(S)-1-tert-Butoxy-butan-2-ol | 136656-77-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-1-tert-Butoxy-butan-2-ol
• 英文别名: 2-Butanol, 1-(1,1-dimethylethoxy)-, (S)-；(2S)-1-[(2-methylpropan-2-yl)oxy]butan-2-ol
• CAS: 136656-77-4
• 化学式: C₈H₁₈O₂
• 分子量: 146.23
• InChiKey: QTXZTRIEQIRTAK-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-tert-butoxy-2-butanol 以 various solvent(s) 为溶剂， 生成 Acetic acid (R)-1-tert-butoxymethyl-propyl ester 、 (S)-1-tert-Butoxy-butan-2-ol
  参考文献：
  名称：

  对映体纯环氧乙烷的简便化学酶促途径：生物活性化合物的组成部分

  摘要：

  对映体纯积木（[R ）-和（小号） - 1 - 4通过对映体选择性，酶水解和通过酰基转移制备两者，并随后转化为相应的对映体纯的环氧乙烷（[R ） -和（小号） - 7和8。

  DOI：

  10.1039/c39910001064

文献信息

• NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA
  申请人：NOVARTIS AG

  公开号：US20180111932A1

  公开（公告）日：2018-04-26

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R 1 , R 3 -R 6 , X 2 and X 3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了化合物(I)或其药学上可接受的盐；其中R1、R3-R6、X2和X3如本文所定义，一种制造本发明化合物的方法，以及其治疗用途。本发明还提供了药理活性剂的组合和药物组成。
• BISPHENOL COMPOUNDS AND METHODS FOR THEIR USE
  申请人：Andersen Raymond John

  公开号：US20140248263A1

  公开（公告）日：2014-09-04

  Compounds having a structure of Formula I: wherein G, a, Q, L 2 , R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.

  提供具有公式I结构的化合物，其中G，a，Q，L2，R1，R2，R3，R4，R5和R6的定义如本文所述。提供了这种化合物用于治疗各种适应症，包括前列腺癌以及涉及这种化合物的治疗方法。
• BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS
  申请人：Sadar Marianne D.

  公开号：US20130131167A1

  公开（公告）日：2013-05-23

  This invention provides bisphenol derivatives having a structure of formula 1. Said compounds are modulators of the androgen receptor activity and are useful in the treatment of various diseases, including prostate cancer, breast cancer, ovarian cancer, endometrial cancer, acne, ovarian cysts, polycystic ovarian disease, age-related macular degeneration, precocious puberty, hirsutism and hair loss.
• BISPHENOL DERIVATIVE THERAPEUTICS AND METHODS FOR THEIR USE
  申请人：Sadar Marianne D.

  公开号：US20130109758A1

  公开（公告）日：2013-05-02

  This invention provides compounds having a structure of Formula (I). Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
• US9388112B2
  申请人：——

  公开号：US9388112B2

  公开（公告）日：2016-07-12