galactosamine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: galactosamine
• 英文别名: L-Galaktosamin；2-amino-L-2-deoxy-galactose；l-Galactosamine；(3S,4S,5S,6S)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
• 化学式: C₆H₁₃NO₅
• 分子量: 179.173
• InChiKey: MSWZFWKMSRAUBD-ZZWDRFIYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  116
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  galactosamine 、 C₄₉H₃₈N₈O₈Zn 以 aq. phosphate buffer 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以93%的产率得到C₅₅H₄₉N₉O₁₂Zn
  参考文献：
  名称：

  Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines

  摘要：

  A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy.

  DOI：

  10.1021/acs.orglett.0c02398

文献信息

• [EN] METHOD OF MODIFYING A PEPTIDE<br/>[FR] PROCÉDÉ DE MODIFICATION D'UN PEPTIDE
  申请人：ARROWHEAD PHARMACEUTICALS INC

  公开号：WO2017124066A1

  公开（公告）日：2017-07-20

  Described herein are methods of modifying a peptide with a chemical agent. The peptide may be an amphipathic peptide, such as a melittin-like peptide. The reactants are dissolved in an organic solvent and the reaction is allowed to proceed during sequential additions of a first base and a second base. Reaction in organic solvent with sequential base additions yields greater than 90% modification of both N-terminal and internal primary amine modification.
• Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines
  作者：Clarence T. T. Wong、Jacky C. H. Chu、Summer Y. Y. Ha、Roy C. H. Wong、Gaole Dai、Tsz-Tung Kwong、Chi-Hang Wong、Dennis K. P. Ng

  DOI：10.1021/acs.orglett.0c02398

  日期：2020.9.18

  A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy.