trichloro(chloromethyl)germane | 21572-18-9

• 分子结构分类: 有机化合物 - 有机金属化合物 - 金属烷基卤化物
• 英文名称: trichloro(chloromethyl)germane
• 英文别名: Trichlor-chlormethyl-german；Trichlor-chlormethylgerman
• CAS: 21572-18-9
• 化学式: CH₂Cl₄Ge
• 分子量: 228.429
• InChiKey: FBOVPRFEJVXTQW-UHFFFAOYSA-N

物化性质

• 沸点：
  152.91°C (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.42
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  trichloro(chloromethyl)germane 以69%的产率得到
  参考文献：
  名称：

  Terunuma Daiyo, Masuo Koujiro, Kizaki Hiroaki, Nohira Hiroyuki, Bull. Chem. Soc. Jap, 67 (1994) N 1, S 160-164

  摘要：

  DOI：
• 作为产物：
  描述：

  二氯甲烷 生成 trichloro(chloromethyl)germane
  参考文献：
  名称：

  MOCHIDA, KUNIO;TASHIRO, KUMIKO;YOSHIDA, YASUHIRO;MIZUNO, YASUHISA, BULL. CHEM. SOC. JAP., 61,(1988) N 4, 1247-1249

  摘要：

  DOI：

文献信息

• The Germanium–Carbon Bond Cleavage Reaction of (Germylmethyl)amine Derivatives. Mechanism and Stereochemistry
  作者：Daiyo Terunuma、Koujiro Masuo、Hiroaki Kizaki、Hiroyuki Nohira

  DOI：10.1246/bcsj.67.160

  日期：1994.1

  A facile cleavage reaction of the germanium–carbon bond of (germylmethyl)amine derivatives to give a germyl anion and an azomethine derivative was developed. The effects of substituents such as phenyl, benzyl, and ethyl groups on the germanium and nitrogen atoms of the (germylmethyl)amine derivatives on the cleavage reaction, were investigated. The mechanism was also investigated based on the stereochemistry

  开发了（锗基甲基）胺衍生物的锗-碳键的简便裂解反应，生成锗基阴离子和偶氮甲碱衍生物。研究了苯基、苄基和乙基等取代基对（锗基甲基）胺衍生物的锗和氮原子对裂解反应的影响。还基于使用光学活性有机锗化合物的裂解反应的立体化学研究了该机制。
• Syntheses and pharmacological characterization of achiral and chiral enantiopure C/Si/Ge-analogous derivatives of the muscarinic antagonist cycrimine: a study on C/Si/Ge bioisosterism
  作者：Reinhold Tacke、Thomas Kornek、Tilman Heinrich、Christian Burschka、Martin Penka、Melanie Pülm、Christine Keim、Ernst Mutschler、Günter Lambrecht

  DOI：10.1016/s0022-328x(01)01179-2

  日期：2001.12

  The C/Si/Ge-analogous compounds rac-Ph(c-C5H9)El(CH2OH)CH2CH2NR2 (NR2=piperidino; El=C, rac-3a; El=Si, rac-3b; El=Ge, rac-3c) and (c-C5H9)2El(CH2OH)CH2CH2NR2 (NR2=piperidino; El=C, 5a; El=Si, 5b; El=Ge, 5c) were prepared in multi-step syntheses. The (R)- and (S)-enantiomers of 3a–c were obtained by resolution of the respective racemates using the antipodes of O,O′-dibenzoyltartaric acid (resolution

  C / Si / Ge类似化合物rac -Ph（c -C 5 H 9）El（CH 2 OH）CH 2 CH 2 NR 2（NR 2 = piperidino; El = C，rac - 3a ; El = Si，rac - 3b ; El = Ge，rac - 3c）和（c -C 5 H 9）2 El（CH 2 OH）CH 2 CH 2 NR 2（NR 2 = piperidino; El = C，5a ; El = Si，5b ; 通过多步合成制备E1 ＝ Ge，5c）。的（[R ）-和（小号的） -对映体3A - Ç通过使用的对映体的相应外消旋体拆分获得ø，ö '-dibenzoyltartaric酸（分辨率为外消旋-图3a，）Ô，ø -二- ' p -甲苯基酒石酸（rac - 3b的拆分）或1,1'-联萘-2,2'-二基磷酸氢盐（rac - 3c的拆分）。（R）-的对映体纯度3a -
• Chemistry of Germanium Atoms. II. Reactions of Thermally Evaporated Germanium Vapor with Organic Halides
  作者：Kunio Mochida、Kumiko Tashiro、Yasuhiro Yoshida、Yasuhisa Mizuno

  DOI：10.1246/bcsj.61.1247

  日期：1988.4

  Thermally generated germanium atoms were found to react with organic halides by insertion into carbon–halogen bonds. The resulting germylenes abstracted halogens from organic halides to form trihalogermyl derivatives. Tetrahalogermanes were also formed by the abstraction of halogens with germanium atoms.

  发现热产生的锗原子通过插入碳 - 卤素键与有机卤化物反应。所得锗烯从有机卤化物中提取卤素以形成三卤锗基衍生物。四卤锗也是通过用锗原子提取卤素而形成的。
• Preparation of New Optically Active Germylmethylamine Derivatives
  作者：Daiyo Terunuma、Hiroaki Kizaki、Takashi Sato、Koujiro Masuo、Hiroyuki Nohira

  DOI：10.1246/bcsj.66.664

  日期：1993.2

  New optically active organogermanium compounds, such as [methylphenyl(o-tolyl)-, benzylmethylphenyl-, benzylmethyl(o-tolyl)-, and benzyl(o-methoxyphenyl)methylgermyl]methylamine, were prepared in high optical purity.

  以高光学纯度制备了新的光学活性有机锗化合物，如[甲基苯基(邻甲苯基)-、苄基甲基苯基-、苄基甲基(邻甲苯基)-和苄基(邻甲氧基苯基)甲基锗基]甲胺。
• The Reaction of Germanium Atoms with Organic Halides
  作者：Kunio Mochida、Kumiko Tashiro

  DOI：10.1246/cl.1987.1105

  日期：1987.6.5

  Co-condensation of thermally evaporated germanium vapor with organic halides yields a mixture of trihalogermyl derivatives and tetrahalogermanes as major products. The nature of these reactions is discussed.

  热蒸发的锗蒸气与有机卤化物的共缩合产生作为主要产物的三卤锗衍生物和四卤锗烷的混合物。讨论了这些反应的性质。