2-氨基-1-(2,4-二氟苯基)乙酮盐酸盐 | 786719-60-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-氨基-1-(2,4-二氟苯基)乙酮盐酸盐
• 中文别名: 2-氨基-2',4'-二氟苯乙酮盐酸盐；2,4-二氟苯乙酰胺盐酸盐
• 英文名称: 2,4-difluorophenacylamine hydrochloride
• 英文别名: 2-amino-1-(2,4-difluorophenyl)ethanone hydrochloride；2-amino-1-(2,4-difluorophenyl)ethan-1-one hydrogen chloride；2-amino-1-(2,4-difluorophenyl)ethanone;hydrochloride
• CAS: 786719-60-6
• 化学式: C₈H₇F₂NO*ClH
• 分子量: 207.607
• InChiKey: IVNYKZOEFAMYSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.53
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  43.1
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2922399090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Amino-2’,4’-difluoroacetophenone, HCl
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Amino-2’,4’-difluoroacetophenone, HCl
CAS number: 786719-60-6

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C8H7F2NO.ClH
Molecular weight: 207.6

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, hydrogen fluoride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-氨基-1-(2,4-二氟苯基)乙酮盐酸盐 在 盐酸 、 碳酸氢钠 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N'-羰基二咪唑 作用下， 以 甲醇 、 乙醇 、 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 4.0h， 生成 5-(4-chlorophenyl)-N-(1-(2,4-difluorophenyl)-3-(1H-imidazole-1-yl)-1-oxopropan-2-yl)thiophene-2-carboxamide
  参考文献：
  名称：

  新型 5-苯基噻吩衍生物的设计、合成和评价作为有效的白色念珠菌杀真菌剂和氟康唑抗性真菌的抗真菌剂

  摘要：

  设计和合成了一系列具有新结构的 5-苯基噻吩衍生物，以对抗日益增加的易感和耐药真菌感染的发病率。合成化合物的抗真菌活性针对 7 种敏感菌株和 6 种氟康唑耐药菌株进行了评估。特别令人鼓舞的是，化合物17b和17f对所有测试菌株都显示出显着的抗真菌活性。此外，有效的化合物17b和17f可以防止真菌生物膜的形成，并且17f显示出令人满意的杀菌活性。初步的机理研究表明，化合物17f的强效抗真菌活性源于对白色念珠菌CYP51 的抑制。此外，化合物17b和17f对哺乳动物 A549、MCF-7 和 THLE-2 细胞几乎无毒。这些结果强烈表明化合物17b和17f作为新型抗真菌药物很有前景。

  DOI：

  10.1016/j.ejmech.2021.113740
• 作为产物：
  描述：

  2-溴-2',4'-二氟苯乙酮 在 乌洛托品 、 盐酸 作用下， 以 氯仿 、 乙醇 、 水 为溶剂， 反应 4.0h， 生成 2-氨基-1-(2,4-二氟苯基)乙酮盐酸盐
  参考文献：
  名称：

  苯二氮卓类脑穿透性PARP-1抑制剂的设计与合成

  摘要：

  摘要 聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂在癌症治疗中起着至关重要的作用。然而，大多数批准的 PARP 抑制剂不能穿过血脑屏障，从而限制了它们在中枢神经系统中的应用。在这里，设计并合成了 55 种苯二氮卓类药物来筛选脑穿透性 PARP-1 抑制剂。评估所有目标化合物的 PARP-1 抑制活性，并选择具有更好活性的化合物进行进一步的体外测定。其中，化合物H34、H42、H48和H52对乳腺癌细胞表现出可接受的抑制作用。此外，计算预测与体外渗透性测定和体内证明我们合成的苯二氮卓类PARP-1抑制剂具有脑渗透性。化合物H52表现出比 Rucaparib 高 40 倍的 B/P 比率，将被选择用于开发其在神经退行性疾病中的潜在用途。我们的研究为开发脑穿透性 PARP-1 抑制剂提供了潜在的先导化合物和设计策略。 强调 结构融合用于筛选脑穿透 PARP-1 抑制剂。 评估了 55 种苯二氮卓类药物的

  DOI：

  10.1080/14756366.2022.2053524

文献信息

• [EN] METALLOENZYME INHIBITOR COMPOUNDS<br/>[FR] COMPOSÉS INHIBITEURS DE MÉTALLOENZYMES
  申请人：VPS 3 INC

  公开号：WO2018165520A1

  公开（公告）日：2018-09-13

  Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

  提供具有HDAC6调节活性的化合物，以及通过HDAC6介导的治疗疾病、疾病或症状的方法。
• [EN] PIPERIDINE CXCR7 RECEPTOR MODULATORS<br/>[FR] MODULATEURS DU RÉCEPTEUR DE CXCR7 PIPÉRIDINE
  申请人：IDORSIA PHARMACEUTICALS LTD

  公开号：WO2018019929A1

  公开（公告）日：2018-02-01

  The present invention relates to piperidine derivatives of formula (I) wherein Ar1, Ar2, RAr1, R1, R2, and R3 are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

  本发明涉及式(I)的哌啶衍生物，其中Ar1、Ar2、RAr1、R1、R2和R3如描述中所述，它们的制备，其药学上可接受的盐，以及它们作为药物的用途，含有一个或多个式(I)化合物的药物组合物，特别是它们作为CXCR7受体调节剂的用途。
• [EN] ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF<br/>[FR] PYRROLO-PYRIDINONES SUBSTITUÉES PAR ARYLE ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：BAYER AG

  公开号：WO2022023339A1

  公开（公告）日：2022-02-03

  Compounds of formula (I), processes for their production and their use as pharmaceuticals.

  化合物的化学式（I），其生产过程以及作为药物的用途。
• Metalloenzyme inhibitor compounds
  申请人：Selenity Therapeutics (Bermuda), Ltd.

  公开号：US10357493B2

  公开（公告）日：2019-07-23

  Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

  本文提供了具有 HDAC6 调节活性的化合物，以及治疗由 HDAC6 介导的疾病、失调或症状的方法。
• Piperdine CXCR7 receptor modulators
  申请人：IDORSIA PHARMACEUTICALS LTD

  公开号：US10752620B2

  公开（公告）日：2020-08-25

  The present invention relates to piperidine derivatives of formula (I) wherein Ar1, Ar2, RAr1, R1, R2 and R3 are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

  本发明涉及式 (I) 的哌啶衍生物 其中 Ar1、Ar2、RAr1、R1、R2 和 R3 如描述中所述，它们的制备，它们的药学上可接受的盐，以及它们作为药物的用途，含有一种或多种式 (I) 化合物的药物组合物，特别是它们作为 CXCR7 受体调节剂的用途。