one 在 溴 、 palladium diacetate 、 三乙胺 、 1,4-双(二苯基膦)丁烷 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 43.0h， 生成 5-bromo-2-(5-(2-bromoacetyl)-2-propoxyphenyl)-6-isopropylpyrimidin-4(3H)-one
  参考文献：
  名称：

  Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5

  摘要：

  The substituents both at the 6-position of the 5-bromopyrimidinone ring and at the 5'-position of the phenyl ring of 5-bromopyrimidin-4(3H)-ones were explored. 5-Bromo-6-isopropyl-2-(2-propoxyphenyl)pyrimidin-4(3H)-one was identified as a new scaffold for potent PDE5 inhibitors. The crystal structures of PDE5/2e and PDE5/10a complexes provided a structural basis for the inhibition of 5-bromopyrimidinones to PDE5. In addition, it was also found that there is a great tolerance for the substitution at the 5'-position of the phenyl ring of 5-bormopyrimidinones and the resulted compound 13a has the highest inhibition activity to PDE5 (IC50, 1.7 nM). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.06.062
• 作为产物：
  描述：

  5-bromo-6-isopropyl-2-(2-propoxyphenyl)pyrimidin-4(3H)-one 在 溴 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 以76%的产率得到5-bromo-2-(5-bromo-2-propoxyphenyl)-6-isopropylpyrimidin-4(3H)-one
  参考文献：
  名称：

  Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5

  摘要：

  The substituents both at the 6-position of the 5-bromopyrimidinone ring and at the 5'-position of the phenyl ring of 5-bromopyrimidin-4(3H)-ones were explored. 5-Bromo-6-isopropyl-2-(2-propoxyphenyl)pyrimidin-4(3H)-one was identified as a new scaffold for potent PDE5 inhibitors. The crystal structures of PDE5/2e and PDE5/10a complexes provided a structural basis for the inhibition of 5-bromopyrimidinones to PDE5. In addition, it was also found that there is a great tolerance for the substitution at the 5'-position of the phenyl ring of 5-bormopyrimidinones and the resulted compound 13a has the highest inhibition activity to PDE5 (IC50, 1.7 nM). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.06.062

文献信息

• Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5
  作者：Xudong Gong、Guan Wang、Jing Ren、Zheng Liu、Zhen Wang、Tiantian Chen、Xiaojun Yang、Xiangrui Jiang、Jingshan Shen、Hualiang Jiang、Haji Akber Aisa、Yechun Xu、Jianfeng Li

  DOI：10.1016/j.bmcl.2013.06.062

  日期：2013.9

  The substituents both at the 6-position of the 5-bromopyrimidinone ring and at the 5'-position of the phenyl ring of 5-bromopyrimidin-4(3H)-ones were explored. 5-Bromo-6-isopropyl-2-(2-propoxyphenyl)pyrimidin-4(3H)-one was identified as a new scaffold for potent PDE5 inhibitors. The crystal structures of PDE5/2e and PDE5/10a complexes provided a structural basis for the inhibition of 5-bromopyrimidinones to PDE5. In addition, it was also found that there is a great tolerance for the substitution at the 5'-position of the phenyl ring of 5-bormopyrimidinones and the resulted compound 13a has the highest inhibition activity to PDE5 (IC50, 1.7 nM). (C) 2013 Elsevier Ltd. All rights reserved.