3-(m-methoxyphenyl)butanol | 4207-89-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(m-methoxyphenyl)butanol
• 英文别名: 3-(3-Methoxy-phenyl)-butanol-1；3-(m-Methoxyphenyl)-butan-1-ol；3-(3-methoxyphenyl)-1-butanol；dl-3-(m-methoxyphenyl)butanol；3-(3-methoxyphenyl)butan-1-ol
• CAS: 4207-89-0
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: VNQCJHNRZUAISK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(m-methoxyphenyl)butanol 在 咪唑 、 sodium azide 、 碘 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 1-(3-azido-1-methylpropyl)-3-methoxybenzene
  参考文献：
  名称：

  Hypervalent Iodine(III)-induced Intramolecular Cyclization Reaction of Substituted Phenol Ethers with an Alkyl Azido Side-chain: A Novel and Efficient Synthesis of Quinone Imine Derivatives.

  摘要：

  利用高价碘(III)试剂，苯基碘(III)双(三氟乙酸酯)(PIFA)和三甲基硅基三氟甲磺酸酯(TMSOTf)的组合，已经开发出了一种新颖且高效的合成方法，用于从带有烷基叠氮侧链的取代苯酚醚(1a-k)合成醌亚胺缩酮(2a-j)和醌亚胺(4a-h)。

  DOI：

  10.1248/cpb.47.241
• 作为产物：
  描述：

  3-甲氧基苯乙酮 在 palladium on activated charcoal lithium aluminium tetrahydride 、 正丁基锂 、 氢气 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 3-(m-methoxyphenyl)butanol
  参考文献：
  名称：

  Hypervalent Iodine(III)-induced Intramolecular Cyclization Reaction of Substituted Phenol Ethers with an Alkyl Azido Side-chain: A Novel and Efficient Synthesis of Quinone Imine Derivatives.

  摘要：

  利用高价碘(III)试剂，苯基碘(III)双(三氟乙酸酯)(PIFA)和三甲基硅基三氟甲磺酸酯(TMSOTf)的组合，已经开发出了一种新颖且高效的合成方法，用于从带有烷基叠氮侧链的取代苯酚醚(1a-k)合成醌亚胺缩酮(2a-j)和醌亚胺(4a-h)。

  DOI：

  10.1248/cpb.47.241

文献信息

• 3-[2-Hydroxy-4-(substituted)phenyl]-cycloalkanol analgesic agents
  申请人：Pfizer Inc.

  公开号：US04306097A1

  公开（公告）日：1981-12-15

  Cycloalkanones, cycloalkanols and unsaturated analogs thereof, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.

  环烷酮、环烷醇及其不饱和类似物，每个在3位上具有一个2-羟基-4-取代苯基团，其中4位取代基是可以在链中具有氧原子的烷基，或者可以在烷基链中具有氧原子的芳基烷基，它们用于药理学和药用目的，以及其中间体和制备过程。
• Hydroxyalkyl and oxoalkyl substituted phenols as analgesics and sedatives
  申请人：Pfizer Inc.

  公开号：US04283569A1

  公开（公告）日：1981-08-11

  Compounds useful for pharmacological and medicinal purposes having the formulae ##STR1## wherein R is H, C.sub.1 -C.sub.5 alkanoyl; R.sub.1 is H, benzyl, C.sub.1 -C.sub.5 alkanoyl, P(O)(OH).sub.2, --CO(CH.sub.2).sub.2 COOH or a basic acyl group; each of R.sub.2 and R.sub.4 is H, C.sub.1 -C.sub.6 alkyl, phenyl, pyridyl or (CH.sub.2).sub.y C.sub.6 H.sub.5 ; y is 1-4; R.sub.3 is H or CH.sub.3 ; Z is C.sub.1 -C.sub.13 alkylene or --(alk.sub.1).sub.m --O--(alk.sub.2).sub.n --; each of (alk.sub.1) and (alk.sub.2) is C.sub.1 -C.sub.13 alkylene with the proviso that the summation of carbon atoms in (alk.sub.1) plus (alk.sub.2) is not greater than 13; each of m and n is 0 or 1; and W is H, pyridyl, phenyl, fluorophenyl or chlorophenyl; intermediates therefor and methods for their preparation and use.

  用于药理学和药用目的的化合物，其分子式为##STR1##其中R为H，C.sub.1 -C.sub.5烷酰基；R.sub.1为H，苄基，C.sub.1 -C.sub.5烷酰基，P(O)(OH).sub.2，--CO(CH.sub.2).sub.2 COOH或一种碱性酰基；R.sub.2和R.sub.4中的每一个为H，C.sub.1 -C.sub.6烷基，苯基，吡啶基或(CH.sub.2).sub.y C.sub.6 H.sub.5；y为1-4；R.sub.3为H或CH.sub.3；Z为C.sub.1 -C.sub.13亚烷基或--(alk.sub.1).sub.m--O--(alk.sub.2).sub.n--；(alk.sub.1)和(alk.sub.2)中的每一个为C.sub.1 -C.sub.13亚烷基，但要求(alk.sub.1)加上(alk.sub.2)的碳原子总数不大于13；m和n中的每一个为0或1；W为H，吡啶基，苯基，氟苯基或氯苯基；其中间体以及其制备和使用方法。
• Generality and mechanism of homobenzylic-homoallylic hydrogenolysis of 5-aryl-4,5-dihydro-1,3-dioxepins
  作者：Kiyohiro Samizu、Kunio Ogasawara

  DOI：10.1016/0040-4039(94)80030-8

  日期：1994.10

  Birch reduction of several 5-aryl-4,5-dihydro-1,3-dioxepins gave rise to 3-arylbutanal in moderate to good yields by hydrogenolytic cleavage of the homobenzylic-homoallylic carbonoxygen bond when the benzylic-allylic carbon is tertiary. However, the reaction did not take place when the benzylic-allylic carbon is quaternary. Moreover, the reaction was found to proceed with complete racemization at

  当苄基-烯丙基碳为叔碳时，通过氢解裂解均苄基-均烯丙基碳-氧键，桦木还原几种5-芳基-4,5-二氢-1,3-二氧杂环丁烷可以中等至良好的收率得到3-芳基丁醛。 。但是，当苄基烯丙基碳为季铵盐时，该反应没有发生。此外，发现该反应在苄基烯丙基中心完全消旋地进行，表明涉及同时发生的消除-还原途径。
• 3-[2-Hydroxy-4-(substituted)-phenyl]azacycloalkanes and derivatives
  申请人：Pfizer Inc.

  公开号：US04147872A1

  公开（公告）日：1979-04-03

  Azacycloalkanes, and derivatives thereof, including unsaturated analogs, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.

  Azacycloalkanes，及其衍生物，包括不饱和类似物，每个分子在3位有一个2-羟基-4-取代苯基，其中4位的取代基是烷基，可以有氧原子作为链的一部分，或者是芳基烷基，可以有氧原子作为烷基链的一部分，它们用于药理和医学目的，中间体以及它们的制备方法。
• 3-[2-Hydroxy-4-(substituted)phenyl]azacycloalkanols and derivatives
  申请人：Pfizer Inc.

  公开号：US04387229A1

  公开（公告）日：1983-06-07

  Azacycloalkanes, and derivatives thereof, including unsaturated analogs, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.

  Azacycloalkanes及其衍生物，包括不饱和类似物，每个在3位置具有2-羟基-4-取代苯基基团的化合物，其中4位置取代基是可以作为链的一部分具有氧原子的烷基或可以作为烷基链的一部分具有氧原子的芳基烷基，它们用于药理和医学目的，其中间体和制备它们的过程。