3-[4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl]phenol | 330442-02-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl]phenol
• CAS: 330442-02-9
• 化学式: C₂₃H₂₀N₂O₃
• 分子量: 372.423
• InChiKey: YUZBUXKEJMVALH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间羟基苯甲醛 、 4,4'-二甲氧基苯酚酯 在 ammonium acetate 、 溶剂黄146 作用下， 生成 3-[4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl]phenol
  参考文献：
  名称：

  洛芬衍生物的晶体结构和溶液光谱

  摘要：

  摘要 合成了洛芬(2,4,5-三苯基咪唑)衍生物并测定了其理化性质。介绍了在不同 pH 值和各种溶剂下，洛啡因衍生物在甲醇中的光谱和荧光行为。溶液中观察到的光谱特征是由 NH 氢的特定相互作用决定的。这些类型的相互作用在固态和溶液中都表现出来。介绍和讨论了具有不同结晶溶剂的洛啡因衍生物的晶体和分子结构。在所有溶剂化物中，溶剂分子通过氢键连接主体分子。

  DOI：

  10.1016/j.molstruc.2008.07.003

文献信息

• Zinc (II) [tetra(4-methylphenyl)] Porphyrin: a Novel and Reusable Catalyst for Efficient Synthesis of 2,4,5-trisubstituted Imidazoles Under Ultrasound Irradiation
  作者：Javad Safari、Shiva Dehghan Khalili、Sayed Hossein Banitaba、Hossein Dehghani

  DOI：10.5012/jkcs.2011.55.5.787

  日期：2011.10.20

  An efficient three-component one-step synthesis of 2,4,5-trisubstituted imidazoles by condensation reaction of 1,2-diketones or α-hydroxyketones with aromatic aldehydes and ammonium acetate using Zinc (II) (tetra (4-methylphenyl)) porphyrin as a novel and reusable catalyst under ultrasound irradiation at ambient temperature is described. In this method, α-hydroxyketones as well as 1,2-diketones were

  使用锌（II）（四（4-甲基苯基））使1,2-二酮或α-羟基酮与芳族醛和乙酸铵缩合反应，可有效地三步合成2,4,5-三取代的咪唑描述了在室温下超声辐射下卟啉作为新型可重复使用的催化剂。在这种方法中，α-羟基酮以及1,2-二酮以优异的产率转化为它们相应的2,4,5-三取代的咪唑。
• A highly efficient magnetic solid acid catalyst for synthesis of 2,4,5-trisubstituted imidazoles under ultrasound irradiation
  作者：Javad Safari、Zohre Zarnegar

  DOI：10.1016/j.ultsonch.2012.10.004

  日期：2013.3

  Fe3O4 nanoparticles were prepared by chemical coprecipitation method and subsequently coated with 3-aminopropyltriethoxysilane (APTES) via silanization reaction. Grafting of chlorosulfuric acid on the amino-functionalized Fe3O4 nanoparticles afforded sulfamic acid-functionalized magnetic nanoparticles (SA-MNPs). SA-MNPs was found to be a mild and effective solid acid catalyst for the efficient, one-pot, three-component synthesis of 2,4,5-trisubstituted imidazoles under ultrasound irradiation. This protocol afforded corresponding imidazoles in shorter reaction durations, and in high yields. This green procedure has many obvious advantages compared to those reported in the previous literatures, including avoiding the use of harmful catalysts, easy and quick isolation of the products, excellent yields, short routine, and simplicity of the methodology. (C) 2012 Elsevier B.V. All rights reserved.